Adiponectin is associated with dynamic hyperinflation and a favourable response to inhaled glucocorticoids in patients with COPD

Summary Objectives Adipokines are protein mediators first described as products of adipose tissue regulating energy metabolism and appetite. Recently, adipokines have also been found to modulate inflammation and smooth muscle cell responses. Therefore we investigated the association of two adipokine...

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Veröffentlicht in:	Respiratory medicine 2014-01, Vol.108 (1), p.122-128
Hauptverfasser:	Leivo-Korpela, Sirpa, Lehtimäki, Lauri, Vuolteenaho, Katriina, Nieminen, Riina, Kööbi, Lea, Järvenpää, Ritva, Kankaanranta, Hannu, Saarelainen, Seppo, Moilanen, Eeva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines Adiponectin Adiponectin - blood Adipose Tissue - physiopathology Administration, Inhalation Androstadienes - administration & dosage Androstadienes - therapeutic use Asthma Biomarkers - blood Body mass index Bronchodilator Agents - administration & dosage Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) Diabetes Disease Emphysema Fluticasone Glucocorticoid Glucocorticoids - administration & dosage Glucocorticoids - therapeutic use Humans Hyperinflation Leptin Leptin - blood Lungs Male Plethysmography, Whole Body Predictive Value of Tests Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary emphysema Pulmonary/Respiratory Rheumatic diseases Risk Factors Rodents Sensitivity and Specificity Smoking - adverse effects Smooth muscle Spirometry Surveys and Questionnaires Tomography Treatment Outcome
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