In vitro/in vivo comparison of cefuroxime release from poly(ε-caprolactone)-calcium sulfate implants for osteomyelitis treatment

This study aimed to investigate the release of cefuroxime axetil (CF) and calcium from poly(ε‐caprolactone) (PCL)–calcium sulfate (CaS) implants (PCL:CaS 2:1–10% CF; PCL:CaS 2:1–20% CF; PCL:CaS 1:1–10% CF) for treating infectious bone diseases. Bioactivity, crystallinity and strength, and release pr...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2013-11, Vol.60 (6), p.603-616
Hauptverfasser:	Yaprakci, Volkan, Erdemli, Ozge, Kayabolen, Alisan, Tezcaner, Aysen, Bozkurt, Fatih, Keskin, Dilek
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological activity bone substitute calcium sulfate Calcium Sulfate - chemistry Cefuroxime - analogs & derivatives Cefuroxime - chemistry Cefuroxime - therapeutic use cefuroxime axetil Cell Line, Tumor controlled release Drug Carriers - chemistry Drug Carriers - toxicity Humans Mice osteomyelitis Osteomyelitis - drug therapy Osteomyelitis - pathology polycaprolactone Polyesters - chemistry Rabbits Temperature
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