Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients
The study was performed on 13 asthmatic patients to determine whether inhaled dipyridamole would act directly by inducing bronchoconstriction or indirectly by potentiating the adenosine‐induced bronchoconstriction. The study was performed in 3 consecutive days. On the first day adenosine challenge w...
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| Veröffentlicht in: | Allergy (Copenhagen) 1988-04, Vol.43 (3), p.179-183 |
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| container_title | Allergy (Copenhagen) |
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| creator | Crimi, N. Palermo, F. Oliveri, R. Maccarrone, C. Palermo, B. Vancheri, C. Polosa, R. Mistretta, A. |
| description | The study was performed on 13 asthmatic patients to determine whether inhaled dipyridamole would act directly by inducing bronchoconstriction or indirectly by potentiating the adenosine‐induced bronchoconstriction. The study was performed in 3 consecutive days. On the first day adenosine challenge was performed and the PD20 value calculated. On the other days the adenosine challenge was done 5 min after randomized inhalations of dipyridamole or a control solution. The mean percent change in FEV1 after dipyridamole (Δ%= 2.0) and control solution (Δ%= 1.0) was not significant. Inhaled adenosine caused bronchoconstriction with a geometric mean PD20 of 1.09 mg. After control solution inhalation, a mean PD20 value of 1.31 mg was observed. Dipyridamole inhalation increased adenosine hyperresponsiveness and in all subjects shifted the dose‐response curves of adenosine challenge to the left with a mean PD20 value of 0.40 mg. This enhancing effect of dipyridamole was significant when compared with the baseline value (P < 0.01) and control solution (P < 0.O1). The study demonstrated that dipyridamole inhalation increased airway responsiveness to adenosine in all subjects. This effect is due to indirect activity of dipyridamole on airways without changes in baseline airway caliber. |
| doi_str_mv | 10.1111/j.1398-9995.1988.tb00416.x |
| format | Article |
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The study was performed in 3 consecutive days. On the first day adenosine challenge was performed and the PD20 value calculated. On the other days the adenosine challenge was done 5 min after randomized inhalations of dipyridamole or a control solution. The mean percent change in FEV1 after dipyridamole (Δ%= 2.0) and control solution (Δ%= 1.0) was not significant. Inhaled adenosine caused bronchoconstriction with a geometric mean PD20 of 1.09 mg. After control solution inhalation, a mean PD20 value of 1.31 mg was observed. Dipyridamole inhalation increased adenosine hyperresponsiveness and in all subjects shifted the dose‐response curves of adenosine challenge to the left with a mean PD20 value of 0.40 mg. This enhancing effect of dipyridamole was significant when compared with the baseline value (P < 0.01) and control solution (P < 0.O1). The study demonstrated that dipyridamole inhalation increased airway responsiveness to adenosine in all subjects. This effect is due to indirect activity of dipyridamole on airways without changes in baseline airway caliber.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.1988.tb00416.x</identifier><identifier>PMID: 3377142</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adenosine ; Adenosine - metabolism ; Adenosine - pharmacology ; adenosine‐induced bronchospasm ; Administration, Inhalation ; Adolescent ; Adult ; airway hyperresponsiveness ; Allergic diseases ; Asthma - physiopathology ; Biological and medical sciences ; Bronchi - drug effects ; Bronchi - physiopathology ; Bronchial Spasm - chemically induced ; dipyridamole ; Dipyridamole - pharmacology ; Drug Synergism ; Female ; Humans ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Respiratory and ent allergic diseases</subject><ispartof>Allergy (Copenhagen), 1988-04, Vol.43 (3), p.179-183</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4299-7e09ee6b35546761dad1ef63ba772dd5d513897325724d6ddee626c829e95ece3</citedby><cites>FETCH-LOGICAL-c4299-7e09ee6b35546761dad1ef63ba772dd5d513897325724d6ddee626c829e95ece3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.1988.tb00416.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.1988.tb00416.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7630890$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3377142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crimi, N.</creatorcontrib><creatorcontrib>Palermo, F.</creatorcontrib><creatorcontrib>Oliveri, R.</creatorcontrib><creatorcontrib>Maccarrone, C.</creatorcontrib><creatorcontrib>Palermo, B.</creatorcontrib><creatorcontrib>Vancheri, C.</creatorcontrib><creatorcontrib>Polosa, R.</creatorcontrib><creatorcontrib>Mistretta, A.</creatorcontrib><title>Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>The study was performed on 13 asthmatic patients to determine whether inhaled dipyridamole would act directly by inducing bronchoconstriction or indirectly by potentiating the adenosine‐induced bronchoconstriction. The study was performed in 3 consecutive days. On the first day adenosine challenge was performed and the PD20 value calculated. On the other days the adenosine challenge was done 5 min after randomized inhalations of dipyridamole or a control solution. The mean percent change in FEV1 after dipyridamole (Δ%= 2.0) and control solution (Δ%= 1.0) was not significant. Inhaled adenosine caused bronchoconstriction with a geometric mean PD20 of 1.09 mg. After control solution inhalation, a mean PD20 value of 1.31 mg was observed. Dipyridamole inhalation increased adenosine hyperresponsiveness and in all subjects shifted the dose‐response curves of adenosine challenge to the left with a mean PD20 value of 0.40 mg. This enhancing effect of dipyridamole was significant when compared with the baseline value (P < 0.01) and control solution (P < 0.O1). The study demonstrated that dipyridamole inhalation increased airway responsiveness to adenosine in all subjects. This effect is due to indirect activity of dipyridamole on airways without changes in baseline airway caliber.