Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process. e57324

G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte growth via novel nuclear localization. In the nucle...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3)
Hauptverfasser:	Gold, Jessica I, Martini, Jeffrey S, Hullmann, Jonathan, Gao, Erhe, Chuprun, J Kurt, Lee, Linda, Tilley, Douglas G, Rabinowitz, Joseph E, Bossuyt, Julie, Bers, Donald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium
Online-Zugang:	Volltext
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