Recent Advances in the Search for Novel 5‐Lipoxygenase Inhibitors

5‐Lipoxygenase (5‐LO) is an important enzyme of the arachidonic acid cascade and catalyses with the help of FLAP, the 5‐LO‐activating protein, the formation of bioactive leukotrienes (LTs). LTs are inflammatory mediators playing a pathophysiological role in different diseases such as asthma, allergi...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2014-01, Vol.114 (1), p.70-77
Hauptverfasser:	Steinhilber, Dieter, Hofmann, Bettina
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic rhinitis Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acid - metabolism Asthma Biological and medical sciences Computational Biology Drug Design Humans Leukotrienes - metabolism Lipoxygenase Inhibitors - pharmacology Medical research Medical sciences Pharmaceutical industry Pharmacology. Drug treatments Pyrroles - pharmacology Rhinitis, Allergic Rhinitis, Allergic, Perennial - drug therapy
Online-Zugang:	Volltext
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