Voltage-gated calcium channels function as Ca2+-activated signaling receptors

•The Ca2+-bound voltage-gated channel operates as a Ca2+ binding receptor.•A Ca2+-bound channel triggers synchronous release prior to Ca2+ influx.•A conformational change is conveyed from the channel to syntaxin 1A via intramembrane signaling.•A Ca2+-bound channel drives cardiac contraction in neona...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2014-02, Vol.39 (2), p.45-52
1. Verfasser:	Atlas, Daphne
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Calcium - metabolism Calcium Channels, L-Type - chemistry Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Calcium Signaling - physiology cardiac channel cardiac contraction Excitation Contraction Coupling - physiology Exocytosis Gene Expression Humans Ion Channel Gating - physiology Myocardial Contraction - physiology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Protein Binding Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism ryanodine receptor Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism RyR2 SNAREs Synaptic Transmission - physiology synaptotagmin Synaptotagmin I - genetics Synaptotagmin I - metabolism syntaxin Syntaxin 1 - genetics Syntaxin 1 - metabolism transmitter release
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