Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging
Aim To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). Materials and methods Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-app...
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| Veröffentlicht in: | Clinical radiology 2014-03, Vol.69 (3), p.294-298 |
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| creator | Li, G Zhou, X Xu, P Pan, X Chen, Y |
| description | Aim To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). Materials and methods Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (λ1), second eigenvalue (λ2), and third eigenvalue (λ3) of the thalamus were measured and the differences were compared. Results The FA values of the thalamus were different in the three groups (group 1: 0.36 ± 0.02; group 2: 0.38 ± 0.02; group 3: 0.43 ± 0.02; F = 54.51, p |
| doi_str_mv | 10.1016/j.crad.2013.10.016 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1493799089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0009926013005060</els_id><sourcerecordid>1493799089</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-6c9e53ea1771f9e266820cadfbbceadd759663ec0feb9989e39cde83b424c6413</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtaqi7lL4AxyQb-WSxR9ZbyyhSlVFAamIA6D2gGQ59mTrJbEXT1Kp_x5H23Lg0INlz_N7TzNvCHnD2Yozrt7vVi5bvxKMywKsCnREllyqdSWEvj0mS8aYrrRQbEFeIu7mshb1CVmIWkrBVbMkv74GlxOOeXLjlIFaREAcII40dXS8g3Jsb4cJaYj0JvSY4hlSHxAsAp0wxG2puq68UqQjREyZhsFuy8cr8qKzPcLrx_uU_Lz6-OPyc3X97dOXy4vrytWcj5VyGtYSLN9seKdBKNUI5qzv2taB9X6z1kpJcKyDVutGg9TOQyPbMoxTNZen5N3Bd5_TnwlwNENAB31vI6QJDa-13GjNGl2o4kCdp8YMndnn0m1-MJyZOVWzM3OqZk51xgpURG8f_ad2AP9P8hRjIXw4EKBMeR8gG3QBogMfMrjR-BSe9z__T-76EIOz_W94ANylKceSn-EGhWHm-7zIea1cMrZmism_3nmfTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1493799089</pqid></control><display><type>article</type><title>Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Li, G ; Zhou, X ; Xu, P ; Pan, X ; Chen, Y</creator><creatorcontrib>Li, G ; Zhou, X ; Xu, P ; Pan, X ; Chen, Y</creatorcontrib><description>Aim To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). Materials and methods Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (λ1), second eigenvalue (λ2), and third eigenvalue (λ3) of the thalamus were measured and the differences were compared. Results The FA values of the thalamus were different in the three groups (group 1: 0.36 ± 0.02; group 2: 0.38 ± 0.02; group 3: 0.43 ± 0.02; F = 54.51, p < 0.001). A statistically significant difference was observed between group 1 and group 2 ( p = 0.003), group 1 and group 3 ( p = 0.001), and group 2 and group 3 ( p < 0.001). The λ1, λ2, and λ3 values of the thalamus were different in the three groups (1.11 ± 0.06 mm2 /s, 1.11 ± 0.06 mm2 /s, and 1.10 ± 0.04 mm2 /s of λ1 in group 1, group 2, and group 3, respectively; 0.82 ± 0.08 mm2 /s, 0.78 ± 0.05 mm2 /s, and 0.72 ± 0.02 mm2 /s of λ2 in group 1, group 2, and group 3, respectively; 0.52 ± 0.05 mm2 /s, 0.49 ± 0.06 mm2 /s, and 0.42 ± 0.06 mm2 /s of λ3 in group 1, group 2, and group 3, respectively; F = 1.65, p = 0.203 of λ1; F = 10.55, p < 0.001 of λ2; F = 4.21, p = 0.021 of λ3; respectively). A statistically significant difference in the λ2 value was observed between group 1 and group 3 ( p < 0.001) and group 2 and group 3 ( p = 0.005). A statistically significant difference in the λ3 value was also observed between group 1 and group 3 ( p = 0.007). No significant difference in the λ1 value was noted between each of the two groups. Conclusions Damage of the thalamus in Wilson's disease patients can be detected using DTI. DTI may provide information regarding thalamus damage in patients with Wilson's disease before abnormal signals on conventional MRI.</description><identifier>ISSN: 0009-9260</identifier><identifier>EISSN: 1365-229X</identifier><identifier>DOI: 10.1016/j.crad.2013.10.016</identifier><identifier>PMID: 24332168</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Anisotropy ; Case-Control Studies ; Child ; Diffusion Tensor Imaging ; Female ; Hepatolenticular Degeneration - pathology ; Humans ; Male ; Radiology ; Retrospective Studies ; Thalamus - pathology</subject><ispartof>Clinical radiology, 2014-03, Vol.69 (3), p.294-298</ispartof><rights>The Royal College of Radiologists</rights><rights>2013 The Royal College of Radiologists</rights><rights>Copyright © 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-6c9e53ea1771f9e266820cadfbbceadd759663ec0feb9989e39cde83b424c6413</citedby><cites>FETCH-LOGICAL-c411t-6c9e53ea1771f9e266820cadfbbceadd759663ec0feb9989e39cde83b424c6413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009926013005060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24332168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, G</creatorcontrib><creatorcontrib>Zhou, X</creatorcontrib><creatorcontrib>Xu, P</creatorcontrib><creatorcontrib>Pan, X</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><title>Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging</title><title>Clinical radiology</title><addtitle>Clin Radiol</addtitle><description>Aim To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). Materials and methods Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (λ1), second eigenvalue (λ2), and third eigenvalue (λ3) of the thalamus were measured and the differences were compared. Results The FA values of the thalamus were different in the three groups (group 1: 0.36 ± 0.02; group 