Low-level laser therapy enhances the expression of osteogenic factors during bone repair in rats
The aim of this study was to evaluate the effects of low-level laser therapy (LLLT) on bone formation, immunoexpression of osteogenic factors, and biomechanical properties in a tibial bone defect model in rats. Sixty male Wistar rats were distributed into bone defect control group (CG) and laser irr...
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| Veröffentlicht in: | Lasers in medical science 2014-01, Vol.29 (1), p.147-156 |
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| creator | Tim, Carla Roberta Pinto, Karina Nogueira Zambone Rossi, Bruno Rafael Orsini Fernandes, Kelly Matsumoto, Mariza Akemi Parizotto, Nivaldo Antonio Rennó, Ana Claudia Muniz |
| description | The aim of this study was to evaluate the effects of low-level laser therapy (LLLT) on bone formation, immunoexpression of osteogenic factors, and biomechanical properties in a tibial bone defect model in rats. Sixty male Wistar rats were distributed into bone defect control group (CG) and laser irradiated group (LG). Animals were euthanized on days 15, 30, and 45 post-injury. The histological and morphometric analysis showed that the treated animals presented no inflammatory infiltrate and a better tissue organization at 15 and 30 days postsurgery. Also, a higher amount of newly formed bone was observed at 15 days postsurgery. No statistically significant difference was observed in cyclooxygenase-2 immunoexpression among the groups at 15, 30, and 45 days in the immunohistochemical analysis. Considering RUNX-2, the immunoexpression was statistically higher in the LG compared to the CG at 45 days. BMP-9 immunoexpression was significantly higher in the LG in comparison to CG at day 30. However, there was no expressivity for this immunomarker, both in the CG and LG, at the day 45 postsurgery. No statistically significant difference was observed in the receptor activator of nuclear factor kappa-B ligand immunoexpression among the groups in all periods evaluated. No statistically significant difference among the groups was observed in the maximal load in any period of time. Our findings indicate that laser therapy improved bone healing by accelerating the development of newly formed bone and activating the osteogenic factors on tibial defects, but the biomechanical properties in LG were not improved. |
| doi_str_mv | 10.1007/s10103-013-1302-9 |
| format | Article |
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Sixty male Wistar rats were distributed into bone defect control group (CG) and laser irradiated group (LG). Animals were euthanized on days 15, 30, and 45 post-injury. The histological and morphometric analysis showed that the treated animals presented no inflammatory infiltrate and a better tissue organization at 15 and 30 days postsurgery. Also, a higher amount of newly formed bone was observed at 15 days postsurgery. No statistically significant difference was observed in cyclooxygenase-2 immunoexpression among the groups at 15, 30, and 45 days in the immunohistochemical analysis. Considering RUNX-2, the immunoexpression was statistically higher in the LG compared to the CG at 45 days. BMP-9 immunoexpression was significantly higher in the LG in comparison to CG at day 30. However, there was no expressivity for this immunomarker, both in the CG and LG, at the day 45 postsurgery. No statistically significant difference was observed in the receptor activator of nuclear factor kappa-B ligand immunoexpression among the groups in all periods evaluated. No statistically significant difference among the groups was observed in the maximal load in any period of time. Our findings indicate that laser therapy improved bone healing by accelerating the development of newly formed bone and activating the osteogenic factors on tibial defects, but the biomechanical properties in LG were not improved.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-013-1302-9</identifier><identifier>PMID: 23515631</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Animals ; Biomechanical Phenomena ; Biomechanics ; Bone Regeneration - physiology ; Bone Regeneration - radiation effects ; Bones ; Clinical outcomes ; Core Binding Factor Alpha 1 Subunit - metabolism ; Cyclooxygenase 2 - metabolism ; Dentistry ; Fracture Healing - physiology ; Fracture Healing - radiation effects ; Growth Differentiation Factor 2 - metabolism ; Immunohistochemistry ; Laser surgery ; Lasers ; Lasers, Semiconductor - therapeutic use ; Low-Level Light Therapy ; Male ; Medicine ; Medicine & Public Health ; Optical Devices ; Optics ; Original Article ; Osteoblasts - metabolism ; Osteoblasts - pathology ; Osteoblasts - radiation effects ; Osteogenesis - physiology ; Osteogenesis - radiation effects ; Photonics ; Quantum Optics ; RANK Ligand - metabolism ; Rats ; Rats, Wistar ; Tibial Fractures - pathology ; Tibial Fractures - physiopathology ; Tibial Fractures - radiotherapy ; Time Factors</subject><ispartof>Lasers in medical science, 2014-01, Vol.29 (1), p.147-156</ispartof><rights>Springer-Verlag London 2013</rights><rights>Springer-Verlag London 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-8acce8eb0f16aa40fac4297ca5adf37072c7dd06043e2e848211b768af1b2103</citedby><cites>FETCH-LOGICAL-c471t-8acce8eb0f16aa40fac4297ca5adf37072c7dd06043e2e848211b768af1b2103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-013-1302-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-013-1302-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23515631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tim, Carla Roberta</creatorcontrib><creatorcontrib>Pinto, Karina Nogueira Zambone</creatorcontrib><creatorcontrib>Rossi, Bruno Rafael Orsini</creatorcontrib><creatorcontrib>Fernandes, Kelly</creatorcontrib><creatorcontrib>Matsumoto, Mariza Akemi</creatorcontrib><creatorcontrib>Parizotto, Nivaldo