Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery
Paclitaxel (Tax) is an anticancer drug with extremely low water solubility, and development of the formulation without organic solvents is highly desirable. Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibi...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2013-12, Vol.15 (12), p.1-11, Article 2098 |
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| creator | Kojima, Chie Watanabe, Kenji Nagayasu, Takashi Nishio, Yuki Makiura, Rie Nakahira, Atsushi |
| description | Paclitaxel (Tax) is an anticancer drug with extremely low water solubility, and development of the formulation without organic solvents is highly desirable. Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibility in water limits its application. In this study, HA-decorated poly(lactide-co-glycolide) (PLG) spheres with several micrometers were prepared and characterized. PLG microspheres adsorbed Tax, independent in the HA decorating, and their water dispersibility was retained after the HA decorating. Tax-loaded HA-decorated PLG microspheres (Tax/HA/PLG) could thus be highly dispersed in water, increasing their cellular uptake. Most Tax molecules were stably adsorbed to the HA and HA-decorated PLG (HA/PLG) particles. Although the cytotoxicity of Tax-loaded HA was much lower than that of free Tax, the drug activity of Tax/HA/PLG was markedly improved. Since the morphology of microtubules was changed after the Tax/HA/PLG treatment, the HA/PLG could work as a carrier for Tax. |
| doi_str_mv | 10.1007/s11051-013-2098-z |
| format | Article |
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Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibility in water limits its application. In this study, HA-decorated poly(lactide-co-glycolide) (PLG) spheres with several micrometers were prepared and characterized. PLG microspheres adsorbed Tax, independent in the HA decorating, and their water dispersibility was retained after the HA decorating. Tax-loaded HA-decorated PLG microspheres (Tax/HA/PLG) could thus be highly dispersed in water, increasing their cellular uptake. Most Tax molecules were stably adsorbed to the HA and HA-decorated PLG (HA/PLG) particles. Although the cytotoxicity of Tax-loaded HA was much lower than that of free Tax, the drug activity of Tax/HA/PLG was markedly improved. Since the morphology of microtubules was changed after the Tax/HA/PLG treatment, the HA/PLG could work as a carrier for Tax.</description><identifier>ISSN: 1388-0764</identifier><identifier>EISSN: 1572-896X</identifier><identifier>DOI: 10.1007/s11051-013-2098-z</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biological and medical sciences ; Biotechnology ; Cellular ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Condensed matter: structure, mechanical and thermal properties ; Cytotoxicity ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Inorganic Chemistry ; Lasers ; Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties ; Materials Science ; Methods. Procedures. Technologies ; Nanoparticles ; Nanotechnology ; Optical Devices ; Optics ; Organic solvents ; Others ; Photonics ; Physical Chemistry ; Physics ; Research Paper ; Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties) ; Various methods and equipments</subject><ispartof>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2013-12, Vol.15 (12), p.1-11, Article 2098</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><rights>2015 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-a0b4b35aeaf80057f313c82b59c41a2650cf5a9574eade42f01280d2ab467c9e3</citedby><cites>FETCH-LOGICAL-c379t-a0b4b35aeaf80057f313c82b59c41a2650cf5a9574eade42f01280d2ab467c9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11051-013-2098-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11051-013-2098-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28037124$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, Chie</creatorcontrib><creatorcontrib>Watanabe, Kenji</creatorcontrib><creatorcontrib>Nagayasu, Takashi</creatorcontrib><creatorcontrib>Nishio, Yuki</creatorcontrib><creatorcontrib>Makiura, Rie</creatorcontrib><creatorcontrib>Nakahira, Atsushi</creatorcontrib><title>Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>Paclitaxel (Tax) is an anticancer drug with extremely low water solubility, and development of the formulation without organic solvents is highly desirable. Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibility in water limits its application. In this study, HA-decorated poly(lactide-co-glycolide) (PLG) spheres with several micrometers were prepared and characterized. PLG microspheres adsorbed Tax, independent in the HA decorating, and their water dispersibility was retained after the HA decorating. Tax-loaded HA-decorated PLG microspheres (Tax/HA/PLG) could thus be highly dispersed in water, increasing their cellular uptake. Most Tax molecules were stably adsorbed to the HA and HA-decorated PLG (HA/PLG) particles. Although the cytotoxicity of Tax-loaded HA was much lower than that of free Tax, the drug activity of Tax/HA/PLG was markedly improved. Since the morphology of microtubules was changed after the Tax/HA/PLG treatment, the HA/PLG could work as a carrier for Tax.</description><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cellular</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Condensed matter: structure, mechanical and thermal properties</subject><subject>Cytotoxicity</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inorganic Chemistry</subject><subject>Lasers</subject><subject>Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties</subject><subject>Materials Science</subject><subject>Methods. Procedures. 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One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kojima, Chie</au><au>Watanabe, Kenji</au><au>Nagayasu, Takashi</au><au>Nishio, Yuki</au><au>Makiura, Rie</au><au>Nakahira, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery</atitle><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle><stitle>J Nanopart Res</stitle><date>2013-12-01</date><risdate>2013</risdate><volume>15</volume><issue>12</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><artnum>2098</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>Paclitaxel (Tax) is an anticancer drug with extremely low water solubility, and development of the formulation without organic solvents is highly desirable. Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibility in water limits its application. In this study, HA-decorated poly(lactide-co-glycolide) (PLG) spheres with several micrometers were prepared and characterized. PLG microspheres adsorbed Tax, independent in the HA decorating, and their water dispersibility was retained after the HA decorating. Tax-loaded HA-decorated PLG microspheres (Tax/HA/PLG) could thus be highly dispersed in water, increasing their cellular uptake. Most Tax molecules were stably adsorbed to the HA and HA-decorated PLG (HA/PLG) particles. Although the cytotoxicity of Tax-loaded HA was much lower than that of free Tax, the drug activity of Tax/HA/PLG was markedly improved. Since the morphology of microtubules was changed after the Tax/HA/PLG treatment, the HA/PLG could work as a carrier for Tax.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-013-2098-z</doi><tpages>11</tpages></addata></record> |
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| subjects | Biological and medical sciences Biotechnology Cellular Characterization and Evaluation of Materials Chemistry and Materials Science Condensed matter: structure, mechanical and thermal properties Cytotoxicity Exact sciences and technology Fundamental and applied biological sciences. Psychology Inorganic Chemistry Lasers Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties Materials Science Methods. Procedures. Technologies Nanoparticles Nanotechnology Optical Devices Optics Organic solvents Others Photonics Physical Chemistry Physics Research Paper Surfaces and interfaces thin films and whiskers (structure and nonelectronic properties) Various methods and equipments |
| title | Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery |
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