Benzo[a]pyrene increases DNA double strand break repair in vitro and in vivo: A possible mechanism for benzo[a]pyrene-induced toxicity

•Examination of BaP-induced DNA double strand breaks and repair activation was investigated.•BaP-induced increased homologous recombinational DNA repair in CHO 3–6 cells.•BaP-induced increased positive staining for recombination events in the lung and thymus of exposed pKZ1 animals.•BaP decreased ge...

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Veröffentlicht in:	Mutation research. Genetic toxicology and environmental mutagenesis 2014-01, Vol.760, p.64-69
Hauptverfasser:	Tung, Emily W.Y., Philbrook, Nicola A., Belanger, Christine L., Ansari, Saad, Winn, Louise M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - genetics Ataxia Telangiectasia Mutated Proteins - genetics Benzo(a)pyrene - toxicity Benzo[a]pyrene beta-Galactosidase - genetics beta-Galactosidase - metabolism Blotting, Western CHO Cells Cricetinae Cricetulus Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded - drug effects DNA double strand break DNA Repair DNA-Binding Proteins - genetics Gene expression Gene Expression - drug effects Homologous recombination Homologous Recombination - drug effects Kidney - drug effects Kidney - metabolism Ku Autoantigen Liver - drug effects Liver - metabolism Lung - drug effects Lung - metabolism Male Mice Mice, Transgenic Mutation Nonhomologous end-joining Polycyclic aromatic hydrocarbons Reactive oxygen species Reverse Transcriptase Polymerase Chain Reaction Rodents Signal Transduction - drug effects Spleen - drug effects Spleen - metabolism Thymus Gland - drug effects Thymus Gland - metabolism Toxicity Tumor Suppressor Protein p53 - genetics γH2AX
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