Selective Destruction of Cultured Dopaminergic Neurons from Fetal Rat Mesencephalon by 1‐Methyl‐4‐Phenylpyridinium: Cytochemical and Morphological Evidence

: Dopaminergic neurons in cultures of dissociated cells from fetal rat mesencephalon were exposed to the principal metabolite of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), 1‐methyl‐4‐phenyl‐pyridinium ion (MPP+), and several of its structural analogues. At concentrations bet...

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Veröffentlicht in:	Journal of neurochemistry 1988-06, Vol.50 (6), p.1934-1944
Hauptverfasser:	Sanchez‐Ramos, Juan R., Michel, Patrick, Weiner, William J., Hefti, Franz
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Animals Antioxidants Antioxidants - pharmacology Biological and medical sciences Catecholamines - metabolism Cell cultures Cell morphology Cells, Cultured Dopamine Dopamine - physiology Fundamental and applied biological sciences. Psychology Histocytochemistry Immunoenzyme Techniques Kinetics Mesencephalon - cytology Mesencephalon - embryology Microscopy, Fluorescence Molecular and cellular biology Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxicity Neurotoxins Paraquat Pyridinium Compounds - pharmacology Rats Tyrosine 3-Monooxygenase - metabolism
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