The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III)
The effect of vitamin E, folic acid, pyridoxine (vitamin B 6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lym...
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| Veröffentlicht in: | Food and chemical toxicology 1988, Vol.26 (3), p.195-203 |
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| creator | Sinkeldam, E.J. de Groot, A.P. van den Berg, H. Chappel, C.I. |
| description | The effect of vitamin E, folic acid, pyridoxine (vitamin B
6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lymphocytes in rats fed AC could be prevented by the addition of pyridoxine to the diet. The activity of AC in reducing the number of circulating lymphocytes also closely resembled that of the pyridoxine antagonist 4′-deoxypyridoxine. After the isolation and identification of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), comparative studies indicated that THI was the component of AC responsible for reducing the number of circulating lymphocytes. Although the effect of AC was reduced or prevented by increasing dietary pyridoxine, the lymphocyte reduction associated with the administration of THI was not materially affected by the dietary level of pyridoxine. |
| doi_str_mv | 10.1016/0278-6915(88)90119-6 |
| format | Article |
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6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lymphocytes in rats fed AC could be prevented by the addition of pyridoxine to the diet. The activity of AC in reducing the number of circulating lymphocytes also closely resembled that of the pyridoxine antagonist 4′-deoxypyridoxine. After the isolation and identification of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), comparative studies indicated that THI was the component of AC responsible for reducing the number of circulating lymphocytes. Although the effect of AC was reduced or prevented by increasing dietary pyridoxine, the lymphocyte reduction associated with the administration of THI was not materially affected by the dietary level of pyridoxine.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/0278-6915(88)90119-6</identifier><identifier>PMID: 3366420</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; blood ; Candy ; caramel ; Carbohydrates ; Diet ; food coloring ; Food Coloring Agents - toxicity ; Food toxicology ; Imidazoles - toxicity ; Leukocyte Count - drug effects ; lymphocytes ; Lymphocytes - drug effects ; Male ; Medical sciences ; Organic Chemicals ; pyridoxine ; Pyridoxine - administration & dosage ; Pyridoxine - analogs & derivatives ; Pyridoxine - pharmacology ; Pyridoxine - toxicity ; Rats ; Rats, Inbred Strains ; Toxicology ; Vitamins - pharmacology</subject><ispartof>Food and chemical toxicology, 1988, Vol.26 (3), p.195-203</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-2af539cbaf3af0c3181ce91f2ca9105e0428773ccec18f897f87c26e4196fecb3</citedby><cites>FETCH-LOGICAL-c441t-2af539cbaf3af0c3181ce91f2ca9105e0428773ccec18f897f87c26e4196fecb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-6915(88)90119-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7061937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3366420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sinkeldam, E.J.</creatorcontrib><creatorcontrib>de Groot, A.P.</creatorcontrib><creatorcontrib>van den Berg, H.</creatorcontrib><creatorcontrib>Chappel, C.I.</creatorcontrib><title>The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III)</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>The effect of vitamin E, folic acid, pyridoxine (vitamin B
6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lymphocytes in rats fed AC could be prevented by the addition of pyridoxine to the diet. The activity of AC in reducing the number of circulating lymphocytes also closely resembled that of the pyridoxine antagonist 4′-deoxypyridoxine. After the isolation and identification of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), comparative studies indicated that THI was the component of AC responsible for reducing the number of circulating lymphocytes. Although the effect of AC was reduced or prevented by increasing dietary pyridoxine, the lymphocyte reduction associated with the administration of THI was not materially affected by the dietary level of pyridoxine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Candy</subject><subject>caramel</subject><subject>Carbohydrates</subject><subject>Diet</subject><subject>food