KAI1 inhibits lymphangiogenesis and lymphatic metastasis of pancreatic cancer in vivo

BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MI...

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Veröffentlicht in:	Hepatobiliary & pancreatic diseases international 2014-02, Vol.13 (1), p.87-92
Hauptverfasser:	Liu, Xu, Guo, Xiao-Zhong, Li, Hong-Yu, Chen, Jiang, Ren, Li-Nan, Wu, Chun-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals cancer Cell Line, Tumor Disease Models, Animal Endocrinology & Metabolism Gastroenterology and Hepatology Gene Expression Regulation, Neoplastic - drug effects Heterografts Humans KAI1 Kangai-1 Protein - pharmacology Kangai-1 Protein - therapeutic use lymphangiogenesis Lymphangiogenesis - drug effects lymphatic lymphatic metastasis Lymphatic Metastasis - prevention & control metastasis Mice Mice, Nude pancreatic pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Vascular Endothelial Growth Factor C - metabolism Xenograft Model Antitumor Assays
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