Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia
Abstract There have been few clinical studies on the association between the 24-h area under the concentration–time curve (AUC24 ) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA ba...
Gespeichert in:
| Veröffentlicht in: | International journal of antimicrobial agents 2014-02, Vol.43 (2), p.179-183 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 183 |
|---|---|
| container_issue | 2 |
| container_start_page | 179 |
| container_title | International journal of antimicrobial agents |
| container_volume | 43 |
| creator | Jung, Younghee Song, Kyoung-Ho Cho, Jeong eun Kim, Hyung-sook Kim, Nak-Hyun Kim, Taek Soo Choe, Pyoeng Gyun Chung, Jae-Yong Park, Wan Beom Bang, Ji Hwan Kim, Eu Suk Park, Kyoung Un Park, Sang-Won Kim, Hong Bin Kim, Nam Joong Oh, Myoung-don |
| description | Abstract There have been few clinical studies on the association between the 24-h area under the concentration–time curve (AUC24 ) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA bacteraemia between July 2009 and January 2012 were analysed retrospectively. All adult patients treated with vancomycin for ≥72 h without dialysis were included. The MIC was determined by Etest and broth microdilution (BMD). Initial steady-state AUC24 was estimated using a Bayesian model, and the AUC24 /MIC cut-off value for differentiating treatment success and failure was calculated by classification and regression tree (CART) analysis. In total, 76 patients were enrolled; vancomycin treatment failure occurred in 20 patients (26.3%). Catheter-related infection was the most frequent (35.5%), followed by surgical site infection (26.3%), whilst 25 (32.9%) had complicated infections. In univariate analysis, decreased MRSA vancomycin susceptibility (MIC ≥ 1.5 mg/L) and vancomycin trough levels (15–20 mg/L) were not associated with treatment outcomes. In the CART analysis, low initial vancomycin AUC24 /MIC ( |
| doi_str_mv | 10.1016/j.ijantimicag.2013.10.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492723611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0924857913003749</els_id><sourcerecordid>1492723611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-fd7fe0952d7ad4bf18ff2704d08c815aa9b0cc48a0f9d8417a84426e083f060c3</originalsourceid><addsrcrecordid>eNqNUkuOEzEQbSEQEwaugMyOTQf_OnZvkEbR8JFGYjGwthx3NanQtoPtjpQdd-A8XIaT4JABAStWJVW9j6peNc0zRpeMstWL3RJ3NhT06OzHJadM1P6SMnWvWTCteKt6Ju43C9pz2epO9RfNo5x3lLJOyO5hc8GlYJ3SetF8u0pgyRwGSKRsgbgYHISSbMEYvn_5Wk1qc04HICUSjwH97AmGLW6wxHT8m0B-FmIzsWSfYEBXMSSO5GCDi_7oMJBSDYuvFBLnUptQ1YiHskWH04ShTZAxl7ofuS12vz1O0UXn5qo5J6hlY12BZMGjfdw8GO2U4cldvWw-vLp-v37T3rx7_XZ9ddM6KXhpx0GNQPuOD8oOcjMyPY5cUTlQ7TTrrO031DmpLR37QUumrJaSr4BqMdIVdeKyeX7W3af4eYZcjMfsYJpsgDhnw2TPFRcrxiq0P0NdijknGM0-obfpaBg1p_TMzvyRnjmldxrV9Cr36Z3NvPEw_Gb-iqsC1mcA1GUPCMlkh1ADGDCBK2aI-F82L_9RcfXuFTZ9giPkXZxTqNc0zGRuqLk9vdHpi5igVCjZix-W6M48</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1492723611</pqid></control><display><type>article</type><title>Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Jung, Younghee ; Song, Kyoung-Ho ; Cho, Jeong eun ; Kim, Hyung-sook ; Kim, Nak-Hyun ; Kim, Taek Soo ; Choe, Pyoeng Gyun ; Chung, Jae-Yong ; Park, Wan Beom ; Bang, Ji Hwan ; Kim, Eu Suk ; Park, Kyoung Un ; Park, Sang-Won ; Kim, Hong Bin ; Kim, Nam Joong ; Oh, Myoung-don</creator><creatorcontrib>Jung, Younghee ; Song, Kyoung-Ho ; Cho, Jeong eun ; Kim, Hyung-sook ; Kim, Nak-Hyun ; Kim, Taek Soo ; Choe, Pyoeng Gyun ; Chung, Jae-Yong ; Park, Wan Beom ; Bang, Ji Hwan ; Kim, Eu Suk ; Park, Kyoung Un ; Park, Sang-Won ; Kim, Hong Bin ; Kim, Nam Joong ; Oh, Myoung-don</creatorcontrib><description>Abstract There have been few clinical studies on the association between the 24-h area under the concentration–time curve (AUC24 ) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA bacteraemia between July 2009 and January 2012 were analysed retrospectively. All adult patients treated with vancomycin for ≥72 h without dialysis were included. The MIC was determined by Etest and broth microdilution (BMD). Initial steady-state AUC24 was estimated using a Bayesian model, and the AUC24 /MIC cut-off