Syntheses of indolo[1,2- a ]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation

Syntheses of indolo[1,2- a ]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation

The synthesis of indolo[1,2- a ]quinazolinone starting from 2-iodobenzamide and indole derivatives is reported. In this two-step procedure, indole is N -arylated with 2-iodobenzamide derivatives via Ullman coupling, followed by an intramolecular C–H amidation using a palladium catalyst.

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (5), p.2274-2283
Hauptverfasser: Kotipalli, Trimurtulu, Kavala, Veerababurao, Janreddy, Donala, Kuo, Chun-Wei, Kuo, Ting-Shen, Huang, Hsiu-Ni, He, Chiu-Hui, Yao, Ching-Fa
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Sprache:eng
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Zusammenfassung:The synthesis of indolo[1,2- a ]quinazolinone starting from 2-iodobenzamide and indole derivatives is reported. In this two-step procedure, indole is N -arylated with 2-iodobenzamide derivatives via Ullman coupling, followed by an intramolecular C–H amidation using a palladium catalyst.
ISSN:2046-2069
2046-2069
DOI:10.1039/C3RA44798G