inhibitory activities of the edible green alga Capsosiphon fulvescens on rat lens aldose reductase and advanced glycation end products formation
PURPOSE: Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS: AR inhibitory...
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| Veröffentlicht in: | European journal of nutrition 2014-02, Vol.53 (1), p.233-242 |
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| creator | Islam, Md. Nurul Choi, Sung Hwa Moon, Hye Eun Park, Jin Ju Jung, Hyun Ah Woo, Mi Hee Woo, Hee Chul Choi, Jae Sue |
| description | PURPOSE: Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS: AR inhibitory activities of the selected seaweed species were evaluated using the rat lens aldose reductase (RLAR) inhibitory assay. RESULTS: All extracts exhibited RLAR inhibitory activity, which ranged from 5.87 to 92.71 % at a concentration of 50 μg/mL. Since Capsosiphon fulvescens exhibited significant inhibitory potential and is a frequently used foodstuff, it was selected for a detailed investigation using RLAR and advanced glycation end products (AGE) formation inhibitory assays. Among the different solvent-soluble fractions, the CH₂Cl₂, EtOAc, and n-BuOH fractions showed promising RLAR and AGE formation inhibitory activities. Considering the AR inhibitory potential, CH₂Cl₂ and EtOAc fractions were selected for chromatographic separation and yielded 11 compounds in which capsofulvesin A, capsofulvesin B, and chalinasterol showed potential RLAR inhibitory activity with the respective IC₅₀ values of 52.53, 101.92, and 345.27 μM. Kinetic studies revealed that capsofulvesin A and chalinasterol exhibited mixed type inhibition, while capsofulvesin B exhibited noncompetitive inhibition. To our knowledge, this is the first report of AR inhibitory activity of the glycolipids capsofulvesin A and capsofulvesin B. CONCLUSIONS: Our results clearly indicate the potential RLAR and AGE formation inhibitory activities of C. fulvescens as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of diabetes and related complications. |
| doi_str_mv | 10.1007/s00394-013-0521-y |
| format | Article |
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Nurul ; Choi, Sung Hwa ; Moon, Hye Eun ; Park, Jin Ju ; Jung, Hyun Ah ; Woo, Mi Hee ; Woo, Hee Chul ; Choi, Jae Sue</creator><creatorcontrib>Islam, Md. Nurul ; Choi, Sung Hwa ; Moon, Hye Eun ; Park, Jin Ju ; Jung, Hyun Ah ; Woo, Mi Hee ; Woo, Hee Chul ; Choi, Jae Sue</creatorcontrib><description>PURPOSE: Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS: AR inhibitory activities of the selected seaweed species were evaluated using the rat lens aldose reductase (RLAR) inhibitory assay. RESULTS: All extracts exhibited RLAR inhibitory activity, which ranged from 5.87 to 92.71 % at a concentration of 50 μg/mL. Since Capsosiphon fulvescens exhibited significant inhibitory potential and is a frequently used foodstuff, it was selected for a detailed investigation using RLAR and advanced glycation end products (AGE) formation inhibitory assays. Among the different solvent-soluble fractions, the CH₂Cl₂, EtOAc, and n-BuOH fractions showed promising RLAR and AGE formation inhibitory activities. Considering the AR inhibitory potential, CH₂Cl₂ and EtOAc fractions were selected for chromatographic separation and yielded 11 compounds in which capsofulvesin A, capsofulvesin B, and chalinasterol showed potential RLAR inhibitory activity with the respective IC₅₀ values of 52.53, 101.92, and 345.27 μM. Kinetic studies revealed that capsofulvesin A and chalinasterol exhibited mixed type inhibition, while capsofulvesin B exhibited noncompetitive inhibition. To our knowledge, this is the first report of AR inhibitory activity of the glycolipids capsofulvesin A and capsofulvesin B. CONCLUSIONS: Our results clearly indicate the potential RLAR and AGE formation inhibitory activities of C. fulvescens as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of diabetes and related complications.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-013-0521-y</identifier><identifier>PMID: 23575770</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>aldehyde reductase ; Aldehyde Reductase - antagonists & inhibitors ; Aldehyde Reductase - metabolism ; Animals ; Biological and medical sciences ; Capsosiphon ; Chemistry ; Chemistry and Materials Science ; Chlorophyta - chemistry ; chromatography ; diabetes mellitus ; Diabetes Mellitus - prevention & control ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzyme Inhibitors - pharmacology ; ethanol ; ethyl acetate ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye and associated structures. Visual pathways and centers. Vision ; Feeding. Feeding behavior ; foods ; Fundamental and applied biological sciences. Psychology ; glycation ; Glycation End Products, Advanced - antagonists & inhibitors ; Glycation End Products, Advanced - metabolism ; glycolipids ; inhibitory concentration 50 ; Lens, Crystalline - drug effects ; Lens, Crystalline - enzymology ; macroalgae ; Medical sciences ; Nutrition ; Original Contribution ; Plant Extracts - pharmacology ; Rats ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: nervous system and sense organs</subject><ispartof>European journal of nutrition, 2014-02, Vol.53 (1), p.233-242</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-b52626af5d743a1cf59926af153f0e0653381174c89affa2b759f3f349683b483</citedby><cites>FETCH-LOGICAL-c426t-b52626af5d743a1cf59926af153f0e0653381174c89affa2b759f3f349683b483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-013-0521-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-013-0521-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28270733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23575770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Islam, Md. Nurul</creatorcontrib><creatorcontrib>Choi, Sung Hwa</creatorcontrib><creatorcontrib>Moon, Hye Eun</creatorcontrib><creatorcontrib>Park, Jin Ju</creatorcontrib><creatorcontrib>Jung, Hyun Ah</creatorcontrib><creatorcontrib>Woo, Mi Hee</creatorcontrib><creatorcontrib>Woo, Hee Chul</creatorcontrib><creatorcontrib>Choi, Jae Sue</creatorcontrib><title>inhibitory activities of the edible green alga Capsosiphon fulvescens on rat lens aldose reductase and advanced glycation end products formation</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>PURPOSE: Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS: AR inhibitory activities of the selected seaweed species were evaluated using the rat lens aldose reductase (RLAR) inhibitory assay. RESULTS: All extracts exhibited RLAR inhibitory activity, which ranged from 5.87 to 92.71 % at a concentration of 50 μg/mL. Since Capsosiphon fulvescens exhibited significant inhibitory potential and is a frequently used foodstuff, it was selected for a detailed investigation using RLAR and advanced glycation end products (AGE) formation inhibitory assays. Among the different solvent-soluble fractions, the CH₂Cl₂, EtOAc, and n-BuOH fractions showed promising RLAR and AGE formation inhibitory activities. Considering the AR inhibitory potential, CH₂Cl₂ and EtOAc fractions were selected for chromatographic separation and yielded 11 compounds in which capsofulvesin A, capsofulvesin B, and chalinasterol showed potential RLAR inhibitory activity with the respective IC₅₀ values of 52.53, 101.92, and 345.27 μM. Kinetic studies revealed that capsofulvesin A and chalinasterol exhibited mixed type inhibition, while capsofulvesin B exhibited noncompetitive inhibition. To our knowledge, this is the first report of AR inhibitory activity of the glycolipids capsofulvesin A and capsofulvesin B. CONCLUSIONS: Our results clearly indicate the potential RLAR and AGE formation inhibitory activities of C. fulvescens as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of diabetes and related complications.</description><subject>aldehyde reductase</subject><subject>Aldehyde Reductase - antagonists & inhibitors</subject><subject>Aldehyde Reductase - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capsosiphon</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chlorophyta - chemistry</subject><subject>chromatography</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>ethanol</subject><subject>ethyl acetate</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Feeding. Feeding behavior</subject><subject>foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycation</subject><subject>Glycation End Products, Advanced - antagonists & inhibitors</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>glycolipids</subject><subject>inhibitory concentration 50</subject><subject>Lens, Crystalline - drug effects</subject><subject>Lens, Crystalline - enzymology</subject><subject>macroalgae</subject><subject>Medical sciences</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kU1v1DAQhiMEou3CD-ACllAlLgF_xsmxWvElVeIAPVsTx9515bUXO1kp_4KfjEOWgjhwsDweP-94PG9VvSD4LcFYvssYs47XmLAaC0rq-VF1SThr6oYS8fghxvKiusr5HmNMWUOeVheUCSmkxJfVDxf2rndjTDMCPbqTG53JKFo07g0yg-u9QbtkTEDgd4C2cMwxu-M-BmQnfzJZm1D4gBKMyC8x-CFmg5IZJj1CiSAMCIYTBG0GtPOzhtEVgSnpY4oLlZGN6fAr_ax6YsFn8_y8b6q7D--_bT_Vt18-ft7e3Naa02ase0Eb2oAVg-QMiLai65YzEcxigxvBWEuI5LrtwFqgvRSdZZbxrmlZz1u2qd6sdUsL3yeTR3Vw5S_eQzBxyorwjrVlyLIr6Ot_0Ps4pVC6WyjactGUwW4qslI6xZyTseqY3AHSrAhWi11qtUsVu9Ril5qL5uW58tQfzPCg-O1PAa7PAGQN3qYyRJf_cC2VWDJWOLpyuVyFnUl_tfif11-tIgtRwS6VwndfKSYclyVa1rGfOa24DA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Islam, Md. Nurul</creator><creator>Choi, Sung Hwa</creator><creator>Moon, Hye Eun</creator><creator>Park, Jin Ju</creator><creator>Jung, Hyun Ah</creator><creator>Woo, Mi Hee</creator><creator>Woo, Hee Chul</creator><creator>Choi, Jae Sue</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>inhibitory activities of the edible green alga Capsosiphon fulvescens on rat lens aldose reductase and advanced glycation end products formation</title><author>Islam, Md. Nurul ; Choi, Sung Hwa ; Moon, Hye Eun ; Park, Jin Ju ; Jung, Hyun