A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32
The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, al...
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| Veröffentlicht in: | The Journal of immunology (1950) 1987-01, Vol.138 (1), p.312-315 |
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| container_end_page | 315 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 138 |
| creator | Weis, JH Morton, CC Bruns, GA Weis, JJ Klickstein, LB Wong, WW Fearon, DT |
| description | The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32. |
| doi_str_mv | 10.4049/jimmunol.138.1.312 |
| format | Article |
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In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.</description><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Complement</subject><subject>Epstein-Barr virus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes</subject><subject>Humans</subject><subject>Molecular immunology</subject><subject>Nucleic Acid Hybridization</subject><subject>Receptors, Complement - genetics</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi0EKtvCH0BC8gFxy-74I4nDraxaQKrEBc6WY0-2ruw4tZOu-PcEdemeRpp55p3RQ8gHBlsJsts9-BiXMYUtE2rLtoLxV2TD6hqqpoHmNdkAcF6xtmnfkstSHgCgAS4vyIVoFVfANyRcU5viFDDiONOMFqc5ZRqSXcoXesARC8XRJufHA92LfreX_Rkzo1ubbnczlRn9WH01OdMnn5dyZqKZ6JwoexT8HXkzmFDw_alekd-3N7_236u7n99-7K_vKiuBzxXvuOv7jkklnYSaNwJNrwbkogVnDKKoQYFzomuU49bxtqvbVijbqUFKZOKKfH7OnXJ6XLDMOvpiMQQzYlqKZrITolGwgvwZtDmVknHQU_bR5D-agf6nWP9XrFfFmulV8br08ZS-9BHdy8rJ6Tr_dJqbYk0YshmtLy-Ygo4Lxc9P3vvD_dFn1CWaENZQpo_H4_neXyzLkn4</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Weis, JH</creator><creator>Morton, CC</creator><creator>Bruns, GA</creator><creator>Weis, JJ</creator><creator>Klickstein, LB</creator><creator>Wong, WW</creator><creator>Fearon, DT</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19870101</creationdate><title>A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32</title><author>Weis, JH ; Morton, CC ; Bruns, GA ; Weis, JJ ; Klickstein, LB ; Wong, WW ; Fearon, DT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-292dbb91484d405263eab8fe2370daaee35080dd3968d2cd27957738c98f44e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Complement</topic><topic>Epstein-Barr virus</topic><topic>Fundamental and applied biological sciences. 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| ispartof | The Journal of immunology (1950), 1987-01, Vol.138 (1), p.312-315 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 1 Complement Epstein-Barr virus Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Humans Molecular immunology Nucleic Acid Hybridization Receptors, Complement - genetics |
| title | A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32 |
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