value for differentiating treatment success and failure was calculated by classification and regression tree (CART) analysis. In total, 76 patients were enrolled; vancomycin treatment failure occurred in 20 patients (26.3%). Catheter-related infection was the most frequent (35.5%), followed by surgical site infection (26.3%), whilst 25 (32.9%) had complicated infections. In univariate analysis, decreased MRSA vancomycin susceptibility (MIC ≥ 1.5 mg/L) and vancomycin trough levels (15–20 mg/L) were not associated with treatment outcomes. In the CART analysis, low initial vancomycin AUC24 /MIC (<430 by Etest; <398.5 by BMD) was associated with a higher treatment failure rate (50.0% vs. 25.0%, P = 0.039 by Etest; 45.0% vs. 23.2%; P = 0.065 by BMD). In multivariate analysis, low initial vancomycin AUC24 /MIC was a significant risk factor for treatment failure [adjusted odds ratio (aOR) = 4.39, 95% confidence interval (CI), 1.26–15.35 by Etest; aOR = 3.73, 95% CI 1.10–12.61 by BMD]. In MRSA bacteraemia, a low initial vancomycin AUC24 /MIC is an independent risk factor for vancomycin treatment failure.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2013.10.017</identifier><identifier>PMID: 24315788</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Area Under Curve ; Area under the concentration–time curve ; Bacteraemia ; Bacteremia - drug therapy ; Bacteremia - microbiology ; Female ; Humans ; Infectious Disease ; Male ; Methicillin-resistant Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Middle Aged ; Minimum inhibitory concentration ; Plasma - chemistry ; Retrospective Studies ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Treatment Outcome ; Vancomycin ; Vancomycin - administration & dosage ; Vancomycin - pharmacokinetics ; Vancomycin - pharmacology</subject><ispartof>International journal of antimicrobial agents, 2014-02, Vol.43 (2), p.179-183</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2013 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>Copyright © 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-fd7fe0952d7ad4bf18ff2704d08c815aa9b0cc48a0f9d8417a84426e083f060c3</citedby><cites>FETCH-LOGICAL-c432t-fd7fe0952d7ad4bf18ff2704d08c815aa9b0cc48a0f9d8417a84426e083f060c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2013.10.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24315788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Younghee</creatorcontrib><creatorcontrib>Song, Kyoung-Ho</creatorcontrib><creatorcontrib>Cho, Jeong eun</creatorcontrib><creatorcontrib>Kim, Hyung-sook</creatorcontrib><creatorcontrib>Kim, Nak-Hyun</creatorcontrib><creatorcontrib>Kim, Taek Soo</creatorcontrib><creatorcontrib>Choe, Pyoeng Gyun</creatorcontrib><creatorcontrib>Chung, Jae-Yong</creatorcontrib><creatorcontrib>Park, Wan Beom</creatorcontrib><creatorcontrib>Bang, Ji Hwan</creatorcontrib><creatorcontrib>Kim, Eu Suk</creatorcontrib><creatorcontrib>Park, Kyoung Un</creatorcontrib><creatorcontrib>Park, Sang-Won</creatorcontrib><creatorcontrib>Kim, Hong Bin</creatorcontrib><creatorcontrib>Kim, Nam Joong</creatorcontrib><creatorcontrib>Oh, Myoung-don</creatorcontrib><title>Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Abstract There have been few clinical studies on the association between the 24-h area under the concentration–time curve (AUC24 ) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA bacteraemia between July 2009 and January 2012 were analysed retrospectively. All adult patients treated with vancomycin for ≥72 h without dialysis were included. The MIC was determined by Etest and broth microdilution (BMD). Initial steady-state AUC24 was estimated using a Bayesian model, and the AUC24 /MIC cut-off value for differentiating treatment success and failure was calculated by classification and regression tree (CART) analysis. In total, 76 patients were enrolled; vancomycin treatment failure occurred in 20 patients (26.3%). Catheter-related infection was the most frequent (35.5%), followed by surgical site infection (26.3%), whilst 25 (32.9%) had complicated infections. In univariate analysis, decreased MRSA vancomycin susceptibility (MIC ≥ 1.5 mg/L) and vancomycin