Antonio</creatorcontrib><creatorcontrib>Rennó, Ana Claudia Muniz</creatorcontrib><title>Low-level laser therapy enhances the expression of osteogenic factors during bone repair in rats</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>The aim of this study was to evaluate the effects of low-level laser therapy (LLLT) on bone formation, immunoexpression of osteogenic factors, and biomechanical properties in a tibial bone defect model in rats. Sixty male Wistar rats were distributed into bone defect control group (CG) and laser irradiated group (LG). Animals were euthanized on days 15, 30, and 45 post-injury. The histological and morphometric analysis showed that the treated animals presented no inflammatory infiltrate and a better tissue organization at 15 and 30 days postsurgery. Also, a higher amount of newly formed bone was observed at 15 days postsurgery. No statistically significant difference was observed in cyclooxygenase-2 immunoexpression among the groups at 15, 30, and 45 days in the immunohistochemical analysis. Considering RUNX-2, the immunoexpression was statistically higher in the LG compared to the CG at 45 days. BMP-9 immunoexpression was significantly higher in the LG in comparison to CG at day 30. However, there was no expressivity for this immunomarker, both in the CG and LG, at the day 45 postsurgery. No statistically significant difference was observed in the receptor activator of nuclear factor kappa-B ligand immunoexpression among the groups in all periods evaluated. No statistically significant difference among the groups was observed in the maximal load in any period of time. Our findings indicate that laser therapy improved bone healing by accelerating the development of newly formed bone and activating the osteogenic factors on tibial defects, but the biomechanical properties in LG were not improved.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Bone Regeneration - physiology</subject><subject>Bone Regeneration - radiation effects</subject><subject>Bones</subject><subject>Clinical outcomes</subject><subject>Core Binding Factor Alpha 1 Subunit - metabolism</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dentistry</subject><subject>Fracture Healing - physiology</subject><subject>Fracture Healing - radiation effects</subject><subject>Growth Differentiation Factor 2 - metabolism</subject><subject>Immunohistochemistry</subject><subject>Laser surgery</subject><subject>Lasers</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Osteoblasts - 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Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tim, Carla Roberta</au><au>Pinto, Karina Nogueira Zambone</au><au>Rossi, Bruno Rafael Orsini</au><au>Fernandes, Kelly</au><au>Matsumoto, Mariza Akemi</au><au>Parizotto, Nivaldo Antonio</au><au>Rennó, Ana Claudia Muniz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-level laser therapy enhances the expression of osteogenic factors during bone repair in rats</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>29</volume><issue>1</issue><spage>147</spage><epage>156</epage><pages>147-156</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>The aim of this study was to evaluate the effects of low-level laser therapy (LLLT) on bone formation, immunoexpression of osteogenic factors, and biomechanical properties in a tibial bone defect model in rats. Sixty male Wistar rats were distributed into bone defect control group (CG) and laser irradiated group (LG). Animals were euthanized on days 15, 30, and 45 post-injury. The histological and morphometric analysis showed that the treated animals presented no inflammatory infiltrate and a better tissue organization at 15 and 30 days postsurgery. Also, a higher amount of newly formed bone was observed at 15 days postsurgery. No statistically significant difference was observed in cyclooxygenase-2 immunoexpression among the groups at 15, 30, and 45 days in the immunohistochemical analysis. Considering RUNX-2, the immunoexpression was statistically higher in the LG compared to the CG at 45 days. BMP-9 immunoexpression was significantly higher in the LG in comparison to CG at day 30. However, there was no expressivity for this immunomarker, both in the CG and LG, at the day 45 postsurgery. No statistically significant difference was observed in the receptor activator of nuclear factor kappa-B ligand immunoexpression among the groups in all periods evaluated. No statistically significant difference among the groups was observed in the maximal load in any period of time. Our findings indicate that laser therapy improved bone healing by accelerating the development of newly formed bone and activating the osteogenic factors on tibial defects, but the biomechanical properties in LG were not improved.</abstract><cop>London</cop><pub>Springer London</pub><pmid>23515631</pmid><doi>10.1007/s10103-013-1302-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biomechanical Phenomena Biomechanics Bone Regeneration - physiology Bone Regeneration - radiation effects Bones Clinical outcomes Core Binding Factor Alpha 1 Subunit - metabolism Cyclooxygenase 2 - metabolism Dentistry Fracture Healing - physiology Fracture Healing - radiation effects Growth Differentiation Factor 2 - metabolism Immunohistochemistry Laser surgery Lasers Lasers, Semiconductor - therapeutic use Low-Level Light Therapy Male Medicine Medicine & Public Health Optical Devices Optics Original Article Osteoblasts - metabolism Osteoblasts - pathology Osteoblasts - radiation effects Osteogenesis - physiology Osteogenesis - radiation effects Photonics Quantum Optics RANK Ligand - metabolism Rats Rats, Wistar Tibial Fractures - pathology Tibial Fractures - physiopathology Tibial Fractures - radiotherapy Time Factors |
| title | Low-level laser therapy enhances the expression of osteogenic factors during bone repair in rats |
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