High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592
Objective To determine the incidence of pulmonary tuberculosis (TB) in inmates, factors associated with TB, and the time to sputum smear and culture conversion during TB treatment. Methods Prospective cohort study. All prisoners with respiratory symptoms (RS) of any duration were evaluated. After pa...
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| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11) |
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| creator | Rueda, Zulma Vanessa Lopez, Lucelly Velez, Lazaro A Marin, Diana Giraldo, Margarita Rosa Pulido, Henry Orozco, Luis Carlos Montes, Fernando Arbelaez, Maria Patricia |
| description | Objective To determine the incidence of pulmonary tuberculosis (TB) in inmates, factors associated with TB, and the time to sputum smear and culture conversion during TB treatment. Methods Prospective cohort study. All prisoners with respiratory symptoms (RS) of any duration were evaluated. After participants signed consent forms, we collected three spontaneous sputum samples on consecutive days. We performed auramine-rhodamine staining, culturing with the thin-layer agar method, Lowestein-Jensen medium and MGIT, susceptibility testing for first-line drugs; and HIV testing. TB cases were followed, and the times to smear and culture conversion to negative were evaluated. Results Of 9,507 prisoners held in four prisons between April/30/2010 and April/30/2012, among them 4,463 were screened, 1,305 were evaluated for TB because of the lower RS of any duration, and 72 were diagnosed with TB. The annual incidence was 505 cases/100,000 prisoners. Among TB cases, the median age was 30 years, 25% had |
| doi_str_mv | 10.1371/journal.pone.0080592 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492639730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492639730</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_14926397303</originalsourceid><addsrcrecordid>eNqVzs1Kw0AUBeBBEKw_b-DiLl3YOMnYtHEn1VLBRSHdl-nkNpkyubfOj9Kn8VWNIu5dHTh8B44Q17nMcjXN7_acPGmXHZgwk3ImJ1VxIkZ5pYpxWUh1Js5D2Es5UbOyHInPpW07eCFjGySDwDtYpy16kxwHG27hlT-gRgo22ncbj99gnrxHivBkdUscojVQmw57BE0NrDw7phabwbmYPMKK_9aWYDEchPlg-q3VNHAbmEIGj0PZsY9Qx9QcHwB_rl-K0512Aa9-80LcLJ7X8-X44PktYYib3gaDzmlCTmGT31dFqaqpkuof9At_9WZD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1492639730</pqid></control><display><type>article</type><title>High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Rueda, Zulma Vanessa ; Lopez, Lucelly ; Velez, Lazaro A ; Marin, Diana ; Giraldo, Margarita Rosa ; Pulido, Henry ; Orozco, Luis Carlos ; Montes, Fernando ; Arbelaez, Maria Patricia</creator><creatorcontrib>Rueda, Zulma Vanessa ; Lopez, Lucelly ; Velez, Lazaro A ; Marin, Diana ; Giraldo, Margarita Rosa ; Pulido, Henry ; Orozco, Luis Carlos ; Montes, Fernando ; Arbelaez, Maria Patricia</creatorcontrib><description>Objective To determine the incidence of pulmonary tuberculosis (TB) in inmates, factors associated with TB, and the time to sputum smear and culture conversion during TB treatment. Methods Prospective cohort study. All prisoners with respiratory symptoms (RS) of any duration were evaluated. After participants signed consent forms, we collected three spontaneous sputum samples on consecutive days. We performed auramine-rhodamine staining, culturing with the thin-layer agar method, Lowestein-Jensen medium and MGIT, susceptibility testing for first-line drugs; and HIV testing. TB cases were followed, and the times to smear and culture conversion to negative were evaluated. Results Of 9,507 prisoners held in four prisons between April/30/2010 and April/30/2012, among them 4,463 were screened, 1,305 were evaluated for TB because of the lower RS of any duration, and 72 were diagnosed with TB. The annual incidence was 505 cases/100,000 prisoners. Among TB cases, the median age was 30 years, 25% had <15 days of cough, 12.5% had a history of prior TB, and 40.3% had prior contact with a TB case. TB-HIV coinfection was diagnosed in