coloring</subject><subject>Food Coloring Agents - toxicity</subject><subject>Food toxicology</subject><subject>Imidazoles - toxicity</subject><subject>Leukocyte Count - drug effects</subject><subject>lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organic Chemicals</subject><subject>pyridoxine</subject><subject>Pyridoxine - administration & dosage</subject><subject>Pyridoxine - analogs & derivatives</subject><subject>Pyridoxine - pharmacology</subject><subject>Pyridoxine - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicology</subject><subject>Vitamins - pharmacology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQQC0EKtvCPwCRA0LtIeCJE39cKqGqwEqVONCeLWcypkZJvNgJYv89SXe1R04-vDej0TNjb4B_BA7yE6-ULqWB5lLrK8MBTCmfsQ1oJUopGnjONiflJTvP-RfnXIGSZ-xMCCnrim8Y3j9SQd4TTkX0xW6fQhf_hpGKOBbTwsZ5aCmtrN8Pu8eI-4lyEQ6w7WPsVpbclAtPXYEuuYH6AmMf51Rcbrfbq1fshXd9ptfH94I9fLm9v_lW3n3_ur35fFdiXcNUVs43wmDrvHCeowANSAZ8hc4Ab4jXlVZKIBKC9toorxVWkmowcrm_FRfsw2HvLsXfM-XJDiEj9b0bKc7ZQm1kxXWziPVBxBRzTuTtLoXBpb0Fbte2dg1n13BWa_vU1spl7O1x_9wO1J2GjjEX_v7IXUbX--RGDPmkKS7BCLVo7w6ad9G6n2lRHn5UHASveGPM06Lrg0FLrT-Bks0YaETqQlo-ynYx_P_Sf7_Enf8</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Sinkeldam, E.J.</creator><creator>de Groot, A.P.</creator><creator>van den Berg, H.</creator><creator>Chappel, C.I.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1988</creationdate><title>The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III)</title><author>Sinkeldam, E.J. ; de Groot, A.P. ; van den Berg, H. ; Chappel, C.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-2af539cbaf3af0c3181ce91f2ca9105e0428773ccec18f897f87c26e4196fecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Candy</topic><topic>caramel</topic><topic>Carbohydrates</topic><topic>Diet</topic><topic>food coloring</topic><topic>Food Coloring Agents - toxicity</topic><topic>Food toxicology</topic><topic>Imidazoles - toxicity</topic><topic>Leukocyte Count - drug effects</topic><topic>lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organic Chemicals</topic><topic>pyridoxine</topic><topic>Pyridoxine - administration & dosage</topic><topic>Pyridoxine - analogs & derivatives</topic><topic>Pyridoxine - pharmacology</topic><topic>Pyridoxine - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicology</topic><topic>Vitamins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sinkeldam, E.J.</creatorcontrib><creatorcontrib>de Groot, A.P.</creatorcontrib><creatorcontrib>van den Berg, H.</creatorcontrib><creatorcontrib>Chappel, C.I.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sinkeldam, E.J.</au><au>de Groot, A.P.</au><au>van den Berg, H.</au><au>Chappel, C.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III)</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1988</date><risdate>1988</risdate><volume>26</volume><issue>3</issue><spage>195</spage><epage>203</epage><pages>195-203</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>The effect of vitamin E, folic acid, pyridoxine (vitamin B
6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lymphocytes in rats fed AC could be prevented by the addition of pyridoxine to the diet. The activity of AC in reducing the number of circulating lymphocytes also closely resembled that of the pyridoxine antagonist 4′-deoxypyridoxine. After the isolation and identification of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), comparative studies indicated that THI was the component of AC responsible for reducing the number of circulating lymphocytes. Although the effect of AC was reduced or prevented by increasing dietary pyridoxine, the lymphocyte reduction associated with the administration of THI was not materially affected by the dietary level of pyridoxine.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3366420</pmid><doi>10.1016/0278-6915(88)90119-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Food and chemical toxicology, 1988, Vol.26 (3), p.195-203 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences blood Candy caramel Carbohydrates Diet food coloring Food Coloring Agents - toxicity Food toxicology Imidazoles - toxicity Leukocyte Count - drug effects lymphocytes Lymphocytes - drug effects Male Medical sciences Organic Chemicals pyridoxine Pyridoxine - administration & dosage Pyridoxine - analogs & derivatives Pyridoxine - pharmacology Pyridoxine - toxicity Rats Rats, Inbred Strains Toxicology Vitamins - pharmacology |
| title | The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III) |
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