No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis
ABSTRACT OBJECTIVE To investigate differences in region‐specific gray matter (GM) damage between adults with pediatric‐onset (PO) multiple sclerosis (MS) and adult‐onset (AO) MS. METHODS Twenty‐four relapsing‐remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) w...
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| Veröffentlicht in: | Journal of neuroimaging 2014-01, Vol.24 (1), p.63-67 |
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| container_title | Journal of neuroimaging |
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| creator | Donohue, Katelyn Cox, Jennifer L. Dwyer, Michael G. Aliotta, Rachel Corwin, Melanie Weinstock-Guttman, Bianca Ann Yeh, E. Zivadinov, Robert |
| description | ABSTRACT
OBJECTIVE
To investigate differences in region‐specific gray matter (GM) damage between adults with pediatric‐onset (PO) multiple sclerosis (MS) and adult‐onset (AO) MS.
METHODS
Twenty‐four relapsing‐remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age‐matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease‐duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three‐dimensional‐T1‐weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel‐based morphometry (Statistical Parametric Mapping 8).
RESULTS
There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
CONCLUSIONS
Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS. |
| doi_str_mv | 10.1111/j.1552-6569.2012.00775.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492638722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3177920251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4675-f9dc9444e78c983b15347d2f24367fb650d23c220e5496bfedbb25081ca3c6c3</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhSMEoqXwF5AlNmwS_HYisRkKTEHzQG0FS8txboqHTBJsR53593iYMgtW9cZHut85V_bJMkRwQdJ5tymIEDSXQlYFxYQWGCslit2T7Pw0eJo0FiSntORn2YsQNhhTwil7np1RxojCtDrPptWAruHODb3p0NybPVqaGMGjWfTD-HOPPrq2BQ-9hYBqiPcAPfoGjTPRO5sj0zdo1kxdzNd9gJiyOjMG19_l17B1MSaFlmnsxg7Qje3AD8GFl9mz1nQBXj3cF9nt50-3l1f5Yj3_cjlb5JZLJfK2amzFOQdV2qpkNRGMq4a2lDOp2loK3FBmKcUgeCXrFpq6pgKXxBpmpWUX2dtj7OiH3xOEqLcuWOg608MwBU14RSUrFaWPQbEiTNIyoW_-QzfD5NP_HSglWYWlxIkqj5RNLw4eWj16tzV-rwnWhxL1Rh-60oeu9KFE_bdEvUvW1w8LpnoLzcn4r7UEvD8C966D_aOD9df1Kolkz492FyLsTnbjf2mpWCJ_rOb6-83yA5Nioa_YH7kOuQ0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1476390660</pqid></control><display><type>article</type><title>No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Donohue, Katelyn ; Cox, Jennifer L. ; Dwyer, Michael G. ; Aliotta, Rachel ; Corwin, Melanie ; Weinstock-Guttman, Bianca ; Ann Yeh, E. ; Zivadinov, Robert</creator><creatorcontrib>Donohue, Katelyn ; Cox, Jennifer L. ; Dwyer, Michael G. ; Aliotta, Rachel ; Corwin, Melanie ; Weinstock-Guttman, Bianca ; Ann Yeh, E. ; Zivadinov, Robert</creatorcontrib><description>ABSTRACT
OBJECTIVE
To investigate differences in region‐specific gray matter (GM) damage between adults with pediatric‐onset (PO) multiple sclerosis (MS) and adult‐onset (AO) MS.
METHODS
Twenty‐four relapsing‐remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age‐matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease‐duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three‐dimensional‐T1‐weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel‐based morphometry (Statistical Parametric Mapping 8).
RESULTS
There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
CONCLUSIONS
Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS.</description><identifier>ISSN: 1051-2284</identifier><identifier>EISSN: 1552-6569</identifier><identifier>DOI: 10.1111/j.1552-6569.2012.00775.x</identifier><identifier>PMID: 23317029</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; adult-onset ; Age ; Aging - pathology ; Atrophy - pathology ; Brain - pathology ; Female ; Gray Matter - pathology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis, Relapsing-Remitting - pathology ; Neuroimaging ; pediatric-onset ; Pediatrics ; Recurrence ; regional atrophy ; Remission, Spontaneous ; Reproducibility of Results ; Sensitivity and Specificity ; voxel-based morphometry ; Young Adult</subject><ispartof>Journal of neuroimaging, 2014-01, Vol.24 (1), p.63-67</ispartof><rights>Copyright © 2013 by the American Society of Neuroimaging</rights><rights>Copyright © 2013 by the American Society of Neuroimaging.</rights><rights>Copyright © 2014 American Society of Neuroimaging</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4675-f9dc9444e78c983b15347d2f24367fb650d23c220e5496bfedbb25081ca3c6c3</citedby><cites>FETCH-LOGICAL-c4675-f9dc9444e78c983b15347d2f24367fb650d23c220e5496bfedbb25081ca3c6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1552-6569.2012.00775.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1552-6569.2012.00775.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23317029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donohue, Katelyn</creatorcontrib><creatorcontrib>Cox, Jennifer L.</creatorcontrib><creatorcontrib>Dwyer, Michael G.</creatorcontrib><creatorcontrib>Aliotta, Rachel</creatorcontrib><creatorcontrib>Corwin, Melanie</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Ann Yeh, E.</creatorcontrib><creatorcontrib>Zivadinov, Robert</creatorcontrib><title>No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis</title><title>Journal of neuroimaging</title><addtitle>Journal of Neuroimaging</addtitle><description>ABSTRACT
OBJECTIVE
To investigate differences in region‐specific gray matter (GM) damage between adults with pediatric‐onset (PO) multiple sclerosis (MS) and adult‐onset (AO) MS.
