Rapid oxidative stress induced by N-nitrosamines

We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarl...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-08, Vol.146 (3), p.1047-1054
Hauptverfasser:	AHOTUPA, M, BUSSACCHINI-GRIOT, V, BEREZIAT, J.-C, CAMUS, A.-M, BARTSCH, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Carcinogens - pharmacology Diethylnitrosamine - analogs & derivatives Diethylnitrosamine - pharmacology Dimethylnitrosamine - analogs & derivatives Dimethylnitrosamine - pharmacology Ethane - metabolism Exact sciences and technology Glutathione - metabolism Kinetics Lipid Peroxides - metabolism Liver - drug effects Liver - metabolism Male Nitrosamines - pharmacology Other techniques and industries Peroxidases - metabolism Rats Rats, Inbred Strains Structure-Activity Relationship Vitamin A - metabolism
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