Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991
Objective The aim of our study was to elucidate the pathophysiology of systemic sclerosis-related osteoporosis and the prevalence of vertebral fragility fracture in postmenopausal women with systemic sclerosis (SSc). Methodology Fifty-four postmenopausal women with scleroderma and 54 postmenopausal...
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| Veröffentlicht in: | PloS one 2013-06, Vol.8 (6) |
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| creator | Atteritano, Marco Sorbara, Stefania Bagnato, Gianluca Miceli, Giovanni Sangari, Donatella Morgante, Salvatore Visalli, Elisa Bagnato, Gianfilippo |
| description | Objective The aim of our study was to elucidate the pathophysiology of systemic sclerosis-related osteoporosis and the prevalence of vertebral fragility fracture in postmenopausal women with systemic sclerosis (SSc). Methodology Fifty-four postmenopausal women with scleroderma and 54 postmenopausal controls matched for age, BMI, and smoking habits were studied. BMD was measured by dual energy-x-ray absorptiometry at spine and femur, and by ultrasonography at calcaneus The markers of bone turnover included serum osteocalcin and urinary deoxypyridinoline. All subjects had a spine X-ray to ascertain the presence of vertebral fractures. Results bone mineral density at lumbar spine (BMD 0.78 plus or minus 0.08 vs 0.88 plus or minus 0.07; p |
| doi_str_mv | 10.1371/journal.pone.0066991 |
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| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1496881797</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1496881797</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_14968817973</originalsourceid><addsrcrecordid>eNqVjs1KAzEURkNBsP68gYu77MKOSWMzE3c6WtwUhOm-hOkV06ZJvTdRBl_eUnwBVwc-Dh9HiBslK6VrdbdNhaIL1SFFrKQ0xlo1EmNl9WxqZlKfiwvmrZRz3RgzFj9PRw-WPiK5AM8Y2efhFk7r6viUvpBg6WiHxODiBhbk-lwIGXyEN5c9xszw7fMHdANn3Pseuj4gJfb8AI_QOkZoU8yUAnS5bIYK8JR1Jc7eXWC8_uOlmCxeVu3r9EDpsyDn9d5zjyG4iKnwWt1b0zSqtrX-h_oLpn1Ypg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1496881797</pqid></control><display><type>article</type><title>Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Atteritano, Marco ; Sorbara, Stefania ; Bagnato, Gianluca ; Miceli, Giovanni ; Sangari, Donatella ; Morgante, Salvatore ; Visalli, Elisa ; Bagnato, Gianfilippo</creator><creatorcontrib>Atteritano, Marco ; Sorbara, Stefania ; Bagnato, Gianluca ; Miceli, Giovanni ; Sangari, Donatella ; Morgante, Salvatore ; Visalli, Elisa ; Bagnato, Gianfilippo</creatorcontrib><description>Objective The aim of our study was to elucidate the pathophysiology of systemic sclerosis-related osteoporosis and the prevalence of vertebral fragility fracture in postmenopausal women with systemic sclerosis (SSc). Methodology Fifty-four postmenopausal women with scleroderma and 54 postmenopausal controls matched for age, BMI, and smoking habits were studied. BMD was measured by dual energy-x-ray absorptiometry at spine and femur, and by ultrasonography at calcaneus The markers of bone turnover included serum osteocalcin and urinary deoxypyridinoline. All subjects had a spine X-ray to ascertain the presence of vertebral fractures. Results bone mineral density at lumbar spine (BMD 0.78 plus or minus 0.08 vs 0.88 plus or minus 0.07; p<0,001), femoral neck (BMD: 0.56 plus or minus 0.04 vs 0.72 plus or minus 0.07; p<0,001) and total femur (BMD: 0.57 plus or minus 0.04 vs 0.71 plus or minus 0.06; p<0,001) and ultrasound parameter at calcaneus (SI: 80.10 plus or minus 5.10 vs 94.80 plus or minus 6.10 p<0,001) were significantly lower in scleroderma compared with controls; bone turnover markers and parathyroid hormone level were significantly higher in scleroderma compared with controls, while serum of 25(OH)D3 was significantly lower. In scleroderma group the serum levels of 25(OH)D3 significantly correlated with PTH levels, BMD, stiffness index and bone turnover markers. One or more moderate or severe vertebral fractures were found in 13 patients with scleroderma, wherease in control group only one patient had a mild vertebral fracture. Conclusion Our data shows, for the first time, that vertebral fractures are frequent in subjects with scleroderma, and suggest that lower levels of 25(OH)D3 may play a role in the risk of osteoporosis and vertebral fractures.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0066991</identifier><language>eng</language><subject>Age</subject><ispartof>PloS one, 2013-06, Vol.8 (6)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Atteritano, Marco</creatorcontrib><creatorcontrib>Sorbara, Stefania</creatorcontrib><creatorcontrib>Bagnato, Gianluca</creatorcontrib><creatorcontrib>Miceli, Giovanni</creatorcontrib><creatorcontrib>Sangari, Donatella</creatorcontrib><creatorcontrib>Morgante, Salvatore</creatorcontrib><creatorcontrib>Visalli, Elisa</creatorcontrib><creatorcontrib>Bagnato, Gianfilippo</creatorcontrib><title>Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991</title><title>PloS one</title><description>Objective The aim of our study was to elucidate the pathophysiology of systemic sclerosis-related osteoporosis and the prevalence of vertebral fragility fracture in postmenopausal women with systemic sclerosis (SSc). Methodology Fifty-four postmenopausal women with scleroderma and 54 postmenopausal controls matched for age, BMI, and smoking habits were studied. BMD was measured by dual energy-x-ray absorptiometry