Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic frameworks.

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Veröffentlicht in:Organic & biomolecular chemistry 2014-02, Vol.12 (8), p.1245-1249
Hauptverfasser: Noël, R, Gembus, V, Levacher, V, Brière, J-F
Format: Artikel
Sprache:eng
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Zusammenfassung:An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic frameworks.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob42406e