Anxiolytic- like effects of phytol: Possible involvement of GABAergic transmission
Abstract Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic- like effects of phytol in animal models to clarify their possible action mech...
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| Veröffentlicht in: | Brain research 2014-02, Vol.1547, p.34-42 |
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| creator | Costa, Jéssica Pereira de Oliveira, Guilherme Antônio L de Almeida, Antônia Amanda C Islam, Md.Torequl de Sousa, Damião Pergentino de Freitas, Rivelilson Mendes |
| description | Abstract Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic- like effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light–dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [ p |
| doi_str_mv | 10.1016/j.brainres.2013.12.003 |
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The aim of this study was to evaluate the anxiolytic- like effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light–dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [ p <0.01] increased the number of crossings and rearings. However, the number of groomings [ p <0.01] was reduced. Likewise, the number of entries and the time spent in light space were increased [ p <0.01] while the number of marble-burying was decreased [ p <0.001], in elevated-plus-maze, light–dark and marble-burying tests, respectively. In motor activity test, phytol (75 mg/kg) impaired the rota-rod performance of mice [ p <0.01]. In pentobarbital sleeping time test, phytol 75 mg/kg decreased for latency of sleeping and phytol (25, 50 and 75 mg/kg) increased the sleep time when compared to negative control [ p <0.05]. All these effects were reversed by pre-treatment with flumazenil (2.5 mg/kg, i.p.), similarly to those observed with diazepam (2 mg/kg, i.p.; positive control) suggesting that the phytol presents mechanism of action by interaction with the GABAergic system. These findings suggest that acute administration of phytol exerts an anxiolytic- like effect on mice. Furthermore, suppose that phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects, to produce sedative and anxiolytic activities.]]></description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2013.12.003</identifier><identifier>PMID: 24333358</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Anxiety Agents - administration & dosage ; Anti-Anxiety Agents - pharmacology ; Anxiolytic-like ; Behavior, Animal - drug effects ; Biological and medical sciences ; Elevated-plus-maze ; Flumazenil - pharmacology ; GABA Modulators - pharmacology ; Hypnotics. Sedatives ; Light–dark ; Male ; Marble-burying ; Maze Learning - drug effects ; Medical sciences ; Mice ; Motor Activity - drug effects ; Neurology ; Neuropharmacology ; Pentobarbital sleeping time ; Pharmacology. Drug treatments ; Phytol ; Phytol - administration & dosage ; Phytol - pharmacology ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Sleep - drug effects</subject><ispartof>Brain research, 2014-02, Vol.1547, p.34-42</ispartof><rights>2013</rights><rights>2015 INIST-CNRS</rights><rights>2013 Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-e08dcb00dce0f0b9f2e5644d12d92e7b6d5a39a7347bb05a801e68963df335f13</citedby><cites>FETCH-LOGICAL-c501t-e08dcb00dce0f0b9f2e5644d12d92e7b6d5a39a7347bb05a801e68963df335f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2013.12.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28696904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24333358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Jéssica Pereira</creatorcontrib><creatorcontrib>de Oliveira, Guilherme Antônio L</creatorcontrib><creatorcontrib>de Almeida, Antônia Amanda C</creatorcontrib><creatorcontrib>Islam, Md.Torequl</creatorcontrib><creatorcontrib>de Sousa, Damião Pergentino</creatorcontrib><creatorcontrib>de Freitas, Rivelilson Mendes</creatorcontrib><title>Anxiolytic- like effects of phytol: Possible involvement of GABAergic transmission</title><title>Brain research</title><addtitle>Brain Res</addtitle><description><![CDATA[Abstract Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic- like effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light–dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [ p <0.01] increased the number of crossings and rearings. However, the number of groomings [ p <0.01] was reduced. Likewise, the number of entries and the time spent in light space were increased [ p <0.01] while the number of marble-burying was decreased [ p <0.001], in elevated-plus-maze, light–dark and marble-burying tests, respectively. In motor activity test, phytol (75 mg/kg) impaired the rota-rod performance of mice [ p <0.01]. In pentobarbital sleeping time test, phytol 75 mg/kg decreased for latency of sleeping and phytol (25, 50 and 75 mg/kg) increased the sleep time when compared to negative control [ p <0.05]. All these effects were reversed by pre-treatment with flumazenil (2.5 mg/kg, i.p.), similarly to those observed with diazepam (2 mg/kg, i.p.; positive control) suggesting that the phytol presents mechanism of action by interaction with the GABAergic system. These findings suggest that acute administration of phytol exerts an anxiolytic- like effect on mice. Furthermore, suppose that phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects, to produce sedative and anxiolytic activities.]]