How to optimize current treatment of genotype 2 hepatitis C virus infection

The standard of care (SOC) for hepatitis C virus (HCV) genotype 2 is pegylated interferon (PEG‐IFN) plus ribavirin (RBV). Even though most patients can be cured with this therapy after 24 weeks, tailoring treatment can improve its safety and efficacy in special populations. Thus, shortening treatmen...

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Veröffentlicht in:Liver international 2014-02, Vol.34 (s1), p.13-17
Hauptverfasser: Marciano, Sebastián, Gadano, Adrián C.
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Gadano, Adrián C.
description The standard of care (SOC) for hepatitis C virus (HCV) genotype 2 is pegylated interferon (PEG‐IFN) plus ribavirin (RBV). Even though most patients can be cured with this therapy after 24 weeks, tailoring treatment can improve its safety and efficacy in special populations. Thus, shortening treatment together with a weight‐based RBV dosing approach has been considered satisfactory in patients with positive predictors of response. With the development of the direct antiviral agents (DAAs), shorter, better tolerated and more efficient treatments for HCV genotype 2 will become available, including interferon‐free regimens. Until these new treatments are released, the decision to treat patients with HCV genotype 2 with currently approved drugs or to wait for future options must be made, taking into account the stage of fibrosis.
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subjects Algorithms
Antiviral agents
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
cirrhosis
direct antiviral agents
Drug Therapy, Combination - methods
Drug Therapy, Combination - standards
Genotype
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis C - drug therapy
Hepatitis C virus
Humans
Interferon-alpha - therapeutic use
pegylated interferon
Polyethylene Glycols - therapeutic use
predictors of treatment response
Recombinant Proteins - therapeutic use
ribavirin
Ribavirin - therapeutic use
Standard of Care - trends
Time Factors
treatment duration
Treatment Outcome
title How to optimize current treatment of genotype 2 hepatitis C virus infection
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