Human CD14+CTLA‐4+ regulatory dendritic cells suppress T‐cell response by cytotoxic T‐lymphocyte antigen‐4‐dependent IL‐10 and indoleamine‐2,3‐dioxygenase production in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. HCC‐induced immunosuppression often leads to ineffectiveness of immuno‐promoting therapies. Currently, suppressing the suppressors has become the potential strategy for cancer immunother...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-02, Vol.59 (2), p.567-579
Hauptverfasser:	Han, Yanmei, Chen, Zhubo, Yang, Yuan, Jiang, Zhengping, Gu, Yan, Liu, Yangfang, Lin, Chuan, Pan, Zeya, Yu, Yizhi, Jiang, Minghong, Zhou, Weiping, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Case-Control Studies CD11b Antigen - metabolism CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CTLA-4 Antigen - metabolism Cytotoxicity Dendritic Cells - metabolism Dendritic Cells - pathology Disease Progression Female Hepatology Humans Immune system Immunosuppression Immunotherapy In Vitro Techniques Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Interleukin-10 - metabolism Leukocytes, Mononuclear - pathology Lipopolysaccharide Receptors - metabolism Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Phenotype Programmed Cell Death 1 Receptor - metabolism T cell receptors Young Adult
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