Ang II induce kidney damage by recruiting inflammatory cells and up regulates PPAR gamma and Renin 1 gene: effect of β carotene on chronic renal damage

Antioxidants are widely used for prevention of diseases associated with oxidative stress and ischemic disorder. We investigated the hypothesis of antioxidants (α-tocopherol and β-carotene) can suppress the renal disorder in apo E-/-mice. Renal damage induced by chronic infusion of Angiotensin II (An...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2013-10, Vol.36 (3), p.277-285
Hauptverfasser:	Kaliappan, Gopal, Nagarajan, P., Moorthy, Ramya, Kalai Gana Selvi, S., Avinash Raj, T., Mahesh Kumar, Jerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - adverse effects Angiotensin II - genetics Angiotensin II - pharmacology Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism beta Carotene - pharmacology Cardiology Cell Movement - drug effects Female Hematology Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology Kidney Glomerulus - injuries Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidney Tubules, Proximal - injuries Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Male Medicine Medicine & Public Health Mice Mice, Knockout Polycystic Kidney Diseases - chemically induced Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - pathology PPAR gamma - genetics PPAR gamma - metabolism Renal Insufficiency, Chronic - chemically induced Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Renin - genetics Renin - metabolism
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