Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor

Tumor necrosis factor (TNF) is a 17,000-Da protein which is produced by mononuclear cells upon exposure to endotoxin. Increases in adherence, phagocytosis, hydrogen peroxide release, and lysozyme secretion have been demonstrated after prolonged incubation of human neutrophils with TNF. In this study...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-12, Vol.139 (11), p.3783-3791
Hauptverfasser:	Berkow, RL, Wang, D, Larrick, JW, Dodson, RW, Howard, TH
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell Aggregation - drug effects Drug Synergism Exocytosis - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Miscellaneous N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - metabolism Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors Superoxides - biosynthesis Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - pharmacology
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