Oesophageal hyperkeratosis: clinicopathological associations
Aims Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well‐studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown. Methods and results W...
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| Veröffentlicht in: | Histopathology 2013-10, Vol.63 (4), p.463-473 |
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| creator | Taggart, Melissa W Rashid, Asif Ross, William A Abraham, Susan C |
| description | Aims
Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well‐studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.
Methods and results
We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (>3 foci in 51% versus 16%, P = 0.0001), involved mid‐oesophagus (51% versus 2%, P |
| doi_str_mv | 10.1111/his.12195 |
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Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well‐studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.
Methods and results
We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (>3 foci in 51% versus 16%, P = 0.0001), involved mid‐oesophagus (51% versus 2%, P < 0.0001), showed endoscopic leucoplakia (24% versus 3%, P = 0.003) and involved current/former alcohol users (51% versus 19%, P = 0.0012). Importantly, invasive squamous carcinoma and squamous dysplasia were seen only in group 2 (47% and 19% versus 0%, P < 0.0001). Further, 42% of group 2, but none of group 1, had benign or malignant squamous lesions of the oral cavity/larynx (P < 0.0001).
Conclusion
Hyperkeratosis involves ~2% of oesophageal biopsies and can be divided into cases occurring within BO/adenocarcinoma and those occurring outside BO/adenocarcinoma. The former lack clinical significance, whereas the latter are associated frequently with oesophageal squamous neoplasia and squamous pathology of the head and neck region.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.12195</identifier><identifier>PMID: 23879628</identifier><identifier>CODEN: HISTDD</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Barrett Esophagus - complications ; Esophageal Diseases - complications ; Esophageal Diseases - epidemiology ; Esophageal Diseases - pathology ; Esophageal Neoplasms - complications ; Female ; Humans ; hyperkeratosis ; Keratosis - complications ; Keratosis - epidemiology ; Keratosis - pathology ; leucoplakia ; Male ; Middle Aged ; oesophagus ; parakeratosis ; Prevalence ; Retrospective Studies ; squamous carcinoma ; squamous dysplasia</subject><ispartof>Histopathology, 2013-10, Vol.63 (4), p.463-473</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-3de8516eec9ee2e6668af68ea11120a1d12d4c08eae407bb12775ab79d39b1443</citedby><cites>FETCH-LOGICAL-c4575-3de8516eec9ee2e6668af68ea11120a1d12d4c08eae407bb12775ab79d39b1443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.12195$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.12195$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23879628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taggart, Melissa W</creatorcontrib><creatorcontrib>Rashid, Asif</creatorcontrib><creatorcontrib>Ross, William A</creatorcontrib><creatorcontrib>Abraham, Susan C</creatorcontrib><title>Oesophageal hyperkeratosis: clinicopathological associations</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well‐studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.
Methods and results
We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (>3 foci in 51% versus 16%, P = 0.0001), involved mid‐oesophagus (51% versus 2%, P < 0.0001), showed endoscopic leucoplakia (24% versus 3%, P = 0.003) and involved current/former alcohol users (51% versus 19%, P = 0.0012). Importantly, invasive squamous carcinoma and squamous dysplasia were seen only in group 2 (47% and 19% versus 0%, P < 0.0001). Further, 42% of group 2, but none of group 1, had benign or malignant squamous lesions of the oral cavity/larynx (P < 0.0001).