at spine and femur, and by ultrasonography at calcaneus The markers of bone turnover included serum osteocalcin and urinary deoxypyridinoline. All subjects had a spine X-ray to ascertain the presence of vertebral fractures. Results bone mineral density at lumbar spine (BMD 0.78 plus or minus 0.08 vs 0.88 plus or minus 0.07; p<0,001), femoral neck (BMD: 0.56 plus or minus 0.04 vs 0.72 plus or minus 0.07; p<0,001) and total femur (BMD: 0.57 plus or minus 0.04 vs 0.71 plus or minus 0.06; p<0,001) and ultrasound parameter at calcaneus (SI: 80.10 plus or minus 5.10 vs 94.80 plus or minus 6.10 p<0,001) were significantly lower in scleroderma compared with controls; bone turnover markers and parathyroid hormone level were significantly higher in scleroderma compared with controls, while serum of 25(OH)D3 was significantly lower. In scleroderma group the serum levels of 25(OH)D3 significantly correlated with PTH levels, BMD, stiffness index and bone turnover markers. One or more moderate or severe vertebral fractures were found in 13 patients with scleroderma, wherease in control group only one patient had a mild vertebral fracture. Conclusion Our data shows, for the first time, that vertebral fractures are frequent in subjects with scleroderma, and suggest that lower levels of 25(OH)D3 may play a role in the risk of osteoporosis and vertebral fractures.</description><subject>Age</subject><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVjs1KAzEURkNBsP68gYu77MKOSWMzE3c6WtwUhOm-hOkV06ZJvTdRBl_eUnwBVwc-Dh9HiBslK6VrdbdNhaIL1SFFrKQ0xlo1EmNl9WxqZlKfiwvmrZRz3RgzFj9PRw-WPiK5AM8Y2efhFk7r6viUvpBg6WiHxODiBhbk-lwIGXyEN5c9xszw7fMHdANn3Pseuj4gJfb8AI_QOkZoU8yUAnS5bIYK8JR1Jc7eXWC8_uOlmCxeVu3r9EDpsyDn9d5zjyG4iKnwWt1b0zSqtrX-h_oLpn1Ypg</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Atteritano, Marco</creator><creator>Sorbara, Stefania</creator><creator>Bagnato, Gianluca</creator><creator>Miceli, Giovanni</creator><creator>Sangari, Donatella</creator><creator>Morgante, Salvatore</creator><creator>Visalli, Elisa</creator><creator>Bagnato, Gianfilippo</creator><scope>7ST</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20130601</creationdate><title>Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991</title><author>Atteritano, Marco ; Sorbara, Stefania ; Bagnato, Gianluca ; Miceli, Giovanni ; Sangari, Donatella ; Morgante, Salvatore ; Visalli, Elisa ; Bagnato, Gianfilippo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_14968817973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atteritano, Marco</creatorcontrib><creatorcontrib>Sorbara, Stefania</creatorcontrib><creatorcontrib>Bagnato, Gianluca</creatorcontrib><creatorcontrib>Miceli, Giovanni</creatorcontrib><creatorcontrib>Sangari, Donatella</creatorcontrib><creatorcontrib>Morgante, Salvatore</creatorcontrib><creatorcontrib>Visalli, Elisa</creatorcontrib><creatorcontrib>Bagnato, Gianfilippo</creatorcontrib><collection>Environment Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atteritano, Marco</au><au>Sorbara, Stefania</au><au>Bagnato, Gianluca</au><au>Miceli, Giovanni</au><au>Sangari, Donatella</au><au>Morgante, Salvatore</au><au>Visalli, Elisa</au><au>Bagnato, Gianfilippo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991</atitle><jtitle>PloS one</jtitle><date>2013-06-01</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><eissn>1932-6203</eissn><abstract>Objective The aim of our study was to elucidate the pathophysiology of systemic sclerosis-related osteoporosis and the prevalence of vertebral fragility fracture in postmenopausal women with systemic sclerosis (SSc). Methodology Fifty-four postmenopausal women with scleroderma and 54 postmenopausal controls matched for age, BMI, and smoking habits were studied. BMD was measured by dual energy-x-ray absorptiometry at spine and femur, and by ultrasonography at calcaneus The markers of bone turnover included serum osteocalcin and urinary deoxypyridinoline. All subjects had a spine X-ray to ascertain the presence of vertebral fractures. Results bone mineral density at lumbar spine (BMD 0.78 plus or minus 0.08 vs 0.88 plus or minus 0.07; p<0,001), femoral neck (BMD: 0.56 plus or minus 0.04 vs 0.72 plus or minus 0.07; p<0,001) and total femur (BMD: 0.57 plus or minus 0.04 vs 0.71 plus or minus 0.06; p<0,001) and ultrasound parameter at calcaneus (SI: 80.10 plus or minus 5.10 vs 94.80 plus or minus 6.10 p<0,001) were significantly lower in scleroderma compared with controls; bone turnover markers and parathyroid hormone level were significantly higher in scleroderma compared with controls, while serum of 25(OH)D3 was significantly lower. In scleroderma group the serum levels of 25(OH)D3 significantly correlated with PTH levels, BMD, stiffness index and bone turnover markers. One or more moderate or severe vertebral fractures were found in 13 patients with scleroderma, wherease in control group only one patient had a mild vertebral fracture. Conclusion Our data shows, for the first time, that vertebral fractures are frequent in subjects with scleroderma, and suggest that lower levels of 25(OH)D3 may play a role in the risk of osteoporosis and vertebral fractures.</abstract><doi>10.1371/journal.pone.0066991</doi></addata></record> |
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| subjects | Age |
| title | Bone Mineral Density, Bone Turnover Markers and Fractures in Patients with Systemic Sclerosis: A Case Control Study. e66991 |
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