Glucocorticoids regulate barrier function and claudin expression in intestinal epithelial cells via MKP-1

Barrier dysfunction is pivotal to the pathogenesis of inflammatory bowel diseases (IBD) and collagenous colitis. Glucocorticoids restore barrier function in Crohn's disease, but whether this reflects attenuated inflammation or an epithelial-specific action has not yet been addressed. Using filt...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2014-02, Vol.306 (3), p.G218-G228
Hauptverfasser:	Fischer, Andreas, Gluth, Markus, Weege, Friderike, Pape, Ulrich-Frank, Wiedenmann, Bertram, Baumgart, Daniel C, Theuring, Franz
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Caco-2 Cells - drug effects Caco-2 Cells - metabolism Cells Cells, Cultured Claudins - metabolism Dexamethasone - pharmacology Digestive system Dual Specificity Phosphatase 1 - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Glucocorticoids - genetics Glucocorticoids - metabolism Glucocorticoids - pharmacology Humans Inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Occludin - metabolism Pathogenesis Protein expression Steroids Tight Junctions - drug effects Tight Junctions - metabolism Tumor Necrosis Factor-alpha - metabolism
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