Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β

•VEGF injection to mice caused not only angiogenesis but also fibrosis in the liver.•VEGF injection to mice caused the activation of hepatic stellate cells (HSCs).•Liver endothelial cell (LEC) culture medium, but not VEGF, directly activated HSCs.•LEC culture medium had high levels of latent transfo...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-01, Vol.443 (3), p.950-956
Hauptverfasser:	Sakata, Kotaro, Eda, Satoshi, Lee, Eun-Seo, Hara, Mitsuko, Imoto, Masaya, Kojima, Soichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - drug effects Cell Membrane - metabolism Culture Media, Conditioned - pharmacology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Hepatic Stellate Cells Kallikreins - blood Liver Cirrhosis - blood Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver fibrosis Liver sinusoidal endothelial cells Male Mice Mice, Inbred C57BL Models, Biological Neovascularization, Pathologic - blood Neovascularization, Pathologic - complications Neovascularization, Pathologic - metabolism Transforming Growth Factor beta - metabolism Transforming growth factor-β Vascular Endothelial Growth Factor A - administration & dosage
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