Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐Hodgkin lymphomas
Summary Angiogenesis is involved in the pathogenesis and progression of non‐Hodgkin lymphomas (NHL), and hypoxia‐inducible factor‐1α (HIF‐1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with a...
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| Veröffentlicht in: | British journal of haematology 2013-12, Vol.163 (5), p.640-645 |
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| creator | Minoia, Carla Quero, Carmela Asselti, Mariaconsilia Galise, Ida Marzano, Alessia L. Iacobazzi, Angela Rana, Antonio Merchionne, Francesca Serratì, Simona De Tullio, Giacoma Quintana, Giovanni Casiello, Michela Maiorano, Eugenio Simone, Giovanni Zito, Francesco A. Iacopino, Pasquale Guarini, Attilio |
| description | Summary
Angiogenesis is involved in the pathogenesis and progression of non‐Hodgkin lymphomas (NHL), and hypoxia‐inducible factor‐1α (HIF‐1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression. |
| doi_str_mv | 10.1111/bjh.12560 |
| format | Article |
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Angiogenesis is involved in the pathogenesis and progression of non‐Hodgkin lymphomas (NHL), and hypoxia‐inducible factor‐1α (HIF‐1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.12560</identifier><identifier>PMID: 24033233</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Aged ; angiogenesis ; Biological and medical sciences ; Biopsy ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Hematologic and hematopoietic diseases ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis ; Hypoxia-Inducible Factor 1, alpha Subunit - genetics ; hypoxia‐inducible factor‐1α ; indolent non‐Hodgkin lymphomas ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymph Nodes - pathology ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - metabolism ; Lymphoma, Follicular - physiopathology ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - metabolism ; Lymphoma, Non-Hodgkin - physiopathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Neovascularization, Pathologic - etiology ; Neovascularization, Pathologic - metabolism ; pathogenesis ; Recurrence ; relapse/progression ; Tumors</subject><ispartof>British journal of haematology, 2013-12, Vol.163 (5), p.640-645</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.12560$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.12560$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27961530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24033233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minoia, Carla</creatorcontrib><creatorcontrib>Quero, Carmela</creatorcontrib><creatorcontrib>Asselti, Mariaconsilia</creatorcontrib><creatorcontrib>Galise, Ida</creatorcontrib><creatorcontrib>Marzano, Alessia L.</creatorcontrib><creatorcontrib>Iacobazzi, Angela</creatorcontrib><creatorcontrib>Rana, Antonio</creatorcontrib><creatorcontrib>Merchionne, Francesca</creatorcontrib><creatorcontrib>Serratì, Simona</creatorcontrib><creatorcontrib>De Tullio, Giacoma</creatorcontrib><creatorcontrib>Quintana, Giovanni</creatorcontrib><creatorcontrib>Casiello, Michela</creatorcontrib><creatorcontrib>Maiorano, Eugenio</creatorcontrib><creatorcontrib>Simone, Giovanni</creatorcontrib><creatorcontrib>Zito, Francesco A.</creatorcontrib><creatorcontrib>Iacopino, Pasquale</creatorcontrib><creatorcontrib>Guarini, Attilio</creatorcontrib><title>Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐Hodgkin lymphomas</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Angiogenesis is involved in the pathogenesis and progression of non‐Hodgkin lymphomas (NHL), and hypoxia‐inducible factor‐1α (HIF‐1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.</description><subject>Adult</subject><subject>Aged</subject><subject>angiogenesis</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>hypoxia‐inducible factor‐1α</subject><subject>indolent non‐Hodgkin lymphomas</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - metabolism</subject><subject>Lymphoma, Follicular - physiopathology</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - metabolism</subject><subject>Lymphoma, Non-Hodgkin - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neovascularization, Pathologic - etiology</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>pathogenesis</subject><subject>Recurrence</subject><subject>relapse/progression</subject><subject>Tumors</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb-O1DAQxi0E4paDghdAaZBocju2Y8cuYcWxoJNooI4cZ7Lrw7FDvKu7dHS09yq8CA_Bk-DdW6BlGs-f33yy5iPkOYULmmPZXm8vKBMSHpAF5VKUjFb0IVkAQF1SqNQZeZLSNQDlIOhjcsYq4JxxviDfV1sTNpgKF4qcuLjBgMmlXHTFdh7jrTO_vt250O2taz0WvbG7OOUW_fmjGKe4w7yJt-OEKbkYDjoTejMm7JYT9tMRn3O7ix7Drggx5OV17DZfMurnYdzGwaSn5FFvfMJnp_ecfL58-2m1Lq8-vnu_en1VjrzSUOpWVqyvWNVabpjulDRaQa1sL2spKUqLqu9AMW0721qsDUNjhFC9BlC15ufk1b1u_vrXPaZdM7hk0XsTMO5TQyvNpNCCqv9AhRLAhYKMvjih-3bArhknN5hpbv7cOQMvT4BJ1vh8lmBd-sfVWlLBD0LLe-7GeZz_zik0B6ObbHRzNLp582F9TPhvzyGgAQ</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Minoia, Carla</creator><creator>Quero, Carmela</creator><creator>Asselti, Mariaconsilia</creator><creator>Galise, Ida</creator><creator>Marzano, Alessia L.