Effect of inhibitors of the host cell RNA polymerase II on African swine fever virus multiplication

The role of the host cell RNA polymerase II in African swine fever (ASF) virus growth has been examined using inhibitors of this enzyme. The adenosine analog 5,6-dichloro-l-β- d-ribofuranosylbenzimidazole (DRB), an inhibitor of mRNA precursor synthesis in mammalian cells, strongly inhibits the produ...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1988-05, Vol.164 (1), p.280-283
Hauptverfasser:	Salas, José, Salas, Maria L., Viñuela, Eladio
Format:	Artikel
Sprache:	eng
Schlagworte:	AFRICAN SWINE FEVER VIRUS African Swine Fever Virus - drug effects African Swine Fever Virus - physiology African Swine Fever Virus - ultrastructure Amanitins - pharmacology Animals Biological and medical sciences Dichlororibofuranosylbenzimidazole - pharmacology ENZYME INHIBITORS Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Iridoviridae - drug effects Macrophages Myeloid cells: ontogeny, maturation, markers, receptors RNA Polymerase II - antagonists & inhibitors Swine TRANSFERASAS TRANSFERASE TRANSFERASES Vero Cells - enzymology Virion - ultrastructure VIRUS DE LA PESTE PORCINA AFRICANA VIRUS PESTE PORCINE AFRICAINE Virus Replication - drug effects
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