Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle
•Expression profiles of LncRNAs between brown adipose tissue and skeletal muscle.•704 up-regulated and 896 down-regulated lncRNAs were identified.•Analysis of dysregulated LncRNAs.•AK003288 may affect energy metabolism.•Find new therapeutic target for combatting obesity. Both brown adipose tissue an...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2014-01, Vol.443 (3), p.1028-1034 |
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| creator | Zhang, Jun Cui, Xianwei Shen, Yahui Pang, Lingxia Zhang, Aiqing Fu, Ziyi Chen, Jiantao Guo, Xirong Gan, Weihua Ji, Chenbo |
| description | •Expression profiles of LncRNAs between brown adipose tissue and skeletal muscle.•704 up-regulated and 896 down-regulated lncRNAs were identified.•Analysis of dysregulated LncRNAs.•AK003288 may affect energy metabolism.•Find new therapeutic target for combatting obesity.
Both brown adipose tissue and skeletalmuscle have abundant mitochondria and energy consumption capacity. They are similar in origin and gain different potential of energy metabolism after differentiation and maturation. The mechanism that cause the difference is not yet fully understood. Long non-coding RNAs (lncRNAs) which comprise the bulk of the human non-coding transcriptome have been proved to play key roles in various biological processes. Whether they will have a function on the differentiation and energy metabolism between BAT and skeletalmuscle is still unknown. To identify the cellular long noncoding RNAs (lncRNAs) involved in the progress, we used the next generation transcriptome sequencing and microarray techniques, and investigated 704 up-regulated and 896 down-regulated lncRNAs (fold-change >3.0) in BAT by comparing the expression profile. Furthermore, we reported AK003288 associated with junctophilin 2 (Jph2) gene which may affect energy metabolism. This study show distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle which provide information for further research on differentiation of adipocyte and transdifferentiation between BAT and skeletalmuscle that will be helpful to find a new therapeutic target for combatting obesity. |
| doi_str_mv | 10.1016/j.bbrc.2013.12.092 |
| format | Article |
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Both brown adipose tissue and skeletalmuscle have abundant mitochondria and energy consumption capacity. They are similar in origin and gain different potential of energy metabolism after differentiation and maturation. The mechanism that cause the difference is not yet fully understood. Long non-coding RNAs (lncRNAs) which comprise the bulk of the human non-coding transcriptome have been proved to play key roles in various biological processes. Whether they will have a function on the differentiation and energy metabolism between BAT and skeletalmuscle is still unknown. To identify the cellular long noncoding RNAs (lncRNAs) involved in the progress, we used the next generation transcriptome sequencing and microarray techniques, and investigated 704 up-regulated and 896 down-regulated lncRNAs (fold-change >3.0) in BAT by comparing the expression profile. Furthermore, we reported AK003288 associated with junctophilin 2 (Jph2) gene which may affect energy metabolism. This study show distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle which provide information for further research on differentiation of adipocyte and transdifferentiation between BAT and skeletalmuscle that will be helpful to find a new therapeutic target for combatting obesity.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2013.12.092</identifier><identifier>PMID: 24365148</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue, Brown - metabolism ; Animals ; Brown adipose tissue ; Computational Biology ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Humans ; Long non-coding RNA ; Mice ; Mice, Inbred C57BL ; Microarray ; Muscle, Skeletal - metabolism ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Signal Transduction - genetics ; Skeletal muscle</subject><ispartof>Biochemical and biophysical research communications, 2014-01, Vol.443 (3), p.1028-1034</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-4a45b1ad0bb0390f50155d3ca979e876a699f299320e3755076c6db63db325033</citedby><cites>FETCH-LOGICAL-c422t-4a45b1ad0bb0390f50155d3ca979e876a699f299320e3755076c6db63db325033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2013.12.092$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24365148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Cui, Xianwei</creatorcontrib><creatorcontrib>Shen, Yahui</creatorcontrib><creatorcontrib>Pang, Lingxia</creatorcontrib><creatorcontrib>Zhang, Aiqing</creatorcontrib><creatorcontrib>Fu, Ziyi</creatorcontrib><creatorcontrib>Chen, Jiantao</creatorcontrib><creatorcontrib>Guo, Xirong</creatorcontrib><creatorcontrib>Gan, Weihua</creatorcontrib><creatorcontrib>Ji, Chenbo</creatorcontrib><title>Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>•Expression profiles of LncRNAs between brown adipose tissue and skeletal muscle.•704 up-regulated and 896 down-regulated lncRNAs were identified.•Analysis of dysregulated LncRNAs.•AK003288 may affect energy metabolism.•Find new therapeutic target for combatting obesity.
