Tropisetron suppresses collagen synthesis in skin fibroblasts via [alpha]7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model

Objective There is increasing evidence that serotonin (5-hydroxytryptamine [5-HT]) and distinct 5-HT receptors are involved in the pathogenesis of systemic sclerosis. The aim of this study was to test the hypothesis that tropisetron, a routinely used antiemetic agent previously characterized as a 5-...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-03, Vol.65 (3), p.792-804
Hauptverfasser:	Stegemann, Agatha, Sindrilaru, Anca, Eckes, Beate, del Rey, Adriana, Heinick, Alexander, Schulte, Jan S, Müller, Frank U, Grando, Sergei A, Fiebich, Bernd L, Scharffetter-Kochanek, Karin, Luger, Thomas A, Böhm, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Collagen Scleroderma Wound healing
Online-Zugang:	Volltext
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