trough levels (15–20 mg/L) were not associated with treatment outcomes. In the CART analysis, low initial vancomycin AUC24 /MIC (<430 by Etest; <398.5 by BMD) was associated with a higher treatment failure rate (50.0% vs. 25.0%, P = 0.039 by Etest; 45.0% vs. 23.2%; P = 0.065 by BMD). In multivariate analysis, low initial vancomycin AUC24 /MIC was a significant risk factor for treatment failure [adjusted odds ratio (aOR) = 4.39, 95% confidence interval (CI), 1.26–15.35 by Etest; aOR = 3.73, 95% CI 1.10–12.61 by BMD]. In MRSA bacteraemia, a low initial vancomycin AUC24 /MIC is an independent risk factor for vancomycin treatment failure.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Area Under Curve</subject><subject>Area under the concentration–time curve</subject><subject>Bacteraemia</subject><subject>Bacteremia - drug therapy</subject><subject>Bacteremia - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Male</subject><subject>Methicillin-resistant Staphylococcus aureus</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Minimum inhibitory concentration</subject><subject>Plasma - chemistry</subject><subject>Retrospective Studies</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Treatment Outcome</subject><subject>Vancomycin</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - pharmacokinetics</subject><subject>Vancomycin - pharmacology</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUkuOEzEQbSEQEwaugMyOTQf_OnZvkEbR8JFGYjGwthx3NanQtoPtjpQdd-A8XIaT4JABAStWJVW9j6peNc0zRpeMstWL3RJ3NhT06OzHJadM1P6SMnWvWTCteKt6Ju43C9pz2epO9RfNo5x3lLJOyO5hc8GlYJ3SetF8u0pgyRwGSKRsgbgYHISSbMEYvn_5Wk1qc04HICUSjwH97AmGLW6wxHT8m0B-FmIzsWSfYEBXMSSO5GCDi_7oMJBSDYuvFBLnUptQ1YiHskWH04ShTZAxl7ofuS12vz1O0UXn5qo5J6hlY12BZMGjfdw8GO2U4cldvWw-vLp-v37T3rx7_XZ9ddM6KXhpx0GNQPuOD8oOcjMyPY5cUTlQ7TTrrO031DmpLR37QUumrJaSr4BqMdIVdeKyeX7W3af4eYZcjMfsYJpsgDhnw2TPFRcrxiq0P0NdijknGM0-obfpaBg1p_TMzvyRnjmldxrV9Cr36Z3NvPEw_Gb-iqsC1mcA1GUPCMlkh1ADGDCBK2aI-F82L_9RcfXuFTZ9giPkXZxTqNc0zGRuqLk9vdHpi5igVCjZix-W6M48</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Jung, Younghee</creator><creator>Song, Kyoung-Ho</creator><creator>Cho, Jeong eun</creator><creator>Kim, Hyung-sook</creator><creator>Kim, Nak-Hyun</creator><creator>Kim, Taek Soo</creator><creator>Choe, Pyoeng Gyun</creator><creator>Chung, Jae-Yong</creator><creator>Park, Wan Beom</creator><creator>Bang, Ji Hwan</creator><creator>Kim, Eu Suk</creator><creator>Park, Kyoung Un</creator><creator>Park, Sang-Won</creator><creator>Kim, Hong Bin</creator><creator>Kim, Nam Joong</creator><creator>Oh, Myoung-don</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia</title><author>Jung, Younghee ; Song, Kyoung-Ho ; Cho, Jeong eun ; Kim, Hyung-sook ; Kim, Nak-Hyun ; Kim, Taek Soo ; Choe, Pyoeng Gyun ; Chung, Jae-Yong ; Park, Wan Beom ; Bang, Ji Hwan ; Kim, Eu Suk ; Park, Kyoung Un ; Park, Sang-Won ; Kim, Hong Bin ; Kim, Nam Joong ; Oh, Myoung-don</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-fd7fe0952d7ad4bf18ff2704d08c815aa9b0cc48a0f9d8417a84426e083f060c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Area Under Curve</topic><topic>Area under the concentration–time curve</topic><topic>Bacteraemia</topic><topic>Bacteremia - drug therapy</topic><topic>Bacteremia - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Male</topic><topic>Methicillin-resistant Staphylococcus aureus</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Minimum inhibitory concentration</topic><topic>Plasma - chemistry</topic><topic>Retrospective Studies</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Treatment Outcome</topic><topic>Vancomycin</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - pharmacokinetics</topic><topic>Vancomycin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Younghee</creatorcontrib><creatorcontrib>Song, Kyoung-Ho</creatorcontrib><creatorcontrib>Cho, Jeong eun</creatorcontrib><creatorcontrib>Kim, Hyung-sook</creatorcontrib><creatorcontrib>Kim, Nak-Hyun</creatorcontrib><creatorcontrib>Kim, Taek Soo</creatorcontrib><creatorcontrib>Choe, Pyoeng Gyun</creatorcontrib><creatorcontrib>Chung, Jae-Yong</creatorcontrib><creatorcontrib>Park, Wan