AS1069562, the (+)-Isomer of Indeloxazine, Exerts Analgesic Effects in a Rat Model of Neuropathic Pain with Unique Characteristics in Spinal Monoamine Turnover

AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment of cerebrovascular diseases with multiple pharmacological actions, including serotonin (5-HT) and norepinephrine (NE) reuptake inhibition. H...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-03, Vol.348 (3), p.372-382
Hauptverfasser:	Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Sekizawa, Toshihiro, Kakimoto, Shuichiro, Tsukamoto, Mina, Oe, Tomoya, Enomoto, Ryugo, Hamakawa, Nozomu, Matsuoka, Nobuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - pharmacology Analgesics - pharmacokinetics Analgesics - pharmacology Analgesics - therapeutic use Animals Biogenic Monoamines - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Duloxetine Hydrochloride Gastric Emptying - drug effects HEK293 Cells Humans Male Morpholines - pharmacokinetics Morpholines - pharmacology Morpholines - therapeutic use Motor Activity - drug effects Neuralgia - drug therapy Neuralgia - physiopathology Norepinephrine - metabolism Norepinephrine Plasma Membrane Transport Proteins - metabolism Protein Binding Rats Rats, Sprague-Dawley Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Spinal Cord - drug effects Spinal Cord - metabolism Stereoisomerism Thiophenes - pharmacokinetics Thiophenes - pharmacology
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