</creator><creator>Iacobazzi, Angela</creator><creator>Rana, Antonio</creator><creator>Merchionne, Francesca</creator><creator>Serratì, Simona</creator><creator>De Tullio, Giacoma</creator><creator>Quintana, Giovanni</creator><creator>Casiello, Michela</creator><creator>Maiorano, Eugenio</creator><creator>Simone, Giovanni</creator><creator>Zito, Francesco A.</creator><creator>Iacopino, Pasquale</creator><creator>Guarini, Attilio</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201312</creationdate><title>Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐Hodgkin lymphomas</title><author>Minoia, Carla ; Quero, Carmela ; Asselti, Mariaconsilia ; Galise, Ida ; Marzano, Alessia L. ; Iacobazzi, Angela ; Rana, Antonio ; Merchionne, Francesca ; Serratì, Simona ; De Tullio, Giacoma ; Quintana, Giovanni ; Casiello, Michela ; Maiorano, Eugenio ; Simone, Giovanni ; Zito, Francesco A. ; Iacopino, Pasquale ; Guarini, Attilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3490-9b642f424bc3a29d86a98078cf67661e6ce8fd0829cdcbce7a2eaa558f9008793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>angiogenesis</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</topic><topic>hypoxia‐inducible factor‐1α</topic><topic>indolent non‐Hodgkin lymphomas</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - metabolism</topic><topic>Lymphoma, Follicular - physiopathology</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Lymphoma, Non-Hodgkin - metabolism</topic><topic>Lymphoma, Non-Hodgkin - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neovascularization, Pathologic - etiology</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>pathogenesis</topic><topic>Recurrence</topic><topic>relapse/progression</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minoia, Carla</creatorcontrib><creatorcontrib>Quero, Carmela</creatorcontrib><creatorcontrib>Asselti, Mariaconsilia</creatorcontrib><creatorcontrib>Galise, Ida</creatorcontrib><creatorcontrib>Marzano, Alessia L.</creatorcontrib><creatorcontrib>Iacobazzi, Angela</creatorcontrib><creatorcontrib>Rana, Antonio</creatorcontrib><creatorcontrib>Merchionne, Francesca</creatorcontrib><creatorcontrib>Serratì, Simona</creatorcontrib><creatorcontrib>De Tullio, Giacoma</creatorcontrib><creatorcontrib>Quintana, Giovanni</creatorcontrib><creatorcontrib>Casiello, Michela</creatorcontrib><creatorcontrib>Maiorano, Eugenio</creatorcontrib><creatorcontrib>Simone, Giovanni</creatorcontrib><creatorcontrib>Zito, Francesco A.</creatorcontrib><creatorcontrib>Iacopino, Pasquale</creatorcontrib><creatorcontrib>Guarini, Attilio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minoia, Carla</au><au>Quero, Carmela</au><au>Asselti, Mariaconsilia</au><au>Galise, Ida</au><au>Marzano, Alessia L.</au><au>Iacobazzi, Angela</au><au>Rana, Antonio</au><au>Merchionne, Francesca</au><au>Serratì, Simona</au><au>De Tullio, Giacoma</au><au>Quintana, Giovanni</au><au>Casiello, Michela</au><au>Maiorano, Eugenio</au><au>Simone, Giovanni</au><au>Zito, Francesco A.</au><au>Iacopino, Pasquale</au><au>Guarini, Attilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐Hodgkin lymphomas</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2013-12</date><risdate>2013</risdate><volume>163</volume><issue>5</issue><spage>640</spage><epage>645</epage><pages>640-645</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Angiogenesis is involved in the pathogenesis and progression of non‐Hodgkin lymphomas (NHL), and hypoxia‐inducible factor‐1α (HIF‐1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24033233</pmid><doi>10.1111/bjh.12560</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged angiogenesis Biological and medical sciences Biopsy Disease Progression Female Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - genetics hypoxia‐inducible factor‐1α indolent non‐Hodgkin lymphomas Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Lymphoma, Follicular - physiopathology Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - physiopathology Male Medical sciences Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neovascularization, Pathologic - etiology Neovascularization, Pathologic - metabolism pathogenesis Recurrence relapse/progression Tumors |
| title | Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐Hodgkin lymphomas |
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