Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia
Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients w...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2014-03, Vol.52 (3), p.445-451 |
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| creator | Kao, Shang-Jyh Chuang, Chun-Yi Tang, Chih-Hsin Lin, Chien-Huang Bien, Mauo-Ying Yu, Ming-Chih Bai, Kuan-Jen Yang, Shun-Fa Chien, Ming-Hsien |
| description | Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).
Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients.
Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r=0.554, p |
| doi_str_mv | 10.1515/cclm-2013-0638 |
| format | Article |
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Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients.
Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r=0.554, p<0.001), CURB-65 (r=0.510, p<0.001), and APACHE II scores (r=0.447, p<0.001).
Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2013-0638</identifier><identifier>PMID: 24108208</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; biochemical marker ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Community-Acquired Infections - blood ; Community-Acquired Infections - drug therapy ; community-acquired pneumonia ; Cytokines ; endothelial cell-specific molecule-1 ; Endothelial cells ; Endothelium ; Enzyme-linked immunosorbent assay ; Growth factors ; Hospitalization ; Humans ; Inflammation ; Leukocyte Count ; Leukocytes ; Leukocytes (neutrophilic) ; Male ; Middle Aged ; Neoplasm Proteins - blood ; Patients ; Plasma ; Plasma levels ; Pneumonia ; Pneumonia - blood ; Pneumonia - drug therapy ; pneumonia severity index ; Proteoglycans ; Proteoglycans - blood ; Sepsis ; Serum levels ; Treatment Outcome</subject><ispartof>Clinical chemistry and laboratory medicine, 2014-03, Vol.52 (3), p.445-451</ispartof><rights>2014 by Walter de Gruyter Berlin Boston</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-faa7ae107e032acc950f6e0252ed447155d117c6a00bbeedd99db822c5d26c643</citedby><cites>FETCH-LOGICAL-c376t-faa7ae107e032acc950f6e0252ed447155d117c6a00bbeedd99db822c5d26c643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2013-0638/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2013-0638/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24108208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kao, Shang-Jyh</creatorcontrib><creatorcontrib>Chuang, Chun-Yi</creatorcontrib><creatorcontrib>Tang, Chih-Hsin</creatorcontrib><creatorcontrib>Lin, Chien-Huang</creatorcontrib><creatorcontrib>Bien, Mauo-Ying</creatorcontrib><creatorcontrib>Yu, Ming-Chih</creatorcontrib><creatorcontrib>Bai, Kuan-Jen</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Chien, Ming-Hsien</creatorcontrib><title>Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).
Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients.
Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r=0.554, p<0.001), CURB-65 (r=0.510, p<0.001), and APACHE II scores (r=0.447, p<0.001).
Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>biochemical marker</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Community-Acquired Infections - blood</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>community-acquired pneumonia</subject><subject>Cytokines</subject><subject>endothelial cell-specific molecule-1</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Growth factors</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - blood</subject><subject>Patients</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Pneumonia</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - drug therapy</subject><subject>pneumonia severity index</subject><subject>Proteoglycans</subject><subject>Proteoglycans - blood</subject><subject>Sepsis</subject><subject>Serum levels</subject><subject>Treatment Outcome</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtrVTEQh4Mo9qFblxJwUxepeedccFNKrUJFQV2H3GROTcnj9uQEuf-953irgriaWXzzm5kPoReMnjPF1BvvUyacMkGoFsMjdMykMEQKwR7_6iXRmrMjdNLaHaVMKWmeoiMuGR04HY6R-5xcyw5DCXX-Dim6hD2kRNoOfByjx7km8D0BYfjs6stHwl7jWHB2xd1ChjLjOmJfc-4lznvi_H2PEwS8K9BzLdE9Q09Glxo8f6in6Nu7q6-X78nNp-sPlxc3xAujZzI6ZxwwaoAK7rzfKDpqoFxxCFKa5fLAmPHaUbrdAoSw2YTtwLlXgWuvpThFZ4fc3VTvO7TZ5tjWV1yB2ptlcsMN54NgC_rqH_Su9qks11muFDNKaqEW6vxA-am2NsFod1PMbtpbRu0q367y7SrfrvKXgZcPsX2bIfzBf9tegLcH4IdLM0wBbqe-X5q_6_-frLiQUomfEHGTMQ</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Kao, Shang-Jyh</creator><creator>Chuang, Chun-Yi</creator><creator>Tang, Chih-Hsin</creator><creator>Lin, Chien-Huang</creator><creator>Bien, Mauo-Ying</creator><creator>Yu, Ming-Chih</creator><creator>Bai, Kuan-Jen</creator><creator>Yang, Shun-Fa</creator><creator>Chien, Ming-Hsien</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia</title><author>Kao, Shang-Jyh ; Chuang, Chun-Yi ; Tang, Chih-Hsin ; Lin, Chien-Huang ; Bien, Mauo-Ying ; Yu, Ming-Chih ; Bai, Kuan-Jen ; Yang, Shun-Fa ; Chien, Ming-Hsien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-faa7ae107e032acc950f6e0252ed447155d117c6a00bbeedd99db822c5d26c643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>biochemical marker</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Community-Acquired Infections - blood</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>community-acquired pneumonia</topic><topic>Cytokines</topic><topic>endothelial cell-specific molecule-1</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Growth factors</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Leukocytes (neutrophilic)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - blood</topic><topic>Patients</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Pneumonia</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - drug therapy</topic><topic>pneumonia severity index</topic><topic>Proteoglycans</topic><topic>Proteoglycans - blood</topic><topic>Sepsis</topic><topic>Serum levels</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kao, Shang-Jyh</creatorcontrib><creatorcontrib>Chuang, Chun-Yi</creatorcontrib><creatorcontrib>Tang, Chih-Hsin</creatorcontrib><creatorcontrib>Lin, Chien-Huang</creatorcontrib><creatorcontrib>Bien, Mauo-Ying</creatorcontrib><creatorcontrib>Yu, Ming-Chih</creatorcontrib><creatorcontrib>Bai, Kuan-Jen</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Chien, Ming-Hsien</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kao, Shang-Jyh</au><au>Chuang, Chun-Yi</au><au>Tang, Chih-Hsin</au><au>Lin, Chien-Huang</au><au>Bien, Mauo-Ying</au><au>Yu, Ming-Chih</au><au>Bai, Kuan-Jen</au><au>Yang, Shun-Fa</au><au>Chien, Ming-Hsien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>52</volume><issue>3</issue><spage>445</spage><epage>451</epage><pages>445-451</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).
Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients.
Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r=0.554, p<0.001), CURB-65 (r=0.510, p<0.001), and APACHE II scores (r=0.447, p<0.001).
Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>24108208</pmid><doi>10.1515/cclm-2013-0638</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical chemistry and laboratory medicine, 2014-03, Vol.52 (3), p.445-451 |
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| source | MEDLINE; De Gruyter journals |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Antibiotics biochemical marker Biomarkers - blood C-reactive protein C-Reactive Protein - analysis Community-Acquired Infections - blood Community-Acquired Infections - drug therapy community-acquired pneumonia Cytokines endothelial cell-specific molecule-1 Endothelial cells Endothelium Enzyme-linked immunosorbent assay Growth factors Hospitalization Humans Inflammation Leukocyte Count Leukocytes Leukocytes (neutrophilic) Male Middle Aged Neoplasm Proteins - blood Patients Plasma Plasma levels Pneumonia Pneumonia - blood Pneumonia - drug therapy pneumonia severity index Proteoglycans Proteoglycans - blood Sepsis Serum levels Treatment Outcome |
| title | Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia |
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