Overexpression of AIOLOS inhibits cell proliferation and suppresses apoptosis in Nalm-6 cells

The AIOLOS gene is important in the control of mature B-lymphocyte differentiation and proliferation. Previous research has shown that deregulated AIOLOS expression is associated with adult B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia in human patients. However, the fun...

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Veröffentlicht in:	Oncology reports 2014-03, Vol.31 (3), p.1183-1190
Hauptverfasser:	ZHUANG, YONG, LI, DONG, FU, JINQIU, SHI, QING, LU, YUANYUAN, JU, XIULI
Format:	Artikel
Sprache:	eng
Schlagworte:	acute leukemia Acute lymphocytic leukemia AIOLOS Analysis Apoptosis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Care and treatment Cell cycle Cell growth Cell Proliferation Cyclin D3 - genetics Cyclin D3 - metabolism Deoxyribonucleic acid DNA G1 Phase Cell Cycle Checkpoints Gene Expression Genetic aspects Humans Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism K562 Cells lentivirus Leukemia Pathogenesis Plasmids Polymerase chain reaction Proteins Transcription factors
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