METHODS
Twenty‐four relapsing‐remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age‐matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease‐duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three‐dimensional‐T1‐weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel‐based morphometry (Statistical Parametric Mapping 8).
RESULTS
There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
CONCLUSIONS
Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS.</description><subject>Adult</subject><subject>adult-onset</subject><subject>Age</subject><subject>Aging - pathology</subject><subject>Atrophy - pathology</subject><subject>Brain - pathology</subject><subject>Female</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - pathology</subject><subject>Neuroimaging</subject><subject>pediatric-onset</subject><subject>Pediatrics</subject><subject>Recurrence</subject><subject>regional atrophy</subject><subject>Remission, Spontaneous</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>voxel-based morphometry</subject><subject>Young Adult</subject><issn>1051-2284</issn><issn>1552-6569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEoqXwF5AlNmwS_HYisRkKTEHzQG0FS8txboqHTBJsR53593iYMgtW9cZHut85V_bJMkRwQdJ5tymIEDSXQlYFxYQWGCslit2T7Pw0eJo0FiSntORn2YsQNhhTwil7np1RxojCtDrPptWAruHODb3p0NybPVqaGMGjWfTD-HOPPrq2BQ-9hYBqiPcAPfoGjTPRO5sj0zdo1kxdzNd9gJiyOjMG19_l17B1MSaFlmnsxg7Qje3AD8GFl9mz1nQBXj3cF9nt50-3l1f5Yj3_cjlb5JZLJfK2amzFOQdV2qpkNRGMq4a2lDOp2loK3FBmKcUgeCXrFpq6pgKXxBpmpWUX2dtj7OiH3xOEqLcuWOg608MwBU14RSUrFaWPQbEiTNIyoW_-QzfD5NP_HSglWYWlxIkqj5RNLw4eWj16tzV-rwnWhxL1Rh-60oeu9KFE_bdEvUvW1w8LpnoLzcn4r7UEvD8C966D_aOD9df1Kolkz492FyLsTnbjf2mpWCJ_rOb6-83yA5Nioa_YH7kOuQ0</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Donohue, Katelyn</creator><creator>Cox, Jennifer L.</creator><creator>Dwyer, Michael G.</creator><creator>Aliotta, Rachel</creator><creator>Corwin, Melanie</creator><creator>Weinstock-Guttman, Bianca</creator><creator>Ann Yeh, E.</creator><creator>Zivadinov, Robert</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis</title><author>Donohue, Katelyn ; Cox, Jennifer L. ; Dwyer, Michael G. ; Aliotta, Rachel ; Corwin, Melanie ; Weinstock-Guttman, Bianca ; Ann Yeh, E. ; Zivadinov, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4675-f9dc9444e78c983b15347d2f24367fb650d23c220e5496bfedbb25081ca3c6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>adult-onset</topic><topic>Age</topic><topic>Aging - pathology</topic><topic>Atrophy - pathology</topic><topic>Brain - pathology</topic><topic>Female</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - pathology</topic><topic>Neuroimaging</topic><topic>pediatric-onset</topic><topic>Pediatrics</topic><topic>Recurrence</topic><topic>regional atrophy</topic><topic>Remission, Spontaneous</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>voxel-based morphometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donohue, Katelyn</creatorcontrib><creatorcontrib>Cox, Jennifer L.</creatorcontrib><creatorcontrib>Dwyer, Michael G.</creatorcontrib><creatorcontrib>Aliotta, Rachel</creatorcontrib><creatorcontrib>Corwin, Melanie</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Ann Yeh, E.</creatorcontrib><creatorcontrib>Zivadinov, Robert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donohue, Katelyn</au><au>Cox, Jennifer L.</au><au>Dwyer, Michael G.</au><au>Aliotta, Rachel</au><au>Corwin, Melanie</au><au>Weinstock-Guttman, Bianca</au><au>Ann Yeh, E.</au><au>Zivadinov, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis</atitle><jtitle>Journal of neuroimaging</jtitle><addtitle>Journal of Neuroimaging</addtitle><date>2014-01</date><risdate>2014</risdate><volume>24</volume><issue>1</issue><spage>63</spage><epage>67</epage><pages>63-67</pages><issn>1051-2284</issn><eissn>1552-6569</eissn><abstract>ABSTRACT
OBJECTIVE
To investigate differences in region‐specific gray matter (GM) damage between adults with pediatric‐onset (PO) multiple sclerosis (MS) and adult‐onset (AO) MS.
METHODS
Twenty‐four relapsing‐remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age‐matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease‐duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three‐dimensional‐T1‐weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel‐based morphometry (Statistical Parametric Mapping 8).
RESULTS
There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
CONCLUSIONS
Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23317029</pmid><doi>10.1111/j.1552-6569.2012.00775.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1051-2284 |
| ispartof | Journal of neuroimaging, 2014-01, Vol.24 (1), p.63-67 |
| issn | 1051-2284 1552-6569 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult adult-onset Age Aging - pathology Atrophy - pathology Brain - pathology Female Gray Matter - pathology Humans Magnetic Resonance Imaging - methods Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - pathology Neuroimaging pediatric-onset Pediatrics Recurrence regional atrophy Remission, Spontaneous Reproducibility of Results Sensitivity and Specificity voxel-based morphometry Young Adult |
| title | No Regional Gray Matter Atrophy Differences between Pediatric- and Adult-Onset Relapsing-Remitting Multiple Sclerosis |
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