Beom</creatorcontrib><creatorcontrib>Bang, Ji Hwan</creatorcontrib><creatorcontrib>Kim, Eu Suk</creatorcontrib><creatorcontrib>Park, Kyoung Un</creatorcontrib><creatorcontrib>Park, Sang-Won</creatorcontrib><creatorcontrib>Kim, Hong Bin</creatorcontrib><creatorcontrib>Kim, Nam Joong</creatorcontrib><creatorcontrib>Oh, Myoung-don</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of antimicrobial agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Younghee</au><au>Song, Kyoung-Ho</au><au>Cho, Jeong eun</au><au>Kim, Hyung-sook</au><au>Kim, Nak-Hyun</au><au>Kim, Taek Soo</au><au>Choe, Pyoeng Gyun</au><au>Chung, Jae-Yong</au><au>Park, Wan Beom</au><au>Bang, Ji Hwan</au><au>Kim, Eu Suk</au><au>Park, Kyoung Un</au><au>Park, Sang-Won</au><au>Kim, Hong Bin</au><au>Kim, Nam Joong</au><au>Oh, Myoung-don</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>43</volume><issue>2</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>Abstract There have been few clinical studies on the association between the 24-h area under the concentration–time curve (AUC24 ) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA bacteraemia between July 2009 and January 2012 were analysed retrospectively. All adult patients treated with vancomycin for ≥72 h without dialysis were included. The MIC was determined by Etest and broth microdilution (BMD). Initial steady-state AUC24 was estimated using a Bayesian model, and the AUC24 /MIC cut-off value for differentiating treatment success and failure was calculated by classification and regression tree (CART) analysis. In total, 76 patients were enrolled; vancomycin treatment failure occurred in 20 patients (26.3%). Catheter-related infection was the most frequent (35.5%), followed by surgical site infection (26.3%), whilst 25 (32.9%) had complicated infections. In univariate analysis, decreased MRSA vancomycin susceptibility (MIC ≥ 1.5 mg/L) and vancomycin trough levels (15–20 mg/L) were not associated with treatment outcomes. In the CART analysis, low initial vancomycin AUC24 /MIC (<430 by Etest; <398.5 by BMD) was associated with a higher treatment failure rate (50.0% vs. 25.0%, P = 0.039 by Etest; 45.0% vs. 23.2%; P = 0.065 by BMD). In multivariate analysis, low initial vancomycin AUC24 /MIC was a significant risk factor for treatment failure [adjusted odds ratio (aOR) = 4.39, 95% confidence interval (CI), 1.26–15.35 by Etest; aOR = 3.73, 95% CI 1.10–12.61 by BMD]. In MRSA bacteraemia, a low initial vancomycin AUC24 /MIC is an independent risk factor for vancomycin treatment failure.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24315788</pmid><doi>10.1016/j.ijantimicag.2013.10.017</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2014-02, Vol.43 (2), p.179-183 |
| issn | 0924-8579 1872-7913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1492723611 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Area Under Curve Area under the concentration–time curve Bacteraemia Bacteremia - drug therapy Bacteremia - microbiology Female Humans Infectious Disease Male Methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Middle Aged Minimum inhibitory concentration Plasma - chemistry Retrospective Studies Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Treatment Outcome Vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics Vancomycin - pharmacology |
| title | Area under the concentration–time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T21%3A11%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Area%20under%20the%20concentration%E2%80%93time%20curve%20to%20minimum%20inhibitory%20concentration%20ratio%20as%20a%20predictor%20of%20vancomycin%20treatment%20outcome%20in%20methicillin-resistant%20Staphylococcus%20aureus%20bacteraemia&rft.jtitle=International%20journal%20of%20antimicrobial%20agents&rft.au=Jung,%20Younghee&rft.date=2014-02-01&rft.volume=43&rft.issue=2&rft.spage=179&rft.epage=183&rft.pages=179-183&rft.issn=0924-8579&rft.eissn=1872-7913&rft_id=info:doi/10.1016/j.ijantimicag.2013.10.017&rft_dat=%3Cproquest_cross%3E1492723611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1492723611&rft_id=info:pmid/24315788&rft_els_id=S0924857913003749&rfr_iscdi=true |