Detection of cytoplasmic nucleophosmin expression by imaging flow cytometry

Mutations within the nucleophosmin NPM1 gene occur in approximately one‐third of cases of acute myeloid leukemia (AML). These mutations result in cytoplasmic accumulation of the mutant NPM protein. NPM1 mutations are currently detected by molecular methods. Using samples from 37 AML patients, we inv...

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Veröffentlicht in:	Cytometry. Part A 2012-10, Vol.81A (10), p.896-900
Hauptverfasser:	Grimwade, Lizz, Gudgin, Emma, Bloxham, David, Bottley, Graham, Vassiliou, George, Huntly, Brian, Scott, Mike A., Erber, Wendy N.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute leukemia Acute myeloid leukemia Adult Aged Aged, 80 and over Anthraquinones Antibodies Bone Marrow - metabolism Bone Marrow - pathology Cell Nucleus - genetics Cell Nucleus - metabolism Cytoplasm - genetics Cytoplasm - metabolism Female Flow Cytometry Gene Expression hematology Humans imaging flow cytometry Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - pathology Male Middle Aged Mutation Neoplasm, Residual - diagnosis Neoplasm, Residual - genetics Neoplasm, Residual - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism nucleophosmin Research Design Sensitivity and Specificity Staining and Labeling
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