Redirection of doublecortin-positive cell migration by over-expression of the chemokines MCP-1, MIP-1α and GRO-α in the adult rat brain

Highlights • Ectopic MCP-1, MIP-1α and GRO-α redirect Dcx+ cell migration after 4 weeks of expression. • Ectopic MCP-1 and MIP-1α, but not GRO-α redirect Dcx+ cells after 8 weeks of expression. • GRO-α is less effective in inducing Dcx+ cell migration when compared to MCP-1.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-02, Vol.260, p.240-248
Hauptverfasser:	Tang, S.K, Knobloch, R.A, Maucksch, C, Connor, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Movement - physiology chemokine Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokine CCL3 - genetics Chemokine CCL3 - metabolism Chemokine CXCL1 - genetics Chemokine CXCL1 - metabolism Chemokines - genetics Chemokines - metabolism Corpus Striatum - metabolism doublecortin Fundamental and applied biological sciences. Psychology GRO-α Male MCP-1 Microtubule-Associated Proteins - analysis migration MIP-1α Neural Stem Cells - chemistry Neural Stem Cells - physiology Neurology Neuropeptides - analysis Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Ectopic MCP-1, MIP-1α and GRO-α redirect Dcx+ cell migration after 4 weeks of expression. • Ectopic MCP-1 and MIP-1α, but not GRO-α redirect Dcx+ cells after 8 weeks of expression. • GRO-α is less effective in inducing Dcx+ cell migration when compared to MCP-1.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.022