Rapid oxidative stress induced by N-nitrosamines
We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarl...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1987-08, Vol.146 (3), p.1047-1054 |
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| container_title | Biochemical and biophysical research communications |
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| creator | AHOTUPA, M BUSSACCHINI-GRIOT, V BEREZIAT, J.-C CAMUS, A.-M BARTSCH, H |
| description | We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarly, lipid peroxidation (LP) in the liver (measured by four methods) increased rapidly showing a peak 20 min after NDMA dose. The increase of LP was preceded by a decrease in retinol concentration in the liver. N-Nitrosodiethanolamine, too, increased EE and LP in the liver, whereas N-nitrosomethylbenzylamine had no effect. Thus, hepatocarcinogenic NA induced LP in their target tissue, and the LP enhancing effects of NA were not related to their acute toxic effects. |
| doi_str_mv | 10.1016/0006-291X(87)90753-4 |
| format | Article |
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N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarly, lipid peroxidation (LP) in the liver (measured by four methods) increased rapidly showing a peak 20 min after NDMA dose. The increase of LP was preceded by a decrease in retinol concentration in the liver. N-Nitrosodiethanolamine, too, increased EE and LP in the liver, whereas N-nitrosomethylbenzylamine had no effect. Thus, hepatocarcinogenic NA induced LP in their target tissue, and the LP enhancing effects of NA were not related to their acute toxic effects.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(87)90753-4</identifier><identifier>PMID: 3619914</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Animals ; Applied sciences ; Carcinogens - pharmacology ; Diethylnitrosamine - analogs & derivatives ; Diethylnitrosamine - pharmacology ; Dimethylnitrosamine - analogs & derivatives ; Dimethylnitrosamine - pharmacology ; Ethane - metabolism ; Exact sciences and technology ; Glutathione - metabolism ; Kinetics ; Lipid Peroxides - metabolism ; Liver - drug effects ; Liver - metabolism ; Male ; Nitrosamines - pharmacology ; Other techniques and industries ; Peroxidases - metabolism ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship ; Vitamin A - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1987-08, Vol.146 (3), p.1047-1054</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-24fb5ad57e00ba86118ca06c82e9772dab4a70647fa01f1e35e23f63b70aadc3</citedby><cites>FETCH-LOGICAL-c362t-24fb5ad57e00ba86118ca06c82e9772dab4a70647fa01f1e35e23f63b70aadc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7844938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3619914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AHOTUPA, M</creatorcontrib><creatorcontrib>BUSSACCHINI-GRIOT, V</creatorcontrib><creatorcontrib>BEREZIAT, J.-C</creatorcontrib><creatorcontrib>CAMUS, A.-M</creatorcontrib><creatorcontrib>BARTSCH, H</creatorcontrib><title>Rapid oxidative stress induced by N-nitrosamines</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarly, lipid peroxidation (LP) in the liver (measured by four methods) increased rapidly showing a peak 20 min after NDMA dose. The increase of LP was preceded by a decrease in retinol concentration in the liver. N-Nitrosodiethanolamine, too, increased EE and LP in the liver, whereas N-nitrosomethylbenzylamine had no effect. Thus, hepatocarcinogenic NA induced LP in their target tissue, and the LP enhancing effects of NA were not related to their acute toxic effects.