Raman mapping for kinetic analysis of crystallization of amorphous drug based on distributional images

The feasibility of Raman mapping for understanding the crystallization mechanism of an amorphous drug was investigated using described images. The crystallization tendency of amorphous indomethacin under dry condition at 30°C was kinetically evaluated by means of Raman mapping and X-ray powder diffr...

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Veröffentlicht in:	International journal of pharmaceutics 2014-02, Vol.462 (1-2), p.115-122
Hauptverfasser:	Ueda, Hiroshi, Ida, Yasuo, Kadota, Kazunori, Tozuka, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous drug Calorimetry, Differential Scanning Crystallization Crystallization mechanism Feasibility Studies Indomethacin - chemistry Kinetic analysis Kinetics Particle Size Raman mapping Spectrum Analysis, Raman - methods X-Ray Diffraction - methods
Online-Zugang:	Volltext
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