Iron-Catalyzed Efficient Synthesis of Amides from Aldehydes and Amine Hydrochloride Salts

Iron-Catalyzed Efficient Synthesis of Amides from Aldehydes and Amine Hydrochloride Salts

A practical and efficient method for the synthesis of amides has been developed by iron‐catalysed oxidative amidation of aldehydes with amine hydrochloride salts. A wide range of amides have been obtained in good to excellent yields under mild conditions. The application of this novel amide formatio...

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Veröffentlicht in:Advanced synthesis & catalysis 2012-05, Vol.354 (8), p.1407-1412
Hauptverfasser: Ghosh, Subhash Chandra, Ngiam, Joyce S. Y., Chai, Christina L. L., Seayad, Abdul M., Dang, Tuan Thanh, Chen, Anqi
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Aliphatic compounds
amidation
amides
amine salts
catalysis
Chemistry
Exact sciences and technology
iron(II) sulphate
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:A practical and efficient method for the synthesis of amides has been developed by iron‐catalysed oxidative amidation of aldehydes with amine hydrochloride salts. A wide range of amides have been obtained in good to excellent yields under mild conditions. The application of this novel amide formation reaction to the synthesis of pharmaceutical compounds has been successfully demonstrated.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200020