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Carcinogens - pharmacology</subject><subject>Diethylnitrosamine - analogs & derivatives</subject><subject>Diethylnitrosamine - pharmacology</subject><subject>Dimethylnitrosamine - analogs & derivatives</subject><subject>Dimethylnitrosamine - pharmacology</subject><subject>Ethane - metabolism</subject><subject>Exact sciences and technology</subject><subject>Glutathione - metabolism</subject><subject>Kinetics</subject><subject>Lipid Peroxides - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Nitrosamines - pharmacology</subject><subject>Other techniques and industries</subject><subject>Peroxidases - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Structure-Activity Relationship</subject><subject>Vitamin A - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMo4zj6DxS6ENFF9d4mTZqlDL5gUJBZuAu3aQqRPsamFeff29Eyq7s43zlcPsbOEW4RUN4BgIwTjR_XmbrRoFIeiwM2R9AQJwjikM33yDE7CeETAFFIPWMzLlFrFHMG77TxRdT--IJ6_-2i0HcuhMg3xWBdEeXb6DVufN-1gWrfuHDKjkqqgjub7oKtHx_Wy-d49fb0srxfxZbLpI8TUeYpFalyADllEjGzBNJmidNKJQXlghRIoUoCLNHx1CW8lDxXQFRYvmBX_7Obrv0aXOhN7YN1VUWNa4dgUGgpQOIIin_Qji-GzpVm0_mauq1BMDtPZifB7CSYTJk_T0aMtYtpf8hrV-xLk5gxv5xyCpaqsqPG-rDHVCaE5hn_BRrxb3Y</recordid><startdate>19870814</startdate><enddate>19870814</enddate><creator>AHOTUPA, M</creator><creator>BUSSACCHINI-GRIOT, V</creator><creator>BEREZIAT, J.-C</creator><creator>CAMUS, A.-M</creator><creator>BARTSCH, H</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19870814</creationdate><title>Rapid oxidative stress induced by N-nitrosamines</title><author>AHOTUPA, M ; BUSSACCHINI-GRIOT, V ; BEREZIAT, J.-C ; CAMUS, A.-M ; BARTSCH, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-24fb5ad57e00ba86118ca06c82e9772dab4a70647fa01f1e35e23f63b70aadc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Carcinogens - pharmacology</topic><topic>Diethylnitrosamine - analogs & derivatives</topic><topic>Diethylnitrosamine - pharmacology</topic><topic>Dimethylnitrosamine - analogs & derivatives</topic><topic>Dimethylnitrosamine - pharmacology</topic><topic>Ethane - metabolism</topic><topic>Exact sciences and technology</topic><topic>Glutathione - metabolism</topic><topic>Kinetics</topic><topic>Lipid Peroxides - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Nitrosamines - pharmacology</topic><topic>Other techniques and industries</topic><topic>Peroxidases - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Structure-Activity Relationship</topic><topic>Vitamin A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AHOTUPA, M</creatorcontrib><creatorcontrib>BUSSACCHINI-GRIOT, V</creatorcontrib><creatorcontrib>BEREZIAT, J.-C</creatorcontrib><creatorcontrib>CAMUS, A.-M</creatorcontrib><creatorcontrib>BARTSCH, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AHOTUPA, M</au><au>BUSSACCHINI-GRIOT, V</au><au>BEREZIAT, J.-C</au><au>CAMUS, A.-M</au><au>BARTSCH, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid oxidative stress induced by N-nitrosamines</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1987-08-14</date><risdate>1987</risdate><volume>146</volume><issue>3</issue><spage>1047</spage><epage>1054</epage><pages>1047-1054</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarly, lipid peroxidation (LP) in the liver (measured by four methods) increased rapidly showing a peak 20 min after NDMA dose. The increase of LP was preceded by a decrease in retinol concentration in the liver. N-Nitrosodiethanolamine, too, increased EE and LP in the liver, whereas N-nitrosomethylbenzylamine had no effect. Thus, hepatocarcinogenic NA induced LP in their target tissue, and the LP enhancing effects of NA were not related to their acute toxic effects.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>3619914</pmid><doi>10.1016/0006-291X(87)90753-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1987-08, Vol.146 (3), p.1047-1054 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Applied sciences Carcinogens - pharmacology Diethylnitrosamine - analogs & derivatives Diethylnitrosamine - pharmacology Dimethylnitrosamine - analogs & derivatives Dimethylnitrosamine - pharmacology Ethane - metabolism Exact sciences and technology Glutathione - metabolism Kinetics Lipid Peroxides - metabolism Liver - drug effects Liver - metabolism Male Nitrosamines - pharmacology Other techniques and industries Peroxidases - metabolism Rats Rats, Inbred Strains Structure-Activity Relationship Vitamin A - metabolism |
| title | Rapid oxidative stress induced by N-nitrosamines |
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