Stimulating ERK/PI3K/NFκB signaling pathways upon activation of mGluR2/3 restores OGD-induced impairment in glutamate clearance in astrocytes

We used the oxygen and glucose deprivation (OGD) method in cultured astrocytes as an in vitro ischemic model. We investigated whether activation of group‐II metabotropic glutamate receptors (mGluR2/3) can reverse OGD‐induced impairment in astrocytic glutamate/aspartate transporter (GLAST) expression...

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Veröffentlicht in:	The European journal of neuroscience 2014-01, Vol.39 (1), p.83-96
Hauptverfasser:	Lin, Chia-Ho, You, Jie-Ru, Wei, Kai-Che, Gean, Po-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals astrocyte GLAST Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cell Hypoxia Cells, Cultured Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Transporter 1 - metabolism extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Glucose - deficiency Glutamic Acid - metabolism MAP Kinase Signaling System mGluR2/3 agonists NF-kappa B - metabolism nuclear transcription factor-κΒ oxygen and glucose deprivation phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Vertebrates: nervous system and sense organs
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