three cases. History of prior TB, contact with a TB case, and being underweight were risk factors associated with TB. Overweight was a protective factor. Almost a quarter of TB cases were detected only by culture; three cases were isoniazid resistant, and two resistant to streptomycin. The median times to culture conversion was 59 days, and smear conversion was 33. Conclusions The TB incidence in prisons is 20 times higher than in the general Colombian population. TB should be considered in inmates with lower RS of any duration. Our data demonstrate that patients receiving adequate anti-TB treatment remain infectious for prolonged periods. These findings suggest that current recommendations regarding isolation of prisoners with TB should be reconsidered, and suggest the need for mycobacterial cultures during follow-up.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0080592</identifier><language>eng</language><subject>Mycobacterium</subject><ispartof>PloS one, 2013-11, Vol.8 (11)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Rueda, Zulma Vanessa</creatorcontrib><creatorcontrib>Lopez, Lucelly</creatorcontrib><creatorcontrib>Velez, Lazaro A</creatorcontrib><creatorcontrib>Marin, Diana</creatorcontrib><creatorcontrib>Giraldo, Margarita Rosa</creatorcontrib><creatorcontrib>Pulido, Henry</creatorcontrib><creatorcontrib>Orozco, Luis Carlos</creatorcontrib><creatorcontrib>Montes, Fernando</creatorcontrib><creatorcontrib>Arbelaez, Maria Patricia</creatorcontrib><title>High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592</title><title>PloS one</title><description>Objective To determine the incidence of pulmonary tuberculosis (TB) in inmates, factors associated with TB, and the time to sputum smear and culture conversion during TB treatment. Methods Prospective cohort study. All prisoners with respiratory symptoms (RS) of any duration were evaluated. After participants signed consent forms, we collected three spontaneous sputum samples on consecutive days. We performed auramine-rhodamine staining, culturing with the thin-layer agar method, Lowestein-Jensen medium and MGIT, susceptibility testing for first-line drugs; and HIV testing. TB cases were followed, and the times to smear and culture conversion to negative were evaluated. Results Of 9,507 prisoners held in four prisons between April/30/2010 and April/30/2012, among them 4,463 were screened, 1,305 were evaluated for TB because of the lower RS of any duration, and 72 were diagnosed with TB. The annual incidence was 505 cases/100,000 prisoners. Among TB cases, the median age was 30 years, 25% had <15 days of cough, 12.5% had a history of prior TB, and 40.3% had prior contact with a TB case. TB-HIV coinfection was diagnosed in three cases. History of prior TB, contact with a TB case, and being underweight were risk factors associated with TB. Overweight was a protective factor. Almost a quarter of TB cases were detected only by culture; three cases were isoniazid resistant, and two resistant to streptomycin. The median times to culture conversion was 59 days, and smear conversion was 33. Conclusions The TB incidence in prisons is 20 times higher than in the general Colombian population. TB should be considered in inmates with lower RS of any duration. Our data demonstrate that patients receiving adequate anti-TB treatment remain infectious for prolonged periods. These findings suggest that current recommendations regarding isolation of prisoners with TB should be reconsidered, and suggest the need for mycobacterial cultures during follow-up.