></description><subject>Animals</subject><subject>Anti-Anxiety Agents - administration & dosage</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anxiolytic-like</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Elevated-plus-maze</subject><subject>Flumazenil - pharmacology</subject><subject>GABA Modulators - pharmacology</subject><subject>Hypnotics. Sedatives</subject><subject>Light–dark</subject><subject>Male</subject><subject>Marble-burying</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pentobarbital sleeping time</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytol</subject><subject>Phytol - administration & dosage</subject><subject>Phytol - pharmacology</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Sleep - drug effects</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAQgC0EYkvhL6xyQeKSMrYTJ-aAKCtYkFYC8ThbjjMGd127a6cV_fc4ahckLvhiWfPNw98QcklhRYGKl5vVkLQLCfOKAeUrylYA_AFZ0L5jtWANPCQLABB1LyW_IE9y3pQn5xIekwvW8HLafkG-rMMvF_1xcqauvLvFCq1FM-Uq2mr38zhF_6r6HHN2g8fKhUP0B9ximOb49frtGtMPZ6op6ZC3rmAxPCWPrPYZn53vJfn-_t23qw_1zafrj1frm9q0QKcaoR_NADAaBAuDtAxb0TQjZaNk2A1ibDWXuuNNNwzQ6h4oil4KPtoyuqV8SV6c6u5SvNtjnlQZwKD3OmDcZ0UbyToqoOMFFSfUpPKVhFbtktvqdFQU1OxTbdS9TzX7VJSp2daSXJ577Ictjn_S7gUW4PkZ0Nlob4sH4_JfrhdSSGgK9-bEYTFycJhUNg6DwdGloluN0f1_ltf_lDDeBVe63uIR8ybuUyi-FVW5JKiv8_bn5VMOtOXQ898RK6vm</recordid><startdate>20140214</startdate><enddate>20140214</enddate><creator>Costa, Jéssica Pereira</creator><creator>de Oliveira, Guilherme Antônio L</creator><creator>de Almeida, Antônia Amanda C</creator><creator>Islam, Md.Torequl</creator><creator>de Sousa, Damião Pergentino</creator><creator>de Freitas, Rivelilson Mendes</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140214</creationdate><title>Anxiolytic- like effects of phytol: Possible involvement of GABAergic transmission</title><author>Costa, Jéssica Pereira ; de Oliveira, Guilherme Antônio L ; de Almeida, Antônia Amanda C ; Islam, Md.Torequl ; de Sousa, Damião Pergentino ; de Freitas, Rivelilson Mendes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-e08dcb00dce0f0b9f2e5644d12d92e7b6d5a39a7347bb05a801e68963df335f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - administration & dosage</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Anxiolytic-like</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Elevated-plus-maze</topic><topic>Flumazenil - pharmacology</topic><topic>GABA Modulators - pharmacology</topic><topic>Hypnotics. Sedatives</topic><topic>Light–dark</topic><topic>Male</topic><topic>Marble-burying</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pentobarbital sleeping time</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytol</topic><topic>Phytol - administration & dosage</topic><topic>Phytol - pharmacology</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Sleep - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Jéssica Pereira</creatorcontrib><creatorcontrib>de Oliveira, Guilherme Antônio L</creatorcontrib><creatorcontrib>de Almeida, Antônia Amanda C</creatorcontrib><creatorcontrib>Islam, Md.Torequl</creatorcontrib><creatorcontrib>de Sousa, Damião Pergentino</creatorcontrib><creatorcontrib>de Freitas, Rivelilson Mendes</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Jéssica Pereira</au><au>de Oliveira, Guilherme Antônio L</au><au>de Almeida, Antônia Amanda C</au><au>Islam, Md.Torequl</au><au>de Sousa, Damião Pergentino</au><au>de Freitas, Rivelilson Mendes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiolytic- like effects of phytol: Possible involvement of GABAergic transmission</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2014-02-14</date><risdate>2014</risdate><volume>1547</volume><spage>34</spage><epage>42</epage><pages>34-42</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract><![CDATA[Abstract Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic- like effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light–dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [ p <0.01] increased the number of crossings and rearings. However, the number of groomings [ p <0.01] was reduced. Likewise, the number of entries and the time spent in light space were increased [ p <0.01] while the number of marble-burying was decreased [ p <0.001], in elevated-plus-maze, light–dark and marble-burying tests, respectively. In motor activity test, phytol (75 mg/kg) impaired the rota-rod performance of mice [ p <0.01]. In pentobarbital sleeping time test, phytol 75 mg/kg decreased for latency of sleeping and phytol (25, 50 and 75 mg/kg) increased the sleep time when compared to negative control [ p <0.05]. All these effects were reversed by pre-treatment with flumazenil (2.5 mg/kg, i.p.), similarly to those observed with diazepam (2 mg/kg, i.p.; positive control) suggesting that the phytol presents mechanism of action by interaction with the GABAergic system. These findings suggest that acute administration of phytol exerts an anxiolytic- like effect on mice. Furthermore, suppose that phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects, to produce sedative and anxiolytic activities.]]></abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>24333358</pmid><doi>10.1016/j.brainres.2013.12.003</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Anxiety Agents - administration & dosage Anti-Anxiety Agents - pharmacology Anxiolytic-like Behavior, Animal - drug effects Biological and medical sciences Elevated-plus-maze Flumazenil - pharmacology GABA Modulators - pharmacology Hypnotics. Sedatives Light–dark Male Marble-burying Maze Learning - drug effects Medical sciences Mice Motor Activity - drug effects Neurology Neuropharmacology Pentobarbital sleeping time Pharmacology. Drug treatments Phytol Phytol - administration & dosage Phytol - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sleep - drug effects |
| title | Anxiolytic- like effects of phytol: Possible involvement of GABAergic transmission |
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