Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model
Summary Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C 14 ) have not yet been reported. In this study an evaluation of the ability of C 14...
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| Veröffentlicht in: | Investigational new drugs 2012-06, Vol.30 (3), p.870-879 |
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| creator | Locatelli, Claudriana Carvalho, Deborah Regina Mascarello, Alessandra de Cordova, Clarissa Amorin Silva Yunes, Rosendo Augusto Nunes, Ricardo Jose Pilati, Celso Creczynski-Pasa, Tânia Beatriz |
| description | Summary
Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C
14
) have not yet been reported. In this study an evaluation of the ability of C
14
to inhibit metastasis, using lung metastases as a model, was carried out. The experimental mouse melanoma model was established by intravenous injection of metastatic B16F10 melanoma cells. The systemic toxicity of C
14
was evaluated in vivo by monitoring the weight, survival, biochemical and hematological parameters, and through histological analysis. It was observed that C
14
decreased lung metastasis in vivo by 80% and increased the survival rate of the animals without toxic effects. Additionally, C
14
induced cytotoxic effects on B16F10 cells, inhibited the inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression, and significantly decreased cell adhesion. These results reveal that C
14
has potent antimetastatic ability and is a good candidate for further study as a potential therapeutic agent for tumor metastases. |
| doi_str_mv | 10.1007/s10637-010-9628-7 |
| format | Article |
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Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C
14
) have not yet been reported. In this study an evaluation of the ability of C
14
to inhibit metastasis, using lung metastases as a model, was carried out. The experimental mouse melanoma model was established by intravenous injection of metastatic B16F10 melanoma cells. The systemic toxicity of C
14
was evaluated in vivo by monitoring the weight, survival, biochemical and hematological parameters, and through histological analysis. It was observed that C
14
decreased lung metastasis in vivo by 80% and increased the survival rate of the animals without toxic effects. Additionally, C
14
induced cytotoxic effects on B16F10 cells, inhibited the inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression, and significantly decreased cell adhesion. These results reveal that C
14
has potent antimetastatic ability and is a good candidate for further study as a potential therapeutic agent for tumor metastases.</description><identifier>ISSN: 0167-6997</identifier><identifier>EISSN: 1573-0646</identifier><identifier>DOI: 10.1007/s10637-010-9628-7</identifier><identifier>PMID: 21221709</identifier><identifier>CODEN: INNDDK</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acids ; Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Apoptosis ; Cancer ; Carbon ; Cell adhesion & migration ; Cell Adhesion - drug effects ; Cell culture ; Cell Survival - drug effects ; Drug therapy ; Drugs ; Female ; Gallic Acid - analogs & derivatives ; Gallic Acid - pharmacology ; Gallic Acid - therapeutic use ; Intercellular Adhesion Molecule-1 - metabolism ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lung Neoplasms - secondary ; Medicine ; Medicine & Public Health ; Melanoma ; Melanoma, Experimental - drug therapy ; Melanoma, Experimental - metabolism ; Melanoma, Experimental - pathology ; Metastasis ; Mice ; Oncology ; Pharmacology ; Pharmacology/Toxicology ; Preclinical Studies ; Skin cancer ; Studies ; Toxicity ; Vascular Cell Adhesion Molecule-1 - metabolism</subject><ispartof>Investigational new drugs, 2012-06, Vol.30 (3), p.870-879</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-6c516b1af4af6380709f1ca8d92b2f37a9b330510ddc4ac3d680178c373e04173</citedby><cites>FETCH-LOGICAL-c471t-6c516b1af4af6380709f1ca8d92b2f37a9b330510ddc4ac3d680178c373e04173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10637-010-9628-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10637-010-9628-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21221709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Locatelli, Claudriana</creatorcontrib><creatorcontrib>Carvalho, Deborah Regina</creatorcontrib><creatorcontrib>Mascarello, Alessandra</creatorcontrib><creatorcontrib>de Cordova, Clarissa Amorin Silva</creatorcontrib><creatorcontrib>Yunes, Rosendo Augusto</creatorcontrib><creatorcontrib>Nunes, Ricardo Jose</creatorcontrib><creatorcontrib>Pilati, Celso</creatorcontrib><creatorcontrib>Creczynski-Pasa, Tânia Beatriz</creatorcontrib><title>Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model</title><title>Investigational new drugs</title><addtitle>Invest New Drugs</addtitle><addtitle>Invest New Drugs</addtitle><description>Summary
Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C
14
) have not yet been reported. In this study an evaluation of the ability of C
14
to inhibit metastasis, using lung metastases as a model, was carried out. The experimental mouse melanoma model was established by intravenous injection of metastatic B16F10 melanoma cells. The systemic toxicity of C
14
was evaluated in vivo by monitoring the weight, survival, biochemical and hematological parameters, and through histological analysis. It was observed that C
14
decreased lung metastasis in vivo by 80% and increased the survival rate of the animals without toxic effects. Additionally, C
14
induced cytotoxic effects on B16F10 cells, inhibited the inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression, and significantly decreased cell adhesion. These results reveal that C
14