</description><subject>Mycobacterium</subject><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVzs1Kw0AUBeBBEKw_b-DiLl3YOMnYtHEn1VLBRSHdl-nkNpkyubfOj9Kn8VWNIu5dHTh8B44Q17nMcjXN7_acPGmXHZgwk3ImJ1VxIkZ5pYpxWUh1Js5D2Es5UbOyHInPpW07eCFjGySDwDtYpy16kxwHG27hlT-gRgo22ncbj99gnrxHivBkdUscojVQmw57BE0NrDw7phabwbmYPMKK_9aWYDEchPlg-q3VNHAbmEIGj0PZsY9Qx9QcHwB_rl-K0512Aa9-80LcLJ7X8-X44PktYYib3gaDzmlCTmGT31dFqaqpkuof9At_9WZD</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Rueda, Zulma Vanessa</creator><creator>Lopez, Lucelly</creator><creator>Velez, Lazaro A</creator><creator>Marin, Diana</creator><creator>Giraldo, Margarita Rosa</creator><creator>Pulido, Henry</creator><creator>Orozco, Luis Carlos</creator><creator>Montes, Fernando</creator><creator>Arbelaez, Maria Patricia</creator><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20131101</creationdate><title>High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592</title><author>Rueda, Zulma Vanessa ; Lopez, Lucelly ; Velez, Lazaro A ; Marin, Diana ; Giraldo, Margarita Rosa ; Pulido, Henry ; Orozco, Luis Carlos ; Montes, Fernando ; Arbelaez, Maria Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_14926397303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Mycobacterium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rueda, Zulma Vanessa</creatorcontrib><creatorcontrib>Lopez, Lucelly</creatorcontrib><creatorcontrib>Velez, Lazaro A</creatorcontrib><creatorcontrib>Marin, Diana</creatorcontrib><creatorcontrib>Giraldo, Margarita Rosa</creatorcontrib><creatorcontrib>Pulido, Henry</creatorcontrib><creatorcontrib>Orozco, Luis Carlos</creatorcontrib><creatorcontrib>Montes, Fernando</creatorcontrib><creatorcontrib>Arbelaez, Maria Patricia</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rueda, Zulma Vanessa</au><au>Lopez, Lucelly</au><au>Velez, Lazaro A</au><au>Marin, Diana</au><au>Giraldo, Margarita Rosa</au><au>Pulido, Henry</au><au>Orozco, Luis Carlos</au><au>Montes, Fernando</au><au>Arbelaez, Maria Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592</atitle><jtitle>PloS one</jtitle><date>2013-11-01</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><eissn>1932-6203</eissn><abstract>Objective To determine the incidence of pulmonary tuberculosis (TB) in inmates, factors associated with TB, and the time to sputum smear and culture conversion during TB treatment. Methods Prospective cohort study. All prisoners with respiratory symptoms (RS) of any duration were evaluated. After participants signed consent forms, we collected three spontaneous sputum samples on consecutive days. We performed auramine-rhodamine staining, culturing with the thin-layer agar method, Lowestein-Jensen medium and MGIT, susceptibility testing for first-line drugs; and HIV testing. TB cases were followed, and the times to smear and culture conversion to negative were evaluated. Results Of 9,507 prisoners held in four prisons between April/30/2010 and April/30/2012, among them 4,463 were screened, 1,305 were evaluated for TB because of the lower RS of any duration, and 72 were diagnosed with TB. The annual incidence was 505 cases/100,000 prisoners. Among TB cases, the median age was 30 years, 25% had <15 days of cough, 12.5% had a history of prior TB, and 40.3% had prior contact with a TB case. TB-HIV coinfection was diagnosed in three cases. History of prior TB, contact with a TB case, and being underweight were risk factors associated with TB. Overweight was a protective factor. Almost a quarter of TB cases were detected only by culture; three cases were isoniazid resistant, and two resistant to streptomycin. The median times to culture conversion was 59 days, and smear conversion was 33. Conclusions The TB incidence in prisons is 20 times higher than in the general Colombian population. TB should be considered in inmates with lower RS of any duration. Our data demonstrate that patients receiving adequate anti-TB treatment remain infectious for prolonged periods. These findings suggest that current recommendations regarding isolation of prisoners with TB should be reconsidered, and suggest the need for mycobacterial cultures during follow-up.</abstract><doi>10.1371/journal.pone.0080592</doi></addata></record> |
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| subjects | Mycobacterium |
| title | High Incidence of Tuberculosis, Low Sensitivity of Current Diagnostic Scheme and Prolonged Culture Positivity in Four Colombian Prisons. A Cohort Study: e80592 |
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