2: 0.38 ± 0.02; group 3: 0.43 ± 0.02; F = 54.51, p < 0.001). A statistically significant difference was observed between group 1 and group 2 ( p = 0.003), group 1 and group 3 ( p = 0.001), and group 2 and group 3 ( p < 0.001). The λ1, λ2, and λ3 values of the thalamus were different in the three groups (1.11 ± 0.06 mm2 /s, 1.11 ± 0.06 mm2 /s, and 1.10 ± 0.04 mm2 /s of λ1 in group 1, group 2, and group 3, respectively; 0.82 ± 0.08 mm2 /s, 0.78 ± 0.05 mm2 /s, and 0.72 ± 0.02 mm2 /s of λ2 in group 1, group 2, and group 3, respectively; 0.52 ± 0.05 mm2 /s, 0.49 ± 0.06 mm2 /s, and 0.42 ± 0.06 mm2 /s of λ3 in group 1, group 2, and group 3, respectively; F = 1.65, p = 0.203 of λ1; F = 10.55, p < 0.001 of λ2; F = 4.21, p = 0.021 of λ3; respectively). A statistically significant difference in the λ2 value was observed between group 1 and group 3 ( p < 0.001) and group 2 and group 3 ( p = 0.005). A statistically significant difference in the λ3 value was also observed between group 1 and group 3 ( p = 0.007). No significant difference in the λ1 value was noted between each of the two groups. Conclusions Damage of the thalamus in Wilson's disease patients can be detected using DTI. DTI may provide information regarding thalamus damage in patients with Wilson's disease before abnormal signals on conventional MRI.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anisotropy</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Hepatolenticular Degeneration - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Thalamus - pathology</subject><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtaqi7lL4AxyQb-WSxR9ZbyyhSlVFAamIA6D2gGQ59mTrJbEXT1Kp_x5H23Lg0INlz_N7TzNvCHnD2Yozrt7vVi5bvxKMywKsCnREllyqdSWEvj0mS8aYrrRQbEFeIu7mshb1CVmIWkrBVbMkv74GlxOOeXLjlIFaREAcII40dXS8g3Jsb4cJaYj0JvSY4hlSHxAsAp0wxG2puq68UqQjREyZhsFuy8cr8qKzPcLrx_uU_Lz6-OPyc3X97dOXy4vrytWcj5VyGtYSLN9seKdBKNUI5qzv2taB9X6z1kpJcKyDVutGg9TOQyPbMoxTNZen5N3Bd5_TnwlwNENAB31vI6QJDa-13GjNGl2o4kCdp8YMndnn0m1-MJyZOVWzM3OqZk51xgpURG8f_ad2AP9P8hRjIXw4EKBMeR8gG3QBogMfMrjR-BSe9z__T-76EIOz_W94ANylKceSn-EGhWHm-7zIea1cMrZmism_3nmfTg</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Li, G</creator><creator>Zhou, X</creator><creator>Xu, P</creator><creator>Pan, X</creator><creator>Chen, Y</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging</title><author>Li, G ; Zhou, X ; Xu, P ; Pan, X ; Chen, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-6c9e53ea1771f9e266820cadfbbceadd759663ec0feb9989e39cde83b424c6413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anisotropy</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Hepatolenticular Degeneration - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Thalamus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, G</creatorcontrib><creatorcontrib>Zhou, X</creatorcontrib><creatorcontrib>Xu, P</creatorcontrib><creatorcontrib>Pan, X</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, G</au><au>Zhou, X</au><au>Xu, P</au><au>Pan, X</au><au>Chen, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging</atitle><jtitle>Clinical radiology</jtitle><addtitle>Clin Radiol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>69</volume><issue>3</issue><spage>294</spage><epage>298</epage><pages>294-298</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><abstract>Aim To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). Materials and methods Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (λ1), second eigenvalue (λ2), and third eigenvalue (λ3) of the thalamus were measured and the differences were compared. Results The FA values of the thalamus were different in the three groups (group 1: 0.36 ± 0.02; group 2: 0.38 ± 0.02; group 3: 0.43 ± 0.02; F = 54.51, p < 0.001). A statistically significant difference was observed between group 1 and group 2 ( p = 0.003), group 1 and group 3 ( p = 0.001), and group 2 and group 3 ( p < 0.001). The λ1, λ2, and λ3 values of the thalamus were different in the three groups (1.11 ± 0.06 mm2 /s, 1.11 ± 0.06 mm2 /s, and 1.10 ± 0.04 mm2 /s of λ1 in group 1, group 2, and group 3, respectively; 0.82 ± 0.08 mm2 /s, 0.78 ± 0.05 mm2 /s, and 0.72 ± 0.02 mm2 /s of λ2 in group 1, group 2, and group 3, respectively; 0.52 ± 0.05 mm2 /s, 0.49 ± 0.06 mm2 /s, and 0.42 ± 0.06 mm2 /s of λ3 in group 1, group 2, and group 3, respectively; F = 1.65, p = 0.203 of λ1; F = 10.55, p < 0.001 of λ2; F = 4.21, p = 0.021 of λ3; respectively). A statistically significant difference in the λ2 value was observed between group 1 and group 3 ( p < 0.001) and group 2 and group 3 ( p = 0.005). A statistically significant difference in the λ3 value was also observed between group 1 and group 3 ( p = 0.007). No significant difference in the λ1 value was noted between each of the two groups. Conclusions Damage of the thalamus in Wilson's disease patients can be detected using DTI. DTI may provide information regarding thalamus damage in patients with Wilson's disease before abnormal signals on conventional MRI.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24332168</pmid><doi>10.1016/j.crad.2013.10.016</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Anisotropy Case-Control Studies Child Diffusion Tensor Imaging Female Hepatolenticular Degeneration - pathology Humans Male Radiology Retrospective Studies Thalamus - pathology |
| title | Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging |
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