Prognosis of Intracerebral Hemorrhage after Conservative Treatment
Background The aim of this population-based study was to determine the short-term prognosis of patients treated conservatively for spontaneous intracerebral hemorrhage (ICH), a disease with a high rate of mortality. Methods During a 39-month period beginning in October 2007, 594 patients (mean age 7...
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| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2014-02, Vol.23 (2), p.230-234 |
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| description | Background The aim of this population-based study was to determine the short-term prognosis of patients treated conservatively for spontaneous intracerebral hemorrhage (ICH), a disease with a high rate of mortality. Methods During a 39-month period beginning in October 2007, 594 patients (mean age 72 ± 12 years; 52% female; median National Institutes of Health Stroke Scale [NIHSS] score 9) with spontaneous ICH were enrolled in this prospective, population-based study. Results Of 594 patients, 74 (12%) died during hospitalization (10.3 ± 7 days). Adjusted logistic regression analyses revealed that the in-hospital mortality rate was significantly associated with age >80 years (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.3-7.5; P = .01), NIHSS score >15 (OR 3.3; 95% CI 1.4-9.7; P = .007), unconsciousness at admission (OR 5.3; 95% CI 2.0-13.6; P = .001), and cerebral edema detected by cranial computed tomography at admission (OR 14.7; 95% CI 6.2-34.6; P 80 years (OR 3.5; 95% CI 1.4-8.7; P = .008), previous stroke (OR 4.1; 95% CI 1.6-10.3; P = .002), unconsciousness at admission (OR 5.7; 95% CI 2.4-13.9; P = .001), pneumonia suffered during hospitalization (OR 3.3; 95% CI 1.2-9.6; P = .02), and cerebral edema (OR 5.7; 95% CI 2.3-13.8; P |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2012.12.018 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1493795562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1052305712004454</els_id><sourcerecordid>1493795562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-76d5422708f0216be91530ad38a1042ebf9a4a2cb64ae1dba0a88ac95d65f1f33</originalsourceid><addsrcrecordid>eNqVkcFq3DAQhkVpadK0r1B8LAVvNZLltS-FZmmbwEIDSc9iLI9TObaVjrQLefto2bSH0ktgQDr8-mb0jRAfQa5AQv1pXI0xcbgjR0wdhz3G3seVkqBWuSQ0L8QpGK3KxgC8zHdpVKmlWZ-INzGOUgKYxrwWJ0prowDUqTi_4nC7hOhjEYbickmMRzpOxQXNgfkX3lKBQyIuNmGJxHtMfk_FDROmmZb0VrwacIr07uk8Ez-_fb3ZXJTbH98vN1-2patMm8p13ZtKqbVsBqmg7qjNo0rsdYMgK0Xd0GKFynV1hQR9hxKbBl1r-toMMGh9Jj4cufccfu8oJjv76GiacKGwixaqVq9bY2qVo-fHqOMQI9Ng79nPyA8WpD24tKP9n0t7cGlzZZcZ8v6p366bqf-L-CMvB7bHAOVf7z2xjc7T4qj3TC7ZPvjn9fv8D85NfvEOpzt6oDiGHS_ZrwUb8wN7fdjuYbmgpKwqU-lHvvSpCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1493795562</pqid></control><display><type>article</type><title>Prognosis of Intracerebral Hemorrhage after Conservative Treatment</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Al-Khaled, Mohamed, MD ; Eggers, Jürgen, MD</creator><creatorcontrib>Al-Khaled, Mohamed, MD ; Eggers, Jürgen, MD ; QugSS2 Study</creatorcontrib><description>Background The aim of this population-based study was to determine the short-term prognosis of patients treated conservatively for spontaneous intracerebral hemorrhage (ICH), a disease with a high rate of mortality. Methods During a 39-month period beginning in October 2007, 594 patients (mean age 72 ± 12 years; 52% female; median National Institutes of Health Stroke Scale [NIHSS] score 9) with spontaneous ICH were enrolled in this prospective, population-based study. Results Of 594 patients, 74 (12%) died during hospitalization (10.3 ± 7 days). Adjusted logistic regression analyses revealed that the in-hospital mortality rate was significantly associated with age >80 years (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.3-7.5; P = .01), NIHSS score >15 (OR 3.3; 95% CI 1.4-9.7; P = .007), unconsciousness at admission (OR 5.3; 95% CI 2.0-13.6; P = .001), and cerebral edema detected by cranial computed tomography at admission (OR 14.7; 95% CI 6.2-34.6; P < .001). At hospital discharge, 329 patients (63%) agreed to participate in the inquiry. At 3 months of follow-up, 55 (18%) of 309 patients died. The 3-month mortality rate correlated significantly with age >80 years (OR 3.5; 95% CI 1.4-8.7; P = .008), previous stroke (OR 4.1; 95% CI 1.6-10.3; P = .002), unconsciousness at admission (OR 5.7; 95% CI 2.4-13.9; P = .001), pneumonia suffered during hospitalization (OR 3.3; 95% CI 1.2-9.6; P = .02), and cerebral edema (OR 5.7; 95% CI 2.3-13.8; P < .001). Conclusions Our study may help clinicians estimate the short-term prognosis of patients treated conservatively for ICH.