Both brown adipose tissue and skeletalmuscle have abundant mitochondria and energy consumption capacity. They are similar in origin and gain different potential of energy metabolism after differentiation and maturation. The mechanism that cause the difference is not yet fully understood. Long non-coding RNAs (lncRNAs) which comprise the bulk of the human non-coding transcriptome have been proved to play key roles in various biological processes. Whether they will have a function on the differentiation and energy metabolism between BAT and skeletalmuscle is still unknown. To identify the cellular long noncoding RNAs (lncRNAs) involved in the progress, we used the next generation transcriptome sequencing and microarray techniques, and investigated 704 up-regulated and 896 down-regulated lncRNAs (fold-change >3.0) in BAT by comparing the expression profile. Furthermore, we reported AK003288 associated with junctophilin 2 (Jph2) gene which may affect energy metabolism. This study show distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle which provide information for further research on differentiation of adipocyte and transdifferentiation between BAT and skeletalmuscle that will be helpful to find a new therapeutic target for combatting obesity.</description><subject>Adipose Tissue, Brown - metabolism</subject><subject>Animals</subject><subject>Brown adipose tissue</subject><subject>Computational Biology</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Gene Ontology</subject><subject>Humans</subject><subject>Long non-coding RNA</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microarray</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Signal Transduction - genetics</subject><subject>Skeletal muscle</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAURa2qFUwpf6CLystukj7bsYMlNohCW2lEJUQldpY_XiRPM8nULynl35PRQJes3ubcq_sOYx8F1AKE-bKpQyixliBULWQNVr5hKwEWKimgectWAGAqacX9MXtPtAEQojH2iB3LRhktmrMVu_-aacpDnDj-2xUkyuPAd2Xsco_Ex46vh3h7c0E84PSAOPBQxoeB-5R3IyGfMtGM3A-J02_scfI9384Ue_zA3nW-Jzx9vifs1_XV3eX3av3z24_Li3UVGymnqvGNDsInCAGUhU6D0Dqp6G1r8aw13ljbSWuVBFSt1tCaaFIwKgUlNSh1wj4fepfRf2akyW0zRex7P-A4kxONla3QVssFlQc0lpGoYOd2JW99eXQC3N6o27i9Ubc36oR0i9El9Om5fw5bTP8jLwoX4PwA4PLl34zFUcw4REy5YJxcGvNr_U8DJobk</recordid><startdate>20140117</startdate><enddate>20140117</enddate><creator>Zhang, Jun</creator><creator>Cui, Xianwei</creator><creator>Shen, Yahui</creator><creator>Pang, Lingxia</creator><creator>Zhang, Aiqing</creator><creator>Fu, Ziyi</creator><creator>Chen, Jiantao</creator><creator>Guo, Xirong</creator><creator>Gan, Weihua</creator><creator>Ji, Chenbo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140117</creationdate><title>Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle</title><author>Zhang, Jun ; Cui, Xianwei ; Shen, Yahui ; Pang, Lingxia ; Zhang, Aiqing ; Fu, Ziyi ; Chen, Jiantao ; Guo, Xirong ; Gan, Weihua ; Ji, Chenbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-4a45b1ad0bb0390f50155d3ca979e876a699f299320e3755076c6db63db325033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipose Tissue, Brown - metabolism</topic><topic>Animals</topic><topic>Brown adipose tissue</topic><topic>Computational Biology</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Gene Ontology</topic><topic>Humans</topic><topic>Long non-coding RNA</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microarray</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Signal Transduction - genetics</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Cui, Xianwei</creatorcontrib><creatorcontrib>Shen, Yahui</creatorcontrib><creatorcontrib>Pang, Lingxia</creatorcontrib><creatorcontrib>Zhang, Aiqing</creatorcontrib><creatorcontrib>Fu, Ziyi</creatorcontrib><creatorcontrib>Chen, Jiantao</creatorcontrib><creatorcontrib>Guo, Xirong</creatorcontrib><creatorcontrib>Gan, Weihua</creatorcontrib><creatorcontrib>Ji, Chenbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jun</au><au>Cui, Xianwei</au><au>Shen, Yahui</au><au>Pang, Lingxia</au><au>Zhang, Aiqing</au><au>Fu, Ziyi</au><au>Chen, Jiantao</au><au>Guo, Xirong</au><au>Gan, Weihua</au><au>Ji, Chenbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2014-01-17</date><risdate>2014</risdate><volume>443</volume><issue>3</issue><spage>1028</spage><epage>1034</epage><pages>1028-1034</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>•Expression profiles of LncRNAs between brown adipose tissue and skeletal muscle.•704 up-regulated and 896 down-regulated lncRNAs were identified.•Analysis of dysregulated LncRNAs.•AK003288 may affect energy metabolism.•Find new therapeutic target for combatting obesity.
Both brown adipose tissue and skeletalmuscle have abundant mitochondria and energy consumption capacity. They are similar in origin and gain different potential of energy metabolism after differentiation and maturation. The mechanism that cause the difference is not yet fully understood. Long non-coding RNAs (lncRNAs) which comprise the bulk of the human non-coding transcriptome have been proved to play key roles in various biological processes. Whether they will have a function on the differentiation and energy metabolism between BAT and skeletalmuscle is still unknown. To identify the cellular long noncoding RNAs (lncRNAs) involved in the progress, we used the next generation transcriptome sequencing and microarray techniques, and investigated 704 up-regulated and 896 down-regulated lncRNAs (fold-change >3.0) in BAT by comparing the expression profile. Furthermore, we reported AK003288 associated with junctophilin 2 (Jph2) gene which may affect energy metabolism. This study show distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle which provide information for further research on differentiation of adipocyte and transdifferentiation between BAT and skeletalmuscle that will be helpful to find a new therapeutic target for combatting obesity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24365148</pmid><doi>10.1016/j.bbrc.2013.12.092</doi><tpages>7</tpages></addata></record> |
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| subjects | Adipose Tissue, Brown - metabolism Animals Brown adipose tissue Computational Biology Gene Expression Profiling Gene Expression Regulation Gene Ontology Humans Long non-coding RNA Mice Mice, Inbred C57BL Microarray Muscle, Skeletal - metabolism Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction - genetics Skeletal muscle |
| title | Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle |
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