</description><subject>adenosine</subject><subject>Adenosine - metabolism</subject><subject>Adenosine - pharmacology</subject><subject>adenosine‐induced bronchospasm</subject><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>airway hyperresponsiveness</subject><subject>Allergic diseases</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - physiopathology</subject><subject>Bronchial Spasm - chemically induced</subject><subject>dipyridamole</subject><subject>Dipyridamole - pharmacology</subject><subject>Drug Synergism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Respiratory and ent allergic diseases</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1q3DAURkVJSaZpHyFgSujOjmRZkpVFYAjpDwx0k6yFLF13NNiSa3lIZtdHyDPmSSIzZvYVQlp857sSB6GvBBckrZtdQaiscyklK4is62JqMK4IL14-oNUpOkMrTDDLK0brC_Qpxh3GWJQSn6NzSoUgVblC8OC32hvn_2TQtmCmLLSZdcNhdFb3oYPMJaDTkws-S1tb8CE6D2__Xp23ewM2a8bgzTbEQcc-4ZmO07ZPDZMN6QQ_xc_oY6u7CF-W-xI9fX94vP-Zb37_-HW_3uSmKqXMBWAJwBvKWMUFJ1ZbAi2njRaitJZZRmgtBS2ZKCvLrU1wyU1dSpAMDNBL9O04dxjD3z3ESfUuGug67SHsoyKVpFhwlsDbI2jGEOMIrRpG1-vxoAhWs2O1U7NINYtUs2O1OFYvqXy1vLJverCn6iI15ddLrqPRXTvOguMJE5ziWuKE3R2xZ9fB4T8-oNabDRGSvgNJ9pv6</recordid><startdate>198804</startdate><enddate>198804</enddate><creator>Crimi, N.</creator><creator>Palermo, F.</creator><creator>Oliveri, R.</creator><creator>Maccarrone, C.</creator><creator>Palermo, B.</creator><creator>Vancheri, C.</creator><creator>Polosa, R.</creator><creator>Mistretta, A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>198804</creationdate><title>Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients</title><author>Crimi, N. ; Palermo, F. ; Oliveri, R. ; Maccarrone, C. ; Palermo, B. ; Vancheri, C. ; Polosa, R. ; Mistretta, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4299-7e09ee6b35546761dad1ef63ba772dd5d513897325724d6ddee626c829e95ece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>adenosine</topic><topic>Adenosine - metabolism</topic><topic>Adenosine - pharmacology</topic><topic>adenosine‐induced bronchospasm</topic><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>airway hyperresponsiveness</topic><topic>Allergic diseases</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchi - drug effects</topic><topic>Bronchi - physiopathology</topic><topic>Bronchial Spasm - chemically induced</topic><topic>dipyridamole</topic><topic>Dipyridamole - pharmacology</topic><topic>Drug Synergism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Respiratory and ent allergic diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crimi, N.</creatorcontrib><creatorcontrib>Palermo, F.</creatorcontrib><creatorcontrib>Oliveri, R.</creatorcontrib><creatorcontrib>Maccarrone, C.</creatorcontrib><creatorcontrib>Palermo, B.</creatorcontrib><creatorcontrib>Vancheri, C.</creatorcontrib><creatorcontrib>Polosa, R.</creatorcontrib><creatorcontrib>Mistretta, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crimi, N.</au><au>Palermo, F.</au><au>Oliveri, R.</au><au>Maccarrone, C.</au><au>Palermo, B.</au><au>Vancheri, C.</au><au>Polosa, R.</au><au>Mistretta, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>1988-04</date><risdate>1988</risdate><volume>43</volume><issue>3</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>The study was performed on 13 asthmatic patients to determine whether inhaled dipyridamole would act directly by inducing bronchoconstriction or indirectly by potentiating the adenosine‐induced bronchoconstriction. The study was performed in 3 consecutive days. On the first day adenosine challenge was performed and the PD20 value calculated. On the other days the adenosine challenge was done 5 min after randomized inhalations of dipyridamole or a control solution. The mean percent change in FEV1 after dipyridamole (Δ%= 2.0) and control solution (Δ%= 1.0) was not significant. Inhaled adenosine caused bronchoconstriction with a geometric mean PD20 of 1.09 mg. After control solution inhalation, a mean PD20 value of 1.31 mg was observed. Dipyridamole inhalation increased adenosine hyperresponsiveness and in all subjects shifted the dose‐response curves of adenosine challenge to the left with a mean PD20 value of 0.40 mg. This enhancing effect of dipyridamole was significant when compared with the baseline value (P < 0.01) and control solution (P < 0.O1). The study demonstrated that dipyridamole inhalation increased airway responsiveness to adenosine in all subjects. This effect is due to indirect activity of dipyridamole on airways without changes in baseline airway caliber.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3377142</pmid><doi>10.1111/j.1398-9995.1988.tb00416.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-4538 |
| ispartof | Allergy (Copenhagen), 1988-04, Vol.43 (3), p.179-183 |
| issn | 0105-4538 1398-9995 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | adenosine Adenosine - metabolism Adenosine - pharmacology adenosine‐induced bronchospasm Administration, Inhalation Adolescent Adult airway hyperresponsiveness Allergic diseases Asthma - physiopathology Biological and medical sciences Bronchi - drug effects Bronchi - physiopathology Bronchial Spasm - chemically induced dipyridamole Dipyridamole - pharmacology Drug Synergism Female Humans Immunopathology Male Medical sciences Middle Aged Respiratory and ent allergic diseases |
| title | Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients |
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