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2012.12.018</identifier><identifier>PMID: 23352112</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Cardiovascular ; Cerebral Hemorrhage - diagnosis ; Cerebral Hemorrhage - mortality ; Cerebral Hemorrhage - therapy ; Chi-Square Distribution ; Conservative treatment ; Disability Evaluation ; Disease Progression ; epidemiology ; Female ; Germany - epidemiology ; Hospital Mortality ; Humans ; intracerebral hemorrhage ; Logistic Models ; Male ; Middle Aged ; mortality ; Neurology ; Odds Ratio ; Patient Discharge ; prognosis ; Prospective Studies ; Risk Factors ; stroke ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2014-02, Vol.23 (2), p.230-234</ispartof><rights>National Stroke Association</rights><rights>2014 National Stroke Association</rights><rights>Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-76d5422708f0216be91530ad38a1042ebf9a4a2cb64ae1dba0a88ac95d65f1f33</citedby><cites>FETCH-LOGICAL-c459t-76d5422708f0216be91530ad38a1042ebf9a4a2cb64ae1dba0a88ac95d65f1f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1052305712004454$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23352112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Khaled, Mohamed, MD</creatorcontrib><creatorcontrib>Eggers, Jürgen, MD</creatorcontrib><creatorcontrib>QugSS2 Study</creatorcontrib><title>Prognosis of Intracerebral Hemorrhage after Conservative Treatment</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>Background The aim of this population-based study was to determine the short-term prognosis of patients treated conservatively for spontaneous intracerebral hemorrhage (ICH), a disease with a high rate of mortality. Methods During a 39-month period beginning in October 2007, 594 patients (mean age 72 ± 12 years; 52% female; median National Institutes of Health Stroke Scale [NIHSS] score 9) with spontaneous ICH were enrolled in this prospective, population-based study. Results Of 594 patients, 74 (12%) died during hospitalization (10.3 ± 7 days). Adjusted logistic regression analyses revealed that the in-hospital mortality rate was significantly associated with age >80 years (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.3-7.5; P = .01), NIHSS score >15 (OR 3.3; 95% CI 1.4-9.7; P = .007), unconsciousness at admission (OR 5.3; 95% CI 2.0-13.6; P = .001), and cerebral edema detected by cranial computed tomography at admission (OR 14.7; 95% CI 6.2-34.6; P < .001). At hospital discharge, 329 patients (63%) agreed to participate in the inquiry. At 3 months of follow-up, 55 (18%) of 309 patients died. The 3-month mortality rate correlated significantly with age >80 years (OR 3.5; 95% CI 1.4-8.7; P = .008), previous stroke (OR 4.1; 95% CI 1.6-10.3; P = .002), unconsciousness at admission (OR 5.7; 95% CI 2.4-13.9; P = .001), pneumonia suffered during hospitalization (OR 3.3; 95% CI 1.2-9.6; P = .02), and cerebral edema (OR 5.7; 95% CI 2.3-13.8; P < .001). Conclusions Our study may help clinicians estimate the short-term prognosis of patients treated conservatively for ICH.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular</subject><subject>Cerebral Hemorrhage - diagnosis</subject><subject>Cerebral Hemorrhage - mortality</subject><subject>Cerebral Hemorrhage - therapy</subject><subject>Chi-Square Distribution</subject><subject>Conservative treatment</subject><subject>Disability Evaluation</subject><subject>Disease Progression</subject><subject>epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>intracerebral hemorrhage</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Patient