A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness

This study tests the hypothesis that the mannose receptor (MR/CD206), which is expressed primarily by macrophages and dendritic cells, can be found in a soluble form (sMR, sMR) in human serum. Furthermore, we wished to establish and validate an enzyme-linked immunosorbent assay (ELISA) for sMR and t...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2014-03, Vol.52 (3), p.453-461
Hauptverfasser:	Rødgaard-Hansen, Sidsel, Rafique, Aisha, Christensen, Peter A., Maniecki, Maciej B., Sandahl, Thomas D., Nexø, Ebba, Møller, Holger Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarker Biomarkers Biomarkers - blood Biomarkers - chemistry CD206 Critical Illness Dendritic cells Enzyme-Linked Immunosorbent Assay hepatitis Hospitalization Humans Lectins, C-Type - blood Lectins, C-Type - chemistry Liver liver disease Liver diseases M2 macrophage Macrophages Mannose Mannose-Binding Lectins - blood Mannose-Binding Lectins - chemistry Middle Aged Proteins Receptors Receptors, Cell Surface - blood Receptors, Cell Surface - chemistry Reference Values Reproducibility of Results sCD206 Sepsis sMR Solubility soluble mannose receptor Western blotting
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