Conclusion
Hyperkeratosis involves ~2% of oesophageal biopsies and can be divided into cases occurring within BO/adenocarcinoma and those occurring outside BO/adenocarcinoma. The former lack clinical significance, whereas the latter are associated frequently with oesophageal squamous neoplasia and squamous pathology of the head and neck region.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Barrett Esophagus - complications</subject><subject>Esophageal Diseases - complications</subject><subject>Esophageal Diseases - epidemiology</subject><subject>Esophageal Diseases - pathology</subject><subject>Esophageal Neoplasms - complications</subject><subject>Female</subject><subject>Humans</subject><subject>hyperkeratosis</subject><subject>Keratosis - complications</subject><subject>Keratosis - epidemiology</subject><subject>Keratosis - pathology</subject><subject>leucoplakia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>oesophagus</subject><subject>parakeratosis</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>squamous carcinoma</subject><subject>squamous dysplasia</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFLHDEUB_AgLXW1PfgFROilPYybl0ySiXgpUncXRaHbIngJmcxbNzq7GZNZ7H77xu7qQTCXQPi9Py9_Qg6AHkM-w7lPx8BAix0yAC5FwYTQH8iAcqoLClLtkr2U7ikFxRn7RHYZr5SWrBqQ02tMoZvbO7Tt0XzdYXzAaPuQfDo5cq1fehc6289DG-68y8amFJy3vQ_L9Jl8nNk24ZftvU_-nP_8fTYuLq9Hk7Mfl4UrhRIFb7ASIBGdRmQopazsTFZo8-6MWmiANaWj-QFLquoamFLC1ko3XNdQlnyffNvkdjE8rjD1ZuGTw7a1SwyrZKDUvMr_hGf69Q29D6u4zNtlxRUDqUWV1feNcjGkFHFmuugXNq4NUPNcqcmVmv-VZnu4TVzVC2xe5UuHGQw34Mm3uH4_yYwn05fIYjPhU49_XydsfDBScSXMzdXITKH8Jc9vhbng_wDBMo62</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Taggart, Melissa W</creator><creator>Rashid, Asif</creator><creator>Ross, William A</creator><creator>Abraham, Susan C</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Oesophageal hyperkeratosis: clinicopathological associations</title><author>Taggart, Melissa W ; Rashid, Asif ; Ross, William A ; Abraham, Susan C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4575-3de8516eec9ee2e6668af68ea11120a1d12d4c08eae407bb12775ab79d39b1443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Barrett Esophagus - complications</topic><topic>Esophageal Diseases - complications</topic><topic>Esophageal Diseases - epidemiology</topic><topic>Esophageal Diseases - pathology</topic><topic>Esophageal Neoplasms - complications</topic><topic>Female</topic><topic>Humans</topic><topic>hyperkeratosis</topic><topic>Keratosis - complications</topic><topic>Keratosis - epidemiology</topic><topic>Keratosis - pathology</topic><topic>leucoplakia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>oesophagus</topic><topic>parakeratosis</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>squamous carcinoma</topic><topic>squamous dysplasia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taggart, Melissa W</creatorcontrib><creatorcontrib>Rashid, Asif</creatorcontrib><creatorcontrib>Ross, William A</creatorcontrib><creatorcontrib>Abraham, Susan C</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taggart, Melissa W</au><au>Rashid, Asif</au><au>Ross, William A</au><au>Abraham, Susan C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oesophageal hyperkeratosis: clinicopathological associations</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2013-10</date><risdate>2013</risdate><volume>63</volume><issue>4</issue><spage>463</spage><epage>473</epage><pages>463-473</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><coden>HISTDD</coden><abstract>Aims
Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well‐studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.
Methods and results
We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (>3 foci in 51% versus 16%, P = 0.0001), involved mid‐oesophagus (51% versus 2%, P < 0.0001), showed endoscopic leucoplakia (24% versus 3%, P = 0.003) and involved current/former alcohol users (51% versus 19%, P = 0.0012). Importantly, invasive squamous carcinoma and squamous dysplasia were seen only in group 2 (47% and 19% versus 0%, P < 0.0001). Further, 42% of group 2, but none of group 1, had benign or malignant squamous lesions of the oral cavity/larynx (P < 0.0001).
Conclusion
Hyperkeratosis involves ~2% of oesophageal biopsies and can be divided into cases occurring within BO/adenocarcinoma and those occurring outside BO/adenocarcinoma. The former lack clinical significance, whereas the latter are associated frequently with oesophageal squamous neoplasia and squamous pathology of the head and neck region.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23879628</pmid><doi>10.1111/his.12195</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Barrett Esophagus - complications Esophageal Diseases - complications Esophageal Diseases - epidemiology Esophageal Diseases - pathology Esophageal Neoplasms - complications Female Humans hyperkeratosis Keratosis - complications Keratosis - epidemiology Keratosis - pathology leucoplakia Male Middle Aged oesophagus parakeratosis Prevalence Retrospective Studies squamous carcinoma squamous dysplasia |
| title | Oesophageal hyperkeratosis: clinicopathological associations |
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