Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901

Abstract Introduction The Aurora kinases play a key role in mitosis and have recently been identified as attractive targets for therapeutic intervention in cancer. The aim of this study was therefore to investigate the utility of 3′-[18 F]fluoro-3′-deoxythymidine (FLT) and 2-deoxy-2-[18 F]fluoro-D-g...

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Veröffentlicht in:	Nuclear medicine and biology 2014-02, Vol.41 (2), p.148-154
Hauptverfasser:	Cullinane, Carleen, Waldeck, Kelly L, Binns, David, Bogatyreva, Ekaterina, Bradley, Daniel P, de Jong, Ron, McArthur, Grant A, Hicks, Rodney J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora B kinase Aurora Kinase B - antagonists & inhibitors Biological Transport - drug effects Biomarkers, Tumor - metabolism Carbolines - pharmacology Carbolines - therapeutic use Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Dideoxynucleosides - metabolism FDG-PET Female FLT-PET Fluorodeoxyglucose F18 - metabolism HCT116 Cells Humans Mice Positron-Emission Tomography - methods Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Radiology Sulfones - pharmacology Sulfones - therapeutic use TAK-901 Treatment Outcome
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