Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice
Aims This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik‐hae. Methods and Results Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high‐fat diet & DW), LGLAB (high‐fat diet &...
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| Veröffentlicht in: | Journal of applied microbiology 2014-01, Vol.116 (1), p.145-156 |
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| creator | Park, J.‐E. Oh, S.‐H. Cha, Y.‐S. |
| description | Aims
This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik‐hae.
Methods and Results
Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high‐fat diet & DW), LGLAB (high‐fat diet & Lactobacillus plantarum LG42, 1 × 107 CFU per mouse), HGLAB (high‐fat diet & L. plantarum LG42, 1 × 109 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT‐I were significantly increased in GLAB groups, whereas the level of ACC, SREBP‐1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
Conclusion
These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high‐fat‐diet‐induced obese mice.
Significance and Impact of the Study
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity. |
| doi_str_mv | 10.1111/jam.12354 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492657579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492657579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3884-e4db2836b2494c13168d3d0b98342c20a7eb9abbddbd0021ac2d47d3f3b2ad373</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS1ERUthwQsgb5BgkdZ_iZNlVZUCmooNrKNr-6Z1yc_gm6gaseEReEaeBHdmWlZI3I3v4vM59jmMvZLiROY5vYXhRCpdmifsSOqqLFRl1dPtbopSWHXInhPdCiG1KKtn7FAZqWVVqyP2YwV-nhz42PcL8XUP4wxpGfjq0igeaephxsC7NA38GrJR5BS__f756waQB_QJgZC4m8KGw5hBmPkaAr_DeH0zE48jDxHnfCGOYfFZanJIyIfo8QU76KAnfLk_j9nX9xdfzj8Uq8-XH8_PVoXXdW0KNMGpWldOmcb47cODDsI1tTbKKwEWXQPOheCCEEqCV8HYoDvtFARt9TF7u9Ndp-n7gjS3QySPff4rTgu10jSqKm1pm_9ArS0rY02V0Xc71KeJKGHXrlMcIG1aKdr7WtqcVrutJbOv97KLGzA8kg89ZODNHgDy0HcJRh_pL1eLnIC6FzrdcXexx82_HdtPZ1c76z-QNKWe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1477564746</pqid></control><display><type>article</type><title>Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Park, J.‐E. ; Oh, S.‐H. ; Cha, Y.‐S.</creator><creatorcontrib>Park, J.‐E. ; Oh, S.‐H. ; Cha, Y.‐S.</creatorcontrib><description>Aims
This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik‐hae.
Methods and Results
Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high‐fat diet & DW), LGLAB (high‐fat diet & Lactobacillus plantarum LG42, 1 × 107 CFU per mouse), HGLAB (high‐fat diet & L. plantarum LG42, 1 × 109 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT‐I were significantly increased in GLAB groups, whereas the level of ACC, SREBP‐1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
Conclusion
These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high‐fat‐diet‐induced obese mice.
Significance and Impact of the Study
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.12354</identifier><identifier>PMID: 24131682</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>antiobesity ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; gajami sik‐hae ; high‐fat diet ; Lactobacillus plantarum ; Lactobacillus plantarum LG42 ; Microbiology</subject><ispartof>Journal of applied microbiology, 2014-01, Vol.116 (1), p.145-156</ispartof><rights>2013 The Society for Applied Microbiology</rights><rights>2015 INIST-CNRS</rights><rights>2013 The Society for Applied Microbiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-e4db2836b2494c13168d3d0b98342c20a7eb9abbddbd0021ac2d47d3f3b2ad373</citedby><cites>FETCH-LOGICAL-c3884-e4db2836b2494c13168d3d0b98342c20a7eb9abbddbd0021ac2d47d3f3b2ad373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.12354$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.12354$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28028324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24131682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, J.‐E.</creatorcontrib><creatorcontrib>Oh, S.‐H.</creatorcontrib><creatorcontrib>Cha, Y.‐S.</creatorcontrib><title>Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aims
This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik‐hae.
Methods and Results
Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high‐fat diet & DW), LGLAB (high‐fat diet & Lactobacillus plantarum LG42, 1 × 107 CFU per mouse), HGLAB (high‐fat diet & L. plantarum LG42, 1 × 109 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT‐I were significantly increased in GLAB groups, whereas the level of ACC, SREBP‐1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
Conclusion
These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high‐fat‐diet‐induced obese mice.
Significance and Impact of the Study
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.</description><subject>antiobesity</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gajami sik‐hae</subject><subject>high‐fat diet</subject><subject>Lactobacillus plantarum</subject><subject>Lactobacillus plantarum LG42</subject><subject>Microbiology</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS1ERUthwQsgb5BgkdZ_iZNlVZUCmooNrKNr-6Z1yc_gm6gaseEReEaeBHdmWlZI3I3v4vM59jmMvZLiROY5vYXhRCpdmifsSOqqLFRl1dPtbopSWHXInhPdCiG1KKtn7FAZqWVVqyP2YwV-nhz42PcL8XUP4wxpGfjq0igeaephxsC7NA38GrJR5BS__f756waQB_QJgZC4m8KGw5hBmPkaAr_DeH0zE48jDxHnfCGOYfFZanJIyIfo8QU76KAnfLk_j9nX9xdfzj8Uq8-XH8_PVoXXdW0KNMGpWldOmcb47cODDsI1tTbKKwEWXQPOheCCEEqCV8HYoDvtFARt9TF7u9Ndp-n7gjS3QySPff4rTgu10jSqKm1pm_9ArS0rY02V0Xc71KeJKGHXrlMcIG1aKdr7WtqcVrutJbOv97KLGzA8kg89ZODNHgDy0HcJRh_pL1eLnIC6FzrdcXexx82_HdtPZ1c76z-QNKWe</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Park, J.‐E.</creator><creator>Oh, S.‐H.</creator><creator>Cha, Y.‐S.</creator><general>Blackwell</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201401</creationdate><title>Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice</title><author>Park, J.‐E. ; Oh, S.‐H. ; Cha, Y.‐S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-e4db2836b2494c13168d3d0b98342c20a7eb9abbddbd0021ac2d47d3f3b2ad373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>antiobesity</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gajami sik‐hae</topic><topic>high‐fat diet</topic><topic>Lactobacillus plantarum</topic><topic>Lactobacillus plantarum LG42</topic><topic>Microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, J.‐E.</creatorcontrib><creatorcontrib>Oh, S.‐H.</creatorcontrib><creatorcontrib>Cha, Y.‐S.</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, J.‐E.</au><au>Oh, S.‐H.</au><au>Cha, Y.‐S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>116</volume><issue>1</issue><spage>145</spage><epage>156</epage><pages>145-156</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Aims
This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik‐hae.
Methods and Results
Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high‐fat diet & DW), LGLAB (high‐fat diet & Lactobacillus plantarum LG42, 1 × 107 CFU per mouse), HGLAB (high‐fat diet & L. plantarum LG42, 1 × 109 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT‐I were significantly increased in GLAB groups, whereas the level of ACC, SREBP‐1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
Conclusion
These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high‐fat‐diet‐induced obese mice.
Significance and Impact of the Study
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24131682</pmid><doi>10.1111/jam.12354</doi><tpages>12</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Wiley Online Library Journals Frontfile Complete |
| subjects | antiobesity Biological and medical sciences Fundamental and applied biological sciences. Psychology gajami sik‐hae high‐fat diet Lactobacillus plantarum Lactobacillus plantarum LG42 Microbiology |
| title | Lactobacillus plantarum LG42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice |
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