Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging

RATIONALE Although Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging (MSI) is uniquely suited for whole‐body (WB) tissue distribution study of drugs, success in this area has been difficult. Here, we present WB tissue distribution studies using DESI‐MSI and a new histological tissu...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2014-01, Vol.28 (2), p.185-190
Hauptverfasser:	Liu, Jingzhou, Gingras, Jacinthe, Ganley, Kenneth P., Vismeh, Ramin, Teffera, Yohannes, Zhao, Zhiyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antipsychotic Agents - pharmacokinetics Clozapine - pharmacokinetics Desorption Female Mice Spectrometry, Mass, Electrospray Ionization - methods Tissue Distribution Whole Body Imaging - methods
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