Acquired chromosome rearrangements in human lymphocytes: effect of aging
A prospective study of structural rearrangements occurring in normal lymphocytes was carried out. For each of two newborns and four young and two old adults, about 1000 metaphases from 72-h and 120 from 48-h cultures were studied. The frequency of rearrangements between bands 7p14, 7q35, 14q11.2 or...
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| Veröffentlicht in: | Human genetics 1988-06, Vol.79 (2), p.147-150 |
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| creator | PRIEUR, M AL ACHKAR, W LEFRANCOIS, D LOMBARD, M MULERIS, M RICOUL, M SABATIER, L VIEGAS-PEQUIGNOT, E AURIAS, A COUTURIER, J DUTRILLAUX, A. M DUTRILLAUX, B FLURY-HERARD, A GERBAULT-SEUREAU, M HOFFSCHIR, F LAMOLIATTE, E |
| description | A prospective study of structural rearrangements occurring in normal lymphocytes was carried out. For each of two newborns and four young and two old adults, about 1000 metaphases from 72-h and 120 from 48-h cultures were studied. The frequency of rearrangements between bands 7p14, 7q35, 14q11.2 or 14q12 and 14qter, which is on the average about 0.003, is higher in newborns (0.0043) than in adults (0.0024). Conversely, the rearrangements involving other bands, which have a frequency of 0.025 on the average, are more frequent in old adults (f = 0.038) than in young adults (f = 0.025) and newborns (f = 0.013). The first type of rearrangement, which occurs in utero, may correspond to immunoglobulin and related gene rearrangements. The other rearrangements seem to accumulate progressively and may reflect exposure to mutagens. It is import to discriminate these two types of rearrangements when studying the effect of low doses of mutagens. |
| doi_str_mv | 10.1007/BF00280554 |
| format | Article |
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Conversely, the rearrangements involving other bands, which have a frequency of 0.025 on the average, are more frequent in old adults (f = 0.038) than in young adults (f = 0.025) and newborns (f = 0.013). The first type of rearrangement, which occurs in utero, may correspond to immunoglobulin and related gene rearrangements. The other rearrangements seem to accumulate progressively and may reflect exposure to mutagens. It is import to discriminate these two types of rearrangements when studying the effect of low doses of mutagens.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/BF00280554</identifier><identifier>PMID: 3164704</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Aging - genetics ; Biological and medical sciences ; Chromosome Aberrations ; Cytogenetics ; Female ; Fundamental and applied biological sciences. 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Conversely, the rearrangements involving other bands, which have a frequency of 0.025 on the average, are more frequent in old adults (f = 0.038) than in young adults (f = 0.025) and newborns (f = 0.013). The first type of rearrangement, which occurs in utero, may correspond to immunoglobulin and related gene rearrangements. The other rearrangements seem to accumulate progressively and may reflect exposure to mutagens. It is import to discriminate these two types of rearrangements when studying the effect of low doses of mutagens.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - genetics</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. 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| ispartof | Human genetics, 1988-06, Vol.79 (2), p.147-150 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aging - genetics Biological and medical sciences Chromosome Aberrations Cytogenetics Female Fundamental and applied biological sciences. Psychology Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans Infant, Newborn Lymphocytes - ultrastructure Male Prospective Studies |
| title | Acquired chromosome rearrangements in human lymphocytes: effect of aging |
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