Ah ; Woo, Mi Hee ; Woo, Hee Chul ; Choi, Jae Sue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-b52626af5d743a1cf59926af153f0e0653381174c89affa2b759f3f349683b483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>aldehyde reductase</topic><topic>Aldehyde Reductase - antagonists & inhibitors</topic><topic>Aldehyde Reductase - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capsosiphon</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chlorophyta - chemistry</topic><topic>chromatography</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>ethanol</topic><topic>ethyl acetate</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Feeding. Feeding behavior</topic><topic>foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glycation</topic><topic>Glycation End Products, Advanced - antagonists & inhibitors</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>glycolipids</topic><topic>inhibitory concentration 50</topic><topic>Lens, Crystalline - drug effects</topic><topic>Lens, Crystalline - enzymology</topic><topic>macroalgae</topic><topic>Medical sciences</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Islam, Md. Nurul</creatorcontrib><creatorcontrib>Choi, Sung Hwa</creatorcontrib><creatorcontrib>Moon, Hye Eun</creatorcontrib><creatorcontrib>Park, Jin Ju</creatorcontrib><creatorcontrib>Jung, Hyun Ah</creatorcontrib><creatorcontrib>Woo, Mi Hee</creatorcontrib><creatorcontrib>Woo, Hee Chul</creatorcontrib><creatorcontrib>Choi, Jae Sue</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Islam, Md. Nurul</au><au>Choi, Sung Hwa</au><au>Moon, Hye Eun</au><au>Park, Jin Ju</au><au>Jung, Hyun Ah</au><au>Woo, Mi Hee</au><au>Woo, Hee Chul</au><au>Choi, Jae Sue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>inhibitory activities of the edible green alga Capsosiphon fulvescens on rat lens aldose reductase and advanced glycation end products formation</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>53</volume><issue>1</issue><spage>233</spage><epage>242</epage><pages>233-242</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>PURPOSE: Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS: AR inhibitory activities of the selected seaweed species were evaluated using the rat lens aldose reductase (RLAR) inhibitory assay. RESULTS: All extracts exhibited RLAR inhibitory activity, which ranged from 5.87 to 92.71 % at a concentration of 50 μg/mL. Since Capsosiphon fulvescens exhibited significant inhibitory potential and is a frequently used foodstuff, it was selected for a detailed investigation using RLAR and advanced glycation end products (AGE) formation inhibitory assays. Among the different solvent-soluble fractions, the CH₂Cl₂, EtOAc, and n-BuOH fractions showed promising RLAR and AGE formation inhibitory activities. Considering the AR inhibitory potential, CH₂Cl₂ and EtOAc fractions were selected for chromatographic separation and yielded 11 compounds in which capsofulvesin A, capsofulvesin B, and chalinasterol showed potential RLAR inhibitory activity with the respective IC₅₀ values of 52.53, 101.92, and 345.27 μM. Kinetic studies revealed that capsofulvesin A and chalinasterol exhibited mixed type inhibition, while capsofulvesin B exhibited noncompetitive inhibition. To our knowledge, this is the first report of AR inhibitory activity of the glycolipids capsofulvesin A and capsofulvesin B. CONCLUSIONS: Our results clearly indicate the potential RLAR and AGE formation inhibitory activities of C. fulvescens as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of diabetes and related complications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23575770</pmid><doi>10.1007/s00394-013-0521-y</doi><tpages>10</tpages></addata></record> |
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| subjects | aldehyde reductase Aldehyde Reductase - antagonists & inhibitors Aldehyde Reductase - metabolism Animals Biological and medical sciences Capsosiphon Chemistry Chemistry and Materials Science Chlorophyta - chemistry chromatography diabetes mellitus Diabetes Mellitus - prevention & control Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - pharmacology ethanol ethyl acetate Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye and associated structures. Visual pathways and centers. Vision Feeding. Feeding behavior foods Fundamental and applied biological sciences. Psychology glycation Glycation End Products, Advanced - antagonists & inhibitors Glycation End Products, Advanced - metabolism glycolipids inhibitory concentration 50 Lens, Crystalline - drug effects Lens, Crystalline - enzymology macroalgae Medical sciences Nutrition Original Contribution Plant Extracts - pharmacology Rats Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: nervous system and sense organs |
| title | inhibitory activities of the edible green alga Capsosiphon fulvescens on rat lens aldose reductase and advanced glycation end products formation |
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