Discharge</subject><subject>prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>stroke</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcFq3DAQhkVpadK0r1B8LAVvNZLltS-FZmmbwEIDSc9iLI9TObaVjrQLefto2bSH0ktgQDr8-mb0jRAfQa5AQv1pXI0xcbgjR0wdhz3G3seVkqBWuSQ0L8QpGK3KxgC8zHdpVKmlWZ-INzGOUgKYxrwWJ0prowDUqTi_4nC7hOhjEYbickmMRzpOxQXNgfkX3lKBQyIuNmGJxHtMfk_FDROmmZb0VrwacIr07uk8Ez-_fb3ZXJTbH98vN1-2patMm8p13ZtKqbVsBqmg7qjNo0rsdYMgK0Xd0GKFynV1hQR9hxKbBl1r-toMMGh9Jj4cufccfu8oJjv76GiacKGwixaqVq9bY2qVo-fHqOMQI9Ng79nPyA8WpD24tKP9n0t7cGlzZZcZ8v6p366bqf-L-CMvB7bHAOVf7z2xjc7T4qj3TC7ZPvjn9fv8D85NfvEOpzt6oDiGHS_ZrwUb8wN7fdjuYbmgpKwqU-lHvvSpCg</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Al-Khaled, Mohamed, MD</creator><creator>Eggers, Jürgen, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Prognosis of Intracerebral Hemorrhage after Conservative Treatment</title><author>Al-Khaled, Mohamed, MD ; Eggers, Jürgen, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-76d5422708f0216be91530ad38a1042ebf9a4a2cb64ae1dba0a88ac95d65f1f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular</topic><topic>Cerebral Hemorrhage - diagnosis</topic><topic>Cerebral Hemorrhage - mortality</topic><topic>Cerebral Hemorrhage - therapy</topic><topic>Chi-Square Distribution</topic><topic>Conservative treatment</topic><topic>Disability Evaluation</topic><topic>Disease Progression</topic><topic>epidemiology</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>intracerebral hemorrhage</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Patient Discharge</topic><topic>prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>stroke</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Khaled, Mohamed, MD</creatorcontrib><creatorcontrib>Eggers, Jürgen, MD</creatorcontrib><creatorcontrib>QugSS2 Study</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Khaled, Mohamed, MD</au><au>Eggers, Jürgen, MD</au><aucorp>QugSS2 Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis of Intracerebral Hemorrhage after Conservative Treatment</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>23</volume><issue>2</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>Background The aim of this population-based study was to determine the short-term prognosis of patients treated conservatively for spontaneous intracerebral hemorrhage (ICH), a disease with a high rate of mortality. Methods During a 39-month period beginning in October 2007, 594 patients (mean age 72 ± 12 years; 52% female; median National Institutes of Health Stroke Scale [NIHSS] score 9) with spontaneous ICH were enrolled in this prospective, population-based study. Results Of 594 patients, 74 (12%) died during hospitalization (10.3 ± 7 days). Adjusted logistic regression analyses revealed that the in-hospital mortality rate was significantly associated with age >80 years (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.3-7.5; P = .01), NIHSS score >15 (OR 3.3; 95% CI 1.4-9.7; P = .007), unconsciousness at admission (OR 5.3; 95% CI 2.0-13.6; P = .001), and cerebral edema detected by cranial computed tomography at admission (OR 14.7; 95% CI 6.2-34.6; P < .001). At hospital discharge, 329 patients (63%) agreed to participate in the inquiry. At 3 months of follow-up, 55 (18%) of 309 patients died. The 3-month mortality rate correlated significantly with age >80 years (OR 3.5; 95% CI 1.4-8.7; P = .008), previous stroke (OR 4.1; 95% CI 1.6-10.3; P = .002), unconsciousness at admission (OR 5.7; 95% CI 2.4-13.9; P = .001), pneumonia suffered during hospitalization (OR 3.3; 95% CI 1.2-9.6; P = .02), and cerebral edema (OR 5.7; 95% CI 2.3-13.8; P < .001). Conclusions Our study may help clinicians estimate the short-term prognosis of patients treated conservatively for ICH.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23352112</pmid><doi>10.1016/j.jstrokecerebrovasdis.2012.12.018</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Cardiovascular Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - mortality Cerebral Hemorrhage - therapy Chi-Square Distribution Conservative treatment Disability Evaluation Disease Progression epidemiology Female Germany - epidemiology Hospital Mortality Humans intracerebral hemorrhage Logistic Models Male Middle Aged mortality Neurology Odds Ratio Patient Discharge prognosis Prospective Studies Risk Factors stroke Time Factors Tomography, X-Ray Computed Treatment Outcome |
| title | Prognosis of Intracerebral Hemorrhage after Conservative Treatment |
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