has potent antimetastatic ability and is a good candidate for further study as a potential therapeutic agent for tumor metastases.</description><subject>Acids</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Carbon</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell culture</subject><subject>Cell Survival - drug effects</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Female</subject><subject>Gallic Acid - analogs & derivatives</subject><subject>Gallic Acid - pharmacology</subject><subject>Gallic Acid - therapeutic use</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - secondary</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Melanoma, Experimental - pathology</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Oncology</subject><subject>Pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Preclinical Studies</subject><subject>Skin cancer</subject><subject>Studies</subject><subject>Toxicity</subject><subject>Vascular Cell Adhesion Molecule-1 - metabolism</subject><issn>0167-6997</issn><issn>1573-0646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFr3DAQhUVoSLZpfkAuRdBLLm5mLFuyjiEkaSHQS3sWs7IcFCR7I2nT7r-vlk1DKfQyOrxPbx7zGLtA-IwA6iojSKEaQGi0bIdGHbEV9ko0IDv5jq0ApWqk1uqUvc_5CQCEVt0JO22xbVGBXrF4PRcfXaFcqHjLyRb_4suO0zzysPzkeZeLi1Upyy9v98oy8eJKotHZXeCPFAIVx_3MiW-Ss8HP3lLg0QWal0g8Ltvs6hxd-MCOJwrZnb--Z-zH3e33my_Nw7f7rzfXD43tFJZG2h7lGmnqaJJigJp0QkvDqNt1OwlFei0E9AjjaDuyYpQDoBqsUMJBh0qcscuD7yYtz1uXi4k-W1eTzq6mMdhpOWgl-qGin_5Bn5Ztmms6g4gtCtFjVyk8UDYtOSc3mU3ykdLOIJh9F-bQhaldmH0XZh_i46vzdh3d-Pbjz_Er0B6AXKX50aW_Vv_X9TfStpTO</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Locatelli, Claudriana</creator><creator>Carvalho, Deborah Regina</creator><creator>Mascarello, Alessandra</creator><creator>de Cordova, Clarissa Amorin Silva</creator><creator>Yunes, Rosendo Augusto</creator><creator>Nunes, Ricardo Jose</creator><creator>Pilati, Celso</creator><creator>Creczynski-Pasa, Tânia Beatriz</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>K60</scope><scope>K6~</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20120601</creationdate><title>Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model</title><author>Locatelli, Claudriana ; Carvalho, Deborah Regina ; Mascarello, Alessandra ; de Cordova, Clarissa Amorin Silva ; Yunes, Rosendo Augusto ; Nunes, Ricardo Jose ; Pilati, Celso ; Creczynski-Pasa, Tânia Beatriz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-6c516b1af4af6380709f1ca8d92b2f37a9b330510ddc4ac3d680178c373e04173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Carbon</topic><topic>Cell adhesion & migration</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell culture</topic><topic>Cell Survival - drug effects</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>Female</topic><topic>Gallic Acid - analogs & derivatives</topic><topic>Gallic Acid - pharmacology</topic><topic>Gallic Acid - therapeutic use</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - secondary</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Melanoma, Experimental - pathology</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Oncology</topic><topic>Pharmacology</topic><topic>Pharmacology/Toxicology</topic><topic>Preclinical Studies</topic><topic>Skin cancer</topic><topic>Studies</topic><topic>Toxicity</topic><topic>Vascular Cell Adhesion Molecule-1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Locatelli, Claudriana</creatorcontrib><creatorcontrib>Carvalho, Deborah Regina</creatorcontrib><creatorcontrib>Mascarello, Alessandra</creatorcontrib><creatorcontrib>de Cordova, Clarissa Amorin Silva</creatorcontrib><creatorcontrib>Yunes, Rosendo Augusto</creatorcontrib><creatorcontrib>Nunes, Ricardo Jose</creatorcontrib><creatorcontrib>Pilati, Celso</creatorcontrib><creatorcontrib>Creczynski-Pasa, Tânia Beatriz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Investigational new drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Locatelli, Claudriana</au><au>Carvalho, Deborah Regina</au><au>Mascarello, Alessandra</au><au>de Cordova, Clarissa Amorin Silva</au><au>Yunes, Rosendo Augusto</au><au>Nunes, Ricardo Jose</au><au>Pilati, Celso</au><au>Creczynski-Pasa, Tânia Beatriz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model</atitle><jtitle>Investigational new drugs</jtitle><stitle>Invest New Drugs</stitle><addtitle>Invest New Drugs</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>30</volume><issue>3</issue><spage>870</spage><epage>879</epage><pages>870-879</pages><issn>0167-6997</issn><eissn>1573-0646</eissn><coden>INNDDK</coden><abstract>Summary
Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C
14
) have not yet been reported. In this study an evaluation of the ability of C
14
to inhibit metastasis, using lung metastases as a model, was carried out. The experimental mouse melanoma model was established by intravenous injection of metastatic B16F10 melanoma cells. The systemic toxicity of C
14
was evaluated in vivo by monitoring the weight, survival, biochemical and hematological parameters, and through histological analysis. It was observed that C
14
decreased lung metastasis in vivo by 80% and increased the survival rate of the animals without toxic effects. Additionally, C
14
induced cytotoxic effects on B16F10 cells, inhibited the inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression, and significantly decreased cell adhesion. These results reveal that C
14
has potent antimetastatic ability and is a good candidate for further study as a potential therapeutic agent for tumor metastases.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21221709</pmid><doi>10.1007/s10637-010-9628-7</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0167-6997 |
| ispartof | Investigational new drugs, 2012-06, Vol.30 (3), p.870-879 |
| issn | 0167-6997 1573-0646 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acids Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Cancer Carbon Cell adhesion & migration Cell Adhesion - drug effects Cell culture Cell Survival - drug effects Drug therapy Drugs Female Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Gallic Acid - therapeutic use Intercellular Adhesion Molecule-1 - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Medicine Medicine & Public Health Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Metastasis Mice Oncology Pharmacology Pharmacology/Toxicology Preclinical Studies Skin cancer Studies Toxicity Vascular Cell Adhesion Molecule-